Browse > Article

The effect of calcium metaphosphate bone graft materials on bone regeneration  

Chae, Han-seung (Department of Periodontology, Graduate School, Seoul National University)
Lee, Yong-Moo (Department of Periodontology, Graduate School, Seoul National University)
Yang, Seung-Min (Department of Periodontology, Graduate School, Seoul National University, Department of Dentistry, College of Medicine, Sungkyunkwan University)
Chun, Sung-Soo (School of Material Science, College of Engineering, Youngnam University)
Kim, Suk-Young (School of Material Science, College of Engineering, Youngnam University)
Ku, Young (Department of Periodontology, Graduate School, Seoul National University)
Choung, Chong-Pyoung (Department of Periodontology, Graduate School, Seoul National University)
Han, Soo-Boo (Department of Periodontology, Graduate School, Seoul National University)
Choi, Sang-Mook (Department of Periodontology, Graduate School, Seoul National University)
Rhyu, In-Chul (Department of Periodontology, Graduate School, Seoul National University)
Publication Information
Journal of Periodontal and Implant Science / v.33, no.1, 2003 , pp. 13-26 More about this Journal
Abstract
Periodontal regeneration therapy with bone-substituting materials has gained favorable clinical efficacy by enhancing osseous regeneration in periodontal bony defect. As bone-substituting materials, bone powder, calcium phosphate ceramic, modified forms of hydroxyapatite, and hard tissue replacement polymer have demonstrated their periodontal bony regenerative potency. Bone-substituting materials should fulfill several requirements such as biocompatibility, osteogenecity, malleability, biodegradability. The purpose of this study was to investigate biocompatibility, osteo-conduction capacity and biodegradability of $Na_2O$, $K_2O$ added calcium metaphosphate(CMP). Beta CMP was obtained by thermal treatment of anhydrous $Ca_2(H_2PO_4)_2$. $Na_2O$ and $K_2O$ were added to CMP. The change of weight of pure CMP, $Na_2O$-CMP, and $K_2O$-CMP in Tris-buffer solution and simulated body fluid for 30 days was measured. Twenty four Newzealand white rabbits were used in negative control, positive control(Bio-Oss), pure CMP group, 5% $Na_2$-CMP group, 10% $Na_2O$-CMP goup, and 5% $K_2O$-CMP group. In each group, graft materials were placed in right and left parietal bone defects(diameter 10mm) of rabbit. The animals were sacrificed at 3 months and 6 months after implantation of the graft materials. Degree of biodegradability of $K_2O$ or $Na_2O$ added CMP was greater than that of pure CMP in experimental condition. All experimental sites were healed with no clinical evidence of inflammatory response to all CMP implants. Histologic observations revealed that all CMP grafts were very biocompatible and osseous conductive, and that in $K_2O$-CMP or $Na_2O$-CMP implanted sites, there was biodegradable pattern, and that in site of new bone formation, there was no significant difference between all CMP group and DPBB(Bio-Oss) group. From this result, it was suggested that all experimental CMP group graft materials were able to use as an available bone substitution.
Keywords
bone substitution$K_2O$-CMP$Na_2O$-CMP; biocompatibility; osseous-conduction;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Zamet JS, Dabar UR, Griffiths GS, Bulman JS, Bragger U, Burgin W, Newman HN: Particulate bioglass as a grafting material in treatment of periodontal intrabony defects. J Clin Periodontol 1997;24:410-418   DOI   ScienceOn
2 Louise F, Borghetti A: Clinical evaluation of natural coral implantation in osseous periodontal defects. Results after one year. J Parodontol 1991;10:69-76
3 Yukna RA: Synthetic bone grafts in periodontics. Periodontol 2000 1993;1:92-99   DOI   ScienceOn
4 Atala A, Vacanti JP, Peter CA, Mandel JP, Retik AB, Freeman MR: Formation of urothelial structures in vivo from dissociated cells attached to biodegradable polymer scaffolds in vitro. J Urol 1992;148:658-662   DOI
5 Moskow BS, Lubarr A. Histologic assessment of human periodontal defect after durapatite ceramic implant. J Periodntol 1983;54:455-462   DOI
6 Rabalais ML, Yukna RA, Mayer ET. Evaluation of durapatite ceramic as an alloplastic implant in periodontal osseous defects. I. Initial six-month results. J Periodontol 1981;52:680-689   DOI
7 Jarcho M. Biomaterial aspects of calcium phosphates. Dent Clinics N Am 1986;30:25-47   PUBMED
8 Nery EB, Eslami A, van Swol RL. Biphasic calcium phosphate ceramic combined with fibrillar collagen with and without citric acid conditioning in the treatment of periodontal osseous defects. J Periodontol 1990;61:166-172   DOI
9 Nery EB, Lee KK, Czajkowski S, Dooner JJ, Duggan M, Ellinger RF, Henken JM, Hines R, Miller M, Olson JW. A veterans administration cooperative study of biphasic calcium phosphate ceramic in periodonral osseous defects. J Periodontol 1990;61:737-744   DOI
10 White RA. Replamineform: A new process for preparing porous ceramic, metal, and polymer prosthetic materials. Science 1972;176:922-924   DOI   PUBMED   ScienceOn
11 Shaffer CD, App GR. The use of plaster of Paris in treating intrabony periodontal defects on humans. J Periodontol 1971;42:685-690   DOI
12 Puelacher WC, Vacnti JP, Ferraro NF, Schloo B, Vacnti CA: Femoral shaft reconstruction using tissue-engineered growth of bone. Int J Maxillofac Surg 1996;25:223-228   DOI   ScienceOn
13 Froum SJ, Kushner L, Scopp IW, Stahl SS. Human clinical and histologic responses to durapatite implants in intraosseous lesions. Case reports. J Periodontol 1982;53:719-725   DOI
14 Nery EB, LeGeros RZ, Lynch KL, Lee K. Tissue responses to biphasic calcium phosphate ceramic with different ratios of HA/BTCP in periodontal osseous defects. J Periodontol 1992;63:729-735   DOI
15 Mclntosh AO, Jablonski WL: X-ray powder patterns of the calcium phosphate, Analytical Chemistry 1956;28:1424-1427
16 Frame JW, Browne RM, Brady CL. Hydroxyapatite as a bone substitute in the jaws. Biomaterials 1981;2:19-22   DOI   ScienceOn
17 Froum SJ, Kushner L, Scopp W, Stahl SS: Human clinical and histologic response to durapatite implants in intraosseous lesions. J Periodontol 1982;53:719-725   DOI
18 Garret S. Periodontal regeneration around natural teeth. Ann Periodontol 1996;1:621-666   DOI   ScienceOn
19 이용무, 김석영, 신승윤, 구영, 류인철, 정종평: 생분해성 다공질 Calcium Metaphosphate 블록의 조직적합성에 관한 연구. 대한치주과학회지, 1998;28:559-567   과학기술학회마을
20 Baksh D, Davies JE, Kim S: Three-dimensional matrices of calcium polyphosphate support bone growth in vitro and in vivo. J Mat Sci: Mater Med 1998;9:743-748   DOI   ScienceOn
21 Kwan JY, Mefert RM, Carr RF, Weir JC. Clinical and histologic evaluations of HTR alloplastic grafting material: Case reports. Int J Periodontics Restorative Dent 1990;10:281-287
22 Vacanti CA, Kim W, Upton J, Vancanti MP, Mooney D, Schloo B, Vacanti JP: Tissue engineered growth of bone and cartilage. Transplant Proc 1993;25:1019-1021   PUBMED
23 YM Lee, YJ Seol, YT Lim, S Kim, SB Han, IC Rhyu, SH Baek, SJ Heo, JY Choi, PR Klokkevold, and CP Chung: Tissue engineered growth of bone by marrow cell transplantation using porous calcium metaphosphate matrices. J Biomed Mater Res 2001; 54: 216-223   DOI   ScienceOn
24 White EW, Shors EC. Biomaterial aspects of Interpore-200 porous hydroxyapatite. Dent Clin N Am 1986;30:49-65
25 Vacanti CA, Vacanti JP: Bone and cartilage reconstruction with tissue engineering approaches. Otolaringol Clin North Am 1994;27:263-276
26 Han T, Carranza FA Jr, Kennedy EB. Calcium phosphate in dentistry: A review of literature. J West Soc Periodontol Periodontal Abstr 1984;10:88-108
27 Levin MP, Getter L, Cutright DE, Bhaskar SN. Biodegradable ceramics in periodontal defects. Oral Surg Oral Med Oral Pathol 1994;38:344-351
28 Baldock WT, Hutchens LH, McFall WT, Simpson DM: An evaluation of tricalcium phosphate implants in human periodontal osseous defects of two patients. J Periodontol 1985;56:1-7
29 Ishaug SL, Crane GM, Miller MJ, Yasko AW, Yaszemski MJ, Mikos AG: Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds. J Biomed Mater Res 1997;36:17-28   DOI   ScienceOn
30 Nakahara H, Goldberg VM, Caplan AI: Culturedexpanded human periosteal-derived cells exhibited osteochondral potential in vivo. J Orthop Res 1991;9;465-476   DOI   PUBMED
31 Sugaya A, Minabe M, Hori T, Tatsmi J, Watanabe Y, Ikeda K, Numabe Y, Hayashi H, Kamoi K. Effects on the healing of tricalcium phosphate- collagen complex implants in periodontal osseous defects in the dog. J Periodontol Res 1990;25:60-63   DOI
32 Laurencin CT, Attawia MA, Elgendy HE, Herbert KM: Tissue engineered bone regeneration using degradable polymers: The formation of mineralized matrices. Bone 1996;93-99
33 White EW, Weber JW, Roy DM, Owen EL, Chiroff RT, White RA. Replamineform porous biomaterials for hard tissue implant applications. J Biomed Mater Res Symp 1975;6:23-28
34 Ganeles J, Listgarten MA, Evian CI. Ultrastructure of durapatite-periodontal tissue interface in human intrabony defects. J Periodontol 1986;57:133-140   DOI
35 Kim S: Bioresorbable calcium mataphosphate ceramics: I. Preparation and preliminary in vitro study. Biomaterials Research 1998;2:48-52
36 Carranza FA Jr, Kenny EB, Lekovic V, Talamante E, Valencia J and Dimitrijevic B: Histologic study of the healing of human periodontal defect after placement of porous hydroxyapatite implants. J Periodontol 1987;58:682-688   DOI
37 Yukna RA: Synthetic grafts and regeneration. In Polson AM. eds. Periodontal regeneration. Current status and directions. pp103-112, Quentessence Publishing Co., Inc, Chicago, 1994
38 설양조, 이재일, 이용무, 임윤탁, 김석영, 구영, 류인철, 함병도, 한수부, 최상묵, 정종평 : Biologic activities of calcium polyphosphate . 대한치주과학회지 2000; 30:213-218
39 Goshima J, Victor MG, Caplan AI: The osteogenic potential of culture-expanded rat marrow mesenchymal cells assayed in vivo in calcium phosphate ceramic blocks. Clin Orthop 1991;298-311
40 Bissada NF, Hangorsky U. Alveolar bone induction: Alloplasts. Dent Clin N Am 1980;24:739-749
41 Ashman A, Bruin P. Prevention of alveolar bone loss postextraction with HTR grafting materials. Oral Surg Oral Med Oral Pathol 1985;60:146-153   DOI   ScienceOn
42 Stahl SS, Froum SJ, Tarnow DP: Human clinical and histologic responses to the placement of HTR polymer particles in 11 intrabony lesion. J Periodontol 1990;61:269-274   DOI
43 Froum SJ: Human histologic evaluation of HTR polymer and freeze-dried bone allograft. A case report. J Clin Periodontol 1996;23:615-620   DOI   ScienceOn
44 Sapokos SW: The use of Periograf in periodontal defects- Histologic findings. J Periodontol 1986;57:7-13   DOI
45 Stahl SS, Froum SJ: Histologic evaluation of human intraosseous healing response to the placement of tricalcium phosphate ceramic implants. J Periodontol 1986;57:211-217   DOI
46 Yukna RA: Clinical evaluation of HTR polymer bone replacement grafts in human mandibular Class II molar furcations. J Periodontol 1994;65:342-349   DOI   ScienceOn
47 Alderman NE. Sterile plaster of Paris as an implant in the infrabony environment. A preliminary study. J Periodontol 1969;40:11-13   DOI
48 Kamen PR. Attachment of oral fibroblasts to HTR polymer. Compend Supp 1988;10:S350-S352
49 Yukna RA: Clinical evaluation of coralline carbonate as a bone replacement graft material in human periodontal osseous defects. J Periodontol 1994;65:177-185   DOI   ScienceOn
50 Zander HA, Polson AM, Heijl LC. Goals of periodontal therapy. J Periodontol 1976;47:261-266   DOI
51 Griffith, EJ. Acicular, Crystalline Calcium Metaphosphate. U.S. Patent 1982;4:360,625
52 Bell R, Beirne O. Effect of hydroxyapatite, tricalcium phosphate, and collagen on the healing of defects in the rat mandible. J Oral Maxillofac Surg 1988;46:589-594   DOI   ScienceOn
53 Sudo H, Kodama HA, Amagai Y, Itaku Y, Yamamoto S: Mineralized tissue formation by MC3T3-E1 osteogenic cells embeded in three dimensional gel matrix, In Cell Mediated Calcification and Matrix Vesicles. pp291-296, SY Ali ed. Elsevier Science, Oxford, UK, 1986
54 Casser-Bette M, Murray AB, Closs EI, Erfle V, Schmidt J: Bone formation by osteoblast-like cells in a three-dimensional cell culture. Calcif Tissue Int 1990;46:46-56   DOI   ScienceOn
55 Laurencin CT, El-Amin SF, Ibim SE, Willough DA, Attawia M, Allock HR, Ambrocio AA: A highly porous 3-dimensional polyphosphazene polymer matrix for skeletal tissue regeneration. J Biomed Mater Res 1996;30:133-138   DOI
56 Cooper ML, Hansbrough JF, Spielvogel RL, Cohen R, Bartel RL, Naughton G: In vivo optimization of a living dermal substitute employing cultured human fibroblasts on a biodegradable polyglycolic acid or polyglactin mesh. Biomaterials 1991;12:243-248   DOI   ScienceOn
57 Goshima J, Goldberg VM, Caplan AI: The origin of bone in composite grafts of porous calcium phosphate ceramic loaded with marrow cells. Clin Orthop 1991;274-283