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http://dx.doi.org/10.5395/JKACD.2010.35.4.295

ANALYSIS OF PARA-CHLOROANILINE AFTER CHEMICAL INTERACTION BETWEEN ALEXIDINE AND SODIUM HYPOCHLORITE USING MASS SPECTROMETRY  

Kim, Hyeon-Sik (Department of Conservative Dentistry, School of Dentistry, Seoul National University)
Han, Seung-Hyun (Oral Microbiology and Immunology, School of Dentistry, Seoul National University)
Oh, So-Ram (Department of Conservative Dentistry, School of Dentistry, Seoul National University)
Lim, Sang-Min (Department of Conservative Dentistry, School of Dentistry, Seoul National University)
Gu, Yu (Department of Conservative Dentistry, School of Dentistry, Seoul National University)
Kum, Kee-Yeon (Department of Conservative Dentistry, School of Dentistry, Seoul National University)
Publication Information
Restorative Dentistry and Endodontics / v.35, no.4, 2010 , pp. 295-301 More about this Journal
Abstract
Recent studies demonstrated that the combination of chlorhexidine (CHX) and sodium hypochlorite (NaOCl) resulted in the formation of a precipitate, para-chloroaniline (PCA). Alexdidine (ALX) is a kind of biguanides like CHX, and has stronger detoxification effect against the bacterial virulence factors such as lipoteichoic acid and lipopolysacchardide compared with CHX. The purpose of this study was to determine whether PCA was formed after chemical interaction between ALX and NaOCl using mass spectrometry. Mass spectrometry was performed for the mixture of five different concentrations of ALX (1, 0.5, 0.25, 0.125, 0.0625%) and 4% NaOCl. Results showed that the peak of PCA was not detected in mixed solutions of ALX and NaOCl in mass spectrometry analysis. The color of mixed solution of ALX and NaOCl after chemical interaction was light yellow to white, but there wasn't any precipitate found.
Keywords
Alexidine; Chemical interaction; Mass spectrometry; Para-chloroaniline; Sodium hypochlorite;
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Times Cited By KSCI : 2  (Citation Analysis)
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