Browse > Article

Effect of deproteinized bovine bone mineral soaked in inorganic polyphosphate on bone regeneration  

Na, Seong-Yoon (Department of Periodontology and Institute of Oral Biology, School of Dentistry, Kyung Hee University)
Kwon, Young-Hyuk (Department of Periodontology and Institute of Oral Biology, School of Dentistry, Kyung Hee University)
Park, Joon-Bong (Department of Periodontology and Institute of Oral Biology, School of Dentistry, Kyung Hee University)
Herr, Yeek (Department of Periodontology and Institute of Oral Biology, School of Dentistry, Kyung Hee University)
Chung, Jong-Hyuk (Department of Periodontology and Institute of Oral Biology, School of Dentistry, Kyung Hee University)
Publication Information
Journal of Periodontal and Implant Science / v.37, no.1, 2007 , pp. 77-89 More about this Journal
Abstract
This study was performed to evaluate the effect of deproteinized bovine bone mineral soaked in inorganic polyphosphate on bone regeneration in the calvaria of rabbit in the procedure of guided bone regeneration with titanium reinforced expanded polytetrafluoroethylene(TR-ePTFE) membrane. The rabbits were divided into four groups. Control group used TR-ePTFE membrane filled with de-proteinized bovine bone mineral, experimental group I used TR-ePTFE membrane and deproteinized bovine bone mineral soaked in 4% inorganic polyphosphate, experimental group II and III used TR-ePTFE membrane and deproteinized bovine bone mineral soaked in 8% or 16% inorganic poly-phosphate respectively. After decortication in the calvaria, GBR procedure was performed on 8 rabbits with only TR-ePTFE membrane or titanium reinforced ePTFE membrane filled with deproteinized bovine bone mineral soaked in inorganic polyphosphate. The animals were sacrificed at 4 weeks, and 8 weeks af-ter the surgery. Non-decalcified specimens were processed for histologic analysis, and new bone for-mation was assessed by histomorphometric as well as statical analysis. 1. Both control group and experirrental group dermnstrated increasing of new bone formation until 8weeks. 2. At 8 weeks, experimental group I and group II showed the significant difference compared to control group in new bone formation. Especially experimental group II showed the most in-creasing of new bone formation. 3. The higher concentration of inorganic polyphosphate filled, the more volume of bone formation pro-moted, but experimental group III did not reveal significant difference compared to contol group. 4. Deproteinized bovine bone mineral did not resorbed at all until 8 weeks. These results suggest that inorganic polyphosphate has a promoting effect on bone regeneration. possibly by enhancing osteoconductivity of the carrier and by increasing osteoinductivity of the defected alveolar bone tissue, but not as we respect.
Keywords
Inorganic polyphosphate; Bone regeneration; Osteoconductivity; Osteoinductivity;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Linkhart TA, Mohan S, Baylink DJ. Growth factors for bone growth and repair: IGF, TGF-$\beta$ and BMF. Bone 1996;19:1-12   DOI   ScienceOn
2 Bostrom MPG, Asnis P, Transforming growth factor beta in fracture repair. Clin Orthop Rel Res 1998; 355:124-131
3 Dahlin C, Linde A, Gottlow J, Nyman S. Healing of bone defects by guided tissue regeneration. Plastic Reconst Sur 1988;81:672-677   DOI   ScienceOn
4 Sandberg E, Dahlin C, Linde A. Bone regeneration by the osteopromotive technique using bioabsorbable membranes. An experimental study in rats. Int J Oral Maxillofac Surg 1993;51:1106-1114   DOI   ScienceOn
5 Dahlin C, Lekholm U, Becker W, et al, Treatment of fenestration and dehiscence bone defects around oral implants using the guided tissue regeneration technique: A prospective multicenter study. Int J Oral Maxillofac Imp 1995; 10: 312-318
6 Hammerle CHF, Olah AJ, Schmid J, et al. The biological effect of deproteinized bovine bone on bone neoformation on the rabbit skull. Clin Oral Impl Res 1997;8:198-207   DOI   ScienceOn
7 Donos N, Kostopoulos L, Karring T. Augmentation of the mandible with Gill and onlay cortical bone grafting. An experimental study in the rat. Clin Oral Impl Res 2002; 13:175-184   DOI   ScienceOn
8 Von Arx T, Cochran DL, Hermann JS, Schenk RK, Buser D. Lateral ridge augmentation using different bone fillers and barrier membrane application. A histologic and histomorphometric pilot study in the mandible. Clin Oral Impl Res 2001;12:260-269   DOI
9 Jovanovic SA, Schenk RK, Orsini M, Kenney Eb. Supracrestal bone formation around dental implants: An experimental dog study. Int J Oral .Maxillofac Implants 1995;10:23-31
10 Jovanovic SA, Nevins M. Bone formation utilizing titanium-reinforced barrier membranes. Int J Periodont Rest Dent 1995;15:57-69
11 Donos N, Kostopoulos L, Karring T. Augmentation of the mandible with GTR and onlay cortical bone grafting. An experimental study in the rat. Clin Oral Impl Res 2002;13:175-184   DOI   ScienceOn
12 Nevins M, Mellonig JT. Enhancement of the damaged edentulous ridge to receive dental implants: A combination of allograft and the GORE-TEX membrane. Int J Periodont Rest Dent 1992;12:97-111
13 Jovanovic SA, Spiekermann H, Richter EJ. Bone regeneration around titanium implants in dehiscenced defect sites: A clinical study. Int J Oral Maxillofac Implants 1992;7: 233-245   PUBMED
14 Slott C, Lundgren D. Augmentation of calvarial tissue using non-permeable silicone domes and bovine bone mineral. An experimental study in the rat. Clin Oral ImplRes 1999;10:468-476   DOI   ScienceOn
15 Malchiodi L, Scarano A, Quaranta M, Piattelli A. Rigid fixation by means of titanium mesh in edentulous ridge expansion for horizontal ridge augmentation in the maxilla. Int J Oral Maxillofac Implants 1998;13:701-705
16 Bostrom MFG, Asnis P. Transforming growth factor beta in fracture repair. Clin Orthop Rel Res 1998;355:124-131
17 Becker W, Becker B, Handelsman M, Ochsenbein C, Albrektsson T. Guided tissue regeneration for implant placed into extraction sockets: A study in dogs. J Periodontol 1991;62:703-709   DOI   PUBMED
18 Reddi AH, Weintroub S, Muthukumaran N. Biologic principles of bone induction. Orthop Clin North Am 1987;18:207-212   PUBMED
19 Burchardt H. The biology of bone graft repair. Clin Orthop Rel Res 1983;174:28-42
20 Donos N, Kostopoulos L, Karring T. Augmentation of the rat jaw with autogenic corti co-cancellous bone grafts and guided tissue regeneration. Clin Oral Impl Res 2002; 13:192-202   DOI   ScienceOn
21 Donos N, Kostopoulos L, Karring T. Alveolar ridge augmentation by combining autogenous mandibular bone grafts and non-resorbable membranes. An experimental study in the rat. Clin Oral Impl Res 2002;13:185-191   DOI   ScienceOn
22 Jovanovic SA, Nevins M. Bone formation utilizing titanium-reinforced barrier membranes, Int J Periodont Rest Dent 1995;15:57-69
23 Urist MR. Bone Formation by autoinduction. Science 1965:150:893-899   DOI   ScienceOn
24 Linkhart TA, Mohan S, Baylink DJ. Growth factors for bone growth and repair: IGF, TGF-$\beta$ and BMF. Bone 1996:19:1-12   DOI   ScienceOn
25 Buser D, Bragger D, Land NP, Nyman S. Regeneration and enlargement of jaw bone using guided tissue regeneration. Clin Oral Impl Res 1990;1:22-32   DOI   ScienceOn
26 Lang NP, Hammerle CHF, Bragger D, Lehmann B, Nyman SR, Guided tissue regeneration in jaw bone defects prior to implant placement, Clin Oral Impl Res 1994;5:92-97   DOI   ScienceOn
27 Von Arx T, Cochran DL, Hermann JS, Schenk RK, Buser D. Lateral ridge augmentation using different bone fillers and barrier membrane application. A histologic and histomorphometric pilot study in the mandible. Clin Oral Impl Res 2001;12:260-269   DOI
28 Leckholm U, Becker W, Dahlin C, et al, The role of early versus late removal of Gemembrane on bone formation at oral implants placed into immediate extraction sockets. An experimental study in dogs. Clin Oral Impl Res 1993;4:121-129   DOI   ScienceOn
29 Donos N, Kostopoulos L, Karring T. Augmentation of the rat jaw with autogenic cortico-cancellous bone grafts and guided tissue regeneration. Clin Oral Impl Res 2002; 13:192-202   DOI   ScienceOn
30 Simon M, Trisi P, Piattellli A. Vertical ridge augmentation using a membrane technique associated with osseointegrated implants. Int J Periodont Rest Dent 1994;14:496-511
31 Becker W, Schenk R, Higuchi K, Lekholm U, Becker BE. Variations in bone regeneration adjacent to implants augmented with barrier membranes alone or with demineralized freeze -dried bone or autologous grafts: A study in dogs. Int J Oral Maxillofac Imp 1995;10: 143-154
32 Kostopoulos L, Karring T. Augmentation of the rat mandible using guided tissue regeneration. Clin Oral Impl Res 1994;5:75-82   DOI   ScienceOn
33 Ilizarov GA, The tension-stress effect on the genesis and growth of tissues: Part I. The influence of stability of fixation and soft tissue preservation. Clin Orthop 1989;238:249-281
34 Ilizarov GA, The tension-stress effect on the genesis and growth of tissues: Part II. The influence of rate and frequency of distraction. Clin Orthop 1989;239:263-285
35 Piattelli A, Scarano M, Corigliano Piattelli M, Comparison of bone regeneration with the use of mineralized and demineralized freeze-dried bone allografts: A histologic and histochemical study in man, Biomaterials 1996;17:1127 -1131   DOI   ScienceOn
36 Dahlin C, Linde A, Gottlow J, Nyman S. Healing of bone defects by guided tissue regeneration. Plastic Reconst Sur 1988;81: 672-677   DOI   ScienceOn
37 Bragger D, Hammerle CHF, Lang NP. Immediate transmucosal implants using the principle of guided tissue regeneration: A cross-sectional study comparing the clinical outcome 1 year after immediate to standard implant placement. Clin Oral Impl Res 1997;7: 268-276   DOI   ScienceOn
38 Nevins M, Mellonig JT. Enhancement of the damaged edentulous ridge to receive dental implants: A combination of allograft and the GORE-TEX membrane. Int J Periodont Rest Dent 1992;12:97-111
39 Nyman S, Lindhe J, Karring T. New attachment in the human periodontium by guided tissue regeneration. J Clin Periodontol 1982;9:290-296   DOI
40 Nevins M, Mellonig JT, Clem DSC III, Reiser GM, Buser DA, Implants in regenerated bone: long-term survival, Int J Periodont Rest Dent 1998;18:35-45