2011.09a
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The amyloid
${\beta}$ -peptide ($A{\beta}$ ), which originates from the proteolytic cleavage of amyloid precursor protein (APP), plays a central role in the pathogenesis of Alzheimer's disease (AD). Mounting evidence indicates that different species of$A{\beta}$ , such as$A{\beta}$ oligomers and fibrils, may contribute to AD pathogenesis via distinct mechanisms at different stages of the disease. Importantly, elevation and accumulation of soluble$A{\beta}$ oligomers closely correlate with cognitive decline and/or disease progression in animal models of AD. In agreement with these studies, oligomers of$A{\beta}$ have been shown to directly affect synaptic plasticity, a neuronal process that is known to be essential for memory formation. Our previous studies showed that$A{\beta}$ induces the breakdown of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a phospholipid that regulates key aspects of neuronal function. PI(4,5)P2 breakdown was found to be a key step toward synaptic and memory dysfunction in a mouse model of AD. To this end, we seek to identify small molecules that could elevate the levels of PI(4,5)P2 and subsequently block$A{\beta}$ oligomer-induced breakdown of PI(4,5)P2 and synaptic dysfunction.. We found that (20S)Rg3, an active triterpene glycoside from heat-processed ginseng, serves as an agonist for phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha), which is a lipid kinase that mediates a rate-limiting step in PI(4,5)P2 synthesis. Consequently, (20S)Rg3 stimulates PI(4,5)P2 synthesis by directly stimulating the activity of PI4KIIalpha. Interestingly, treatment of a mouse model of AD with (20S)Rg3 leads to reversal of memory deficits. Our data suggest that the PI(4,5)P2-promoting effects of (20S)Rg3 may help mitigate the cognitive symptoms associated with AD. -
Devi, Balusamy Sri Renuka;Lee, Ok-Ran;Gayathri, Sathiyaraj;Altanzul, Khorolragchaa;Parvin, Shohana;Kim, Yu-Jin;Yang, Deok-Chun 82
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Park, Seong-Yong;Jang, Yun-Gi;Lee, Gyong-A;Jeong, Tae-Seong;Heo, Su-Jeong;Jeong, Haet-Nim;Lee, Sung-Woo;Cha, Seon-Woo;Song, Beom-Heon 86
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Baek, Hyeon;Park, Hea-li;Bae, Hui-Ae;Sim, Hun-Sub;Lee, Beom-Goo;Lee, Jae-Geun;Yu, Chang-Yeon;Lim, Jung-Dae 88
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Lee, Young-Seob;Han, Sin-Hee;Lee, Su-Hwan;Kim, Young-Guk;Park, Chung-Berm;Mun, Su-Hyun;Kim, Sung-Bae;Keum, Joon-Ho;Kang, Ok-Hwa;Kwon, Dong-Yeul 92
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Yeo, Jun-Hwan;Cho, Hyun-Woo;Ham, Seong-Ho;Cho, Jung-Hee;Kang, Byoung-Man;Park, Chung-Berm;Ahn, Young-Sup 106
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Kang, Byoung-Man;Cho, Hyun-Woo;Ham, Seong-Ho;Cho, Jung-Hee;Yeo, Jun-Hwan;Park, Chung-Berm;Ahn, Young-Sup 108
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Seo, Joung-Seok;Lee, Bo-Hee;Ju, Jung-Il;Nam, Yun-Gyu;Ahn, Young-Sup;Park, Chung-Berm;Song, Hong-Seon 110
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Lee, Jae-Geun;Yoo, Ji-Hye;Seong, Eun-Soo;Kim, Nam-Jun;Hwang, In-Seong;Yu, Chang-Yeon;Kwon, Soon-Sung;Kim, Jung-Duk;Choi, Seon-Kang;Sim, Jae-Man;Kil, Hyun-Young 112
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Choi, Jin-Kook;Jang, Myeung-Hwan;Jung, Won-Kwon;Ahn, Deok-Jong;Kwon, Tae-Ryong;Lee, Sang-Chul 114
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Hwang, In-Seong;Lee, Jae-Geun;Yoo, Ji-Hye;Seong, Eun-Soo;Kim, Nam-Jun;Kim, Myong-Jo;Lim, Jung-Dae;Yu, Chang-Yeon 116
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Lee, Sung-Woo;Kim, Gum-Sook;Hyun, Dong-Yun;Kim, Yong-Burm;Kim, Jang-Wook;Kang, Seung-Won;Cha, Seon-Woo 118
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Yoo, Ji-Hye;Hwang, In-Seong;Kim, Nam-Jun;Seong, Eun-Soo;Lee, Jae-Geun;Heo, Kweon;Lim, Jung-Dae;Yu, Chang-Yeon;Ham, Jin-Kwan 120
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Kim, Nam-Jun;Yoo, Ji-Hye;Hwang, In-Seong;Seong, Eun-Soo;Lee, Jae-Geun;Kim, Myong-Jo;Lim, Jung-Dae;Yu, Chang-Yeon;Ham, Jin-Kwan 122
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Ryu, Si-Hwan;Jeong, Tae-Sung;Heo, Su-Jeong;Jeong, Haet-Nim;Kim, Kyung-Hi;Ham, Jin-Kwan;Cho, Dong-Ha 126
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Ham, Jin-Kwan;Ryu, Si-Hwan;Jeong, Tae-Sung;Heo, Su-Jeong;Jeong, Haet-Nim;Kim, Kyung-Hi;Seo, Jeong-Sik;Cho, Dong-Ha 128
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Kim, Dong-Won;Kim, Jong-Yeob;You, Dong-Hyun;Kim, Chang-Su;Kim, Hee-Jun;Park, Jong-Suk;Kim, Jeong-Man;Lee, Kang-Soo 134
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Heo, Su-Jeong;Jeong, Tae-Sung;Jeong, Haet-Nim;Ham, Jin-Kwan;Ryu, Si-Hwan;Ha, Keon-Soo;Kim, Kyung-Hee 138
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Kim, Myeong-Seok;Choi, Jin-Gyung;Kim, Dong-Kwan;Kim, Joung-Keun;Shin, Hae-Ryong;Choi, Gyung-Ju;Park, Min-Soo;Shim, Jae-Han 140
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Kim, Myeong-Seok;Choi, Jin-Gyung;Kim, Dong-Kwan;Kim, Joung-Keun;Shin, Hae-Ryong;Choi, Gyung-Ju;Park, Min-Soo;Shim, Jae-Han 142
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Lee, Gyong-A;Park, Seong-Yong;Wu, Wen-Guo;Kim, Do-Hyun;Song, Beom-Heon;Ahn, Young-Sub;Park, Chung-Berm 144
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Lee, Gyong-A;Park, Seong-Yong;Wu, Wen-Guo;Kim, Min-Su;Song, Beom-Heon;Ahn, Young-Sub;Park, Chung-Berm 146
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Lee, Gyong-A;Park, Seong-Yong;Wu, Wen-Guo;Jang, Yun-Gi;Kim, Do-Hyun;Song, Beom-Heon;Park, Kee-Choon;Cha, Sun-Woo 148
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Lee, Gyong-A;Park, Seong-Yong;Wu, Wen-Guo;Jang, Yun-Gi;Hwang, Hye-Young;Song, Beom-Heon;Park, Kee-Choon;Cha, Sun-Woo 150
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Seong, Bong-Jae;Kim, Sun-Ick;Han, Seung-Ho;Kim, Hyun-Ho;Lee, Ka-Soon;Kim, Gwan-Hou;Kim, Hong-Gi;Won, Jun-Yeon 154
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Song, Sung-Hyun;Jung, Suk-Jun;Kwon, Jung-Woong;Chung, Il-Min;Park, Hae-Il;Yu, Chang-Yeon;Lim, Jung-Dae 156
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Park, Hae-Il;Baek, Hyeon;Bae, Hui-Ae;Hwang, In-Sung;Yu, Chnag-Yeon;Ham, Jin-Kwan;Lim, Jung-Dae 158
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Park, Hae-Il;Baek, Hyeon;Bae, Hui-Ae;Yu, Chang-Yeon;Hwang, In-Sung;Ham, Jin-Kwan;Kim, Keyung-Hee;Lim, Jung-Dae 160
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Sim, Su-Jin;Kim, Hak-Jong;Jung, Chan-Moon;Kim, Ha-Neul;Kim, Mi-Ra;Kim, Byung-Ro;Ahn, Young-Sup;Hwang, Sung-Jin 168
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Effect of Cefotaxime and Augmentin on Plant Regeneration from Leaf Explants of Digitalis purpurea L.Sim, Su-Jin;Kim, Mi-Ra;Kim, Hak-Jong;Jung, Chan-Moon;Kim, Ha-Neul;Kim, Byung-Ro;Hwang, Sung-Jin 170
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Kim, Mi-Ra;Kim, Ha-Neul;Sim, Su-Jin;Kim, Hak-Jong;Jung, Chan-Moon;Kim, Byung-Ro;Ahn, Young-Sup;Hwang, Sung-Jin 172
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Kim, Ha-Neul;Kim, Hak-Jong;Jung, Chan-Moon;Sim, Su-Jin;Kim, Mi-Ra;Kim, Byung-Ro;Hwang, Sung-Jin 174
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Jung, Chan-Moon;Kim, Hak-Jong;Sim, Su-Jin;Kim, Ha-Neul;Kim, Mi-Ra;Kim, Byung-Ro;Ahn, Young-Sup;Hwang, Sung-Jin 176
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Lee, Su-Hwan;Kim, Young-Guk;Han, Sin-Hee;Lee, Young-Seob;Song, Seok-Bo;Song, Beom-Heon;Park, Chung-Berm 178
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Kim, Jong-Yeob;You, Dong-Hyun;Kim, Dong-Won;Kim, Chang-Su;Kim, Jeong-Man;Kim, Young- Guk;An, Young-Seob 182
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Lee, Jeong-Hoon;Park, Chung-Berm;Park, Chun-Geon;Woo, Jong-Gyu;Kang, Yong-Ku;Choi, Ae-Jin;Kim, Yong-Joo;Lee, Sang-Hoon;Kim, Seong-Min 188
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Park, Hong-Woo;Kim, Young-Chang;Kim, Jang-Uk;Kim, Yong-Bum;Kang, Seung-Weon;Cha, Seon-Woo;Hyun, Dong-Yun 192
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Nam, Sang-Young;Kim, In-Jae;Kim, Min-Ja;Choi, Seong-Yel;Kim, Young-Ho;Lee, Guang-Jae;Park, Jae-Ho;Song, Beom-Heon 194
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Sung, Jung-Sook;Sundan, Suresh;Chung, Jong-Wook;Park, Jong-Hyun;Cho, Gyu-Taek;Baek, Hyung-Jin 204
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Bang, Kyong-Hwan;Jo, Ick-Hyun;Kim, Young-Chang;Seo, A-Yeon;Kim, Ok-Tae;Hyun, Dong-Yun;Kim, Dong-Hwi;Cha, Seon-Woo 208
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Seo, A-Yeon;Bang, Kyong-Hwan;Jo, Ick-Hyun;Kim, Young-Chang;Kim, Dong-Hwi;Cha, Seon-Woo;Kim, Hong-Sig 210
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Jo, Ick-Hyun;Bang, Kyong-Hwan;Seo, A-Yeon;Kim, Young-Chang;Kim, Dong-Hwi;Cha, Seon-Woo;Kim, Hong-Sig 212
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Kang, Yong-Ku;Kim, Geum-Soog;Park, Chung-Berm;Choi, Ae-Jin;Lee, Jeong-Hoon;Han, Sin-Hee;Woo, Jong-Gyu;Lee, Sang-Hoon;Park, Chun-Geon;Han, Seung-Ho;Kim, Jae-Cheol;Jeong, Eun-Ho 214
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Park, Chun-Geon;Park, Chung-Berm;Woo, Jong-Gyu;Kang, Yong-Ku;Choi, Ae-Jin;Lee, Jeong-Hoon;Kim, Seong-Min 216
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Kwak, Jae-Sung;Kim, Kyoung-Sook;Moon, Hyung-In;Yu, Hai-Yang;Kim, Kyung-Mi;Cho, Chang-Woo;So, Hyun-Ah;Chung, Eun-Sook;Ayarpadikannan, Salvem;Lee, Young-Choon;Lee, Jai-Heon 232
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Yu, Hai-Yang;Jin, Cheng-Yun;Kim, Kyoung-Sook;Moon, Hyung-In;Choi, Yung-Hyun;Lee, Young-Choon;Lee, Jai-Heon 234
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Yu, Hai-Yang;Kim, Kyoung-Sook;Moon, Hyung-In;Kim, Kyung-Mi;Kwak, Jae-Sung;Cho, Chang-Woo;So, Hyun-Ah;Chung, Eun-Sook;Ayarpadikannan, Salvem;Lee, Young-Choon;Lee, Jai-Heon 236
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Yu, Hai-Yang;Kim, Kyoung-Sook;Moon, Hyung-In;Kwak, Jae-Sung;Kim, Kyung-Mi;Cho, Chang-Woo;So, Hyun-Ah;Chung, Eun-Sook;Ayarpadikannan, Salvem;Lee, Young-Choon;Lee, Jai-Heon 238
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Lee, Seung-Eun;Kim, Geum-Soog;Lee, Jeong-Hoon;Kang, Yong-Ku;Lee, Eun-Suk;Choi, Je-Hun;Lee, A-Reum;Noh, Hyung-Jun;Kim, Seung-Yu 242
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Lee, Seung-Eun;Kim, Geum-Soog;Kim, Young-Ok;Park, Chun-Geun;Lee, Eun-Suk;Kim, Young-Chul;Cha, Sun-Woo;Kim, Seung-Yu 244
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Mok, So-Youn;Kim, Hye-Min;Lee, Jeong-Min;Lee, Dong-Gu;Lee, Sang-Hyun;Cho, Eun-Joo;Kim, Hyun-Young 250
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Kim, Hye-Min;Lee, Jeong-Min;Lee, Dong-Gu;Mok, So-Youn;Lee, Sang-Hyun;Cho, Eun-Joo;Choi, Kyung;Ku, Ja-Jung;Park, Kwang-Woo 254
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Hong, Seong-Su;Jeong, Won-Sik;Song, Ji-Yeon;Na, Da-Hye;Lee, Jea-Yeon;Ahn, Eun-Kyung;Oh, Joa-Sub 262
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Lee, Ka-Soon;Kim, Gwan-Hou;Kim, Hyun-Ho;Seong, Bong-Jae;Kim, Sun-Ick;Han, Seung-Ho;Yun, Byeong-Ha 270
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Yong, Soo-Jung;Park, Jin-Hee;Kwon, Jung-Woong;Song, Sung-Hyun;Jang, Mi-So;Kim, Ha-Jung;Lee, Ye-Ji;Jung, Suk-Jun;Chung, Ill-Min 274
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Kim, Ha-Jung;Kwon, Jung-Woong;Kim, Sun-Jin;Kim, Eun-Hye;Song, Sung-Hyun;Yong, Soo-Jung;Jang, Mi-So;Lee, Ye-Ji;Jung, Suk-Jun;Chung, Ill-Min 280
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Jung, Suk-Jun;Kim, Eun-Hye;Kim, Seok-Ju;Kwon, Jung-Woong;Song, Sung-Hyun;Yong, Soo-Jung;Jang, Mi-So;Lee, Ye-Ji;Kim, Ha-Jung;Yu, Chang-Yeon;Song, Hong-Keun;Ahn, Jong-Guk;Chung, Ill-Min 282
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Song, Sung-Hyun;Kim, Eun-Hye;Kwon, Jung-Woong;Yong, Soo-Jung;Jung, Suk-Jun;Lee, Ye-Ji;Kim, Ha-Jung;Song, Hong-Geun;An, Jong-Guk;Chung, Ill-Min 284
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Lee, Hee-Jung;Park, Chung-Berm;Woo, Jong-Gyu;Park, Chun-Geon;Kang, Yong-Ku;Lee, Jeong-Hoon;Kim, Chong-Tai;Kim, Seong-Min;Choi, Ae-Jin 286
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Lee, Ye-Ji;Kim, Eun-Hye;Kwon, Jung-Woong;Song, Sung-Hyun;Yong, Soo-Jung;Jang, Mi-So;Jung, Suk-Jun;Kim, Ha-Jung;Chung, Ill-Min 288
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Cheon, Jin-Heok;Lee, Dong-Gu;Lee, Sang-Hyun;Lee, Dong-Hun;Jeong, Beong-Gwan;Lee, Heon-Sam;Yun, Ji-Hye;Lee, Jong-Won;Kim, Sun-Ju 290
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Hwang, Yu-Jin;Kim, In-Hye;Woo, Hye-Im;Hwang, Sung-Jun;Park, Dong-Sik;Kim, Jae-Hyun;Hwang, Kyung-A 292
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Kim, Moung-Su;Jang, Hye-Ri;Khoa, Hoang Viet Bach;Byeon, Ji-Hui;Lim, Jong-Min;Cho, Joon-Hyeong 296
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Kang, Tong-Ho;Moon, Eun-Jung;Hong, Bin-Na;Kim, May;Lee, Mi-Kyeong;Lee, Jae-Hak;Kim, Sun-Yeou 298
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Park, Seong-Yong;Jang, Yun-Gi;Lee, Gyong-A;Jeong, Tae-Seong;Heo, Su-Jeong;Jeong, Haet-Nim;Lee, Sung-Woo;Cha, Seon-Woo;Song, Beom-Heon 320
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Kim, Hak-Jong;Jung, Chan-Moon;Kim, Ha-Neul;Sim, Su-Jin;Kim, Mi-Ra;Kim, Byung-Ro;Ahn, Young-Sup;Hwang, Sung-Jin 322
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Kim, Ha-Neul;Sim, Su-Jin;Kim, Hak-Jong;Jung, Chan-Moon;Kim, Mi-Ra;Kim, Byung-Ro;Ahn, Young-Sup;Hwang, Sung-Jin 324
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Lee, Kwang-Jae;Kim, Hee-Yeon;Lim, Sang-Hyun;Park, Min-Hee;Park, Yu-Hwa;Kim, Kyung-Hee;Kim, Young-Guk;Ahn, Young-Sup 330
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Choi, Eun-Young;Yang, Jinfeng;Jeong, Hyun-Ju;Kim, Joo-Seok;Kim, Myong-Jo;Heo, Seong-Il;Kang, Hak-Hee;Cho, Jun-Cheol;Yeom, Myeong-Hun 346
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Jung, Hyun-Ju;Yang, Jinfeng;Choi, Eun-Yong;Kim, Joo-Seok;Yu, Chang-Yeon;Kim, Myong-Jo;Heo, Seong-Il 348
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Kim, Joo-Seok;Jung, Hyun-Ju;Yang, Jin-Feng;Choi, Eun-Yong;Sa, Yeo-Jin;Yu, Chang-Yeon;Kim, Mying-Jo;Heo, Seong-Il;Pack, Dong-Sik;Chung, Ill-Min 350
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Seo, Yong-Chang;Kim, Ji-Seon;Lee, Hyeon-Yong;Choi, Woon-Yong;Jeong, Myoung-Hoon;Yim, Tae-Bin;Cho, Jeong-Sub;Kim, Sung-Il;Yoon, Won-Byung 352
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Han, Sin-Hee;Lee, Young-Seob;Lee, Su-Hwan;Kim, Young-Guk;Park, Chung-Berm;Mun, Su-Hyun;Kim, Sung-Bae;Keum, Joon-Ho;Kang, Ok-Hwa;Kwon, Dong-Yeul 356
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Bae, Hui-Ae;Baek, Hyeon;Park, Hae-Il;Sim, Hun-Seop;Lim, Jung-Dae;Yu, Chang-Yeon;Cheoi, Dae-Sung;Cheoi, Yu-Soon;Chung, Ill-Min;Park, Yeong-Cheol 364
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Yoo, Ki-Hyun;Cui, En-Ji;HwangBo, Jeon;Park, Jong-Hwa;Kim, Ji-Young;Hong, Seong-Gil;Baek, Nam-In;Chung, In-Sik 368
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Lee, Hyun-Ho;Chung, Ha-Young;Park, Jong-Hwa;Kim, Jong-Bum;Shon, Dong-Hwa;Kim, Won-Yong;Chung, In-Sik 370
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Shim, Hun-Seob;Bae, Hui-Ae;Park, Hae-Il;Baek, Hyeon;Lim, Jung-Dae;Yu, Chnag-Yeon;Cheoi, Dae-Sung;Cheoi, Yu-Soon;Chung, Ill-Min;Park, Young-Cheol 394
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