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Analysis of Circulating CD34-positive Cells in Alzheimer' Disease  

Lee, Soon-Tae (Department of Neurology, Seoul National University Hospital)
Chu, Kon (Department of Neurology, Seoul National University Hospital)
Jung, Keun-Hwa (Department of Neurology, Seoul National University Hospital)
Sim, Ji-Young (Department of Neurology, Seoul National University Hospital)
Oh, Min-Jeong (Department of Neurology, Seoul National University Hospital)
Park, Myoung-Hee (Department of Laboratory Medicine, Seoul National University Hospital)
Kim, Man-Ho (Department of Neurology, Seoul National University Hospital)
Publication Information
Dementia and Neurocognitive Disorders / v.9, no.3, 2010 , pp. 88-92 More about this Journal
Abstract
Background: Circulating CD34-positive cells constitute the endothelial progenitor cell population, differentiate into endothelial cells, and contribute to mammalian brain regeneration. Given the vascular endothelial pathogenesis of Alzheimer' disease (AD), we investigated the levels of CD34+ cells in AD patients. Methods: Sixty-six consecutive patients with probable AD (clinical dementia rating scale 1) and 22 age-matched control subjects were enrolled. CD34+ cells were counted in their peripheral blood samples and analyzed in comparison with their clinical characteristics. Results: The AD patients had significantly lower numbers of CD34-positive cells than control subjects. However, the number of CD34-positive cells was not correlated with clinical characteristics of AD patients, including Mini Mental State Examination (MMSE) score, Framingham risk score, body-mass index, and changes in MMSE during 3 months. Conclusions: AD patients have diminished circulating CD34-positive cells, suggesting the reduced regenerative support from the peripheral blood in AD patients.
Keywords
Alzheimer' disease; CD34; Endothelial progenitor cells; Biomarker; Mini-mental state examination;
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1 Benarroch EE. Neurovascular unit dysfunction: a vascular component of Alzheimer disease? Neurology 2007; 68: 1730-2   DOI   ScienceOn
2 Zlokovic BV. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci 2005; 28: 202-8   DOI   ScienceOn
3 Weller RO, Subash M, Preston SD, Mazanti I, Carare RO. Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. Brain Pathol 2008; 18: 253-66
4 Lee ST, Jung KH, Lee YS. Decreased vasomotor reactivity in Alzheimer's disease. J Clin Neurol 2007; 3: 18-23   DOI   ScienceOn
5 Breteler MM. Vascular risk factors for Alzheimer's disease: an epidemiologic perspective. Neurobiol Aging 2000; 21: 153-60
6 Hristov M, Erl W, Weber PC. Endothelial progenitor cells: mobilization, differentiation, and homing. Arterioscler Thromb Vasc Biol 2003; 23: 185-9
7 ahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964-7   DOI   ScienceOn
8 Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 2000; 290: 1779-82   DOI   ScienceOn
9 Cogle CR, Yachnis AT, Laywell ED, Zander DS, Wingard JR, Steindler DA, et al. Bone marrow transdifferentiation in brain after transplantation: a retrospective study. Lancet 2004; 363: 1432-7   DOI   ScienceOn
10 Maler JM, Spitzer P, Lewczuk P, Kornhuber J, Herrmann M, Wiltfang J. Decreased circulating cd34(+) stem cells in early alzheimer's disease: Evidence for a deficient hematopoietic brain support? Mol Psychiatry 2006; 11: 1113-5   DOI   ScienceOn
11 Taguchi A, Matsuyama T, Nakagomi T, Shimizu Y, Fukunaga R, Tatsumi Y, et al. Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment. J Cereb Blood Flow Metab 2008; 28: 445-9   DOI   ScienceOn
12 Stellos K, Panagiota V, Sachsenmaier S, Trunk T, Straten G, Leyhe T, et al. Increased circulating progenitor cells in Alzheimer's disease patients with moderate to severe dementia: evidence for vascular repair and tissue regeneration? J Alzheimers Dis 2010; 19: 591-600   DOI
13 Lee ST, Chu K, Jung KH, Park HK, Kim DH, Bahn JJ, et al. Reduced circulating angiogenic cells in Alzheimer disease Neurology 2009; 72: 1858-63   DOI   ScienceOn
14 McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDSADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-44   DOI
15 Schmidt-Lucke C, Rossig L, Fichtlscherer S, Vasa M, Britten M, Kamper U, et al. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation 2005; 111: 2981-7   DOI   ScienceOn
16 Dimmeler S, Aicher A, Vasa M, Mildner-Rihm C, Adler K, Tiemann M, et al. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. J Clin Invest 2001; 108: 391-7   DOI   ScienceOn
17 Kang HJ, Kim HS, Zhang SY, Park KW, Cho HJ, Koo BK, et al. Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. Lancet 2004; 363: 751-6   DOI   ScienceOn
18 Taguchi A, Matsuyama T, Moriwaki H, Hayashi T, Hayashida K, Nagatsuka K, et al. Circulating CD34-positive cells provide an index of cerebrovascular function. Circulation 2004; 109: 2972-5   DOI   ScienceOn
19 Thum T, Hoeber S, Froese S, Klink I, Stichtenoth DO, Galuppo P, et al. Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1. Circ Res 2007; 100: 434-43   DOI   ScienceOn
20 Song IU, Kim JS, Kim YI, Eah KY, Lee KS. Clinical significance of silent cerebral infarctions in patients with Alzheimer disease. Cogn Behav Neurol 2007; 20: 93-8   DOI   ScienceOn