This study analyzes the current status of research on integrative medicine combining traditional East Asian medicine (TEAM) and Western medicine (WM) using artificial intelligence and data science approaches, with a focus on diagnostic applications. Through a comprehensive literature review, we identified and categorized relevant studies into three types: 1) models utilizing both TEAM and WM information for various diagnoses, 2) studies performing Western medical diagnoses based on TEAM information, and 3) research analyzing the correlation between TEAM diagnoses and Western medical information. For each category, we summarized the research objectives, sample sizes, collected TEAM and WM factors, integration methods, and key results in terms of the benefits of integrative medicine. Our analysis revealed that integrating TEAM and WM information often led to improved diagnostic accuracy and more comprehensive patient profiles compared to single-system approaches. However, we also identified several limitations in current research, including small sample sizes, lack of external validation, and difficulties in standardizing TEAM data. Based on our findings, we propose future research directions to address these limitations, such as conducting larger-scale prospective cohort studies, developing standardized methods for collecting and digitizing TEAM data, and investigating the underlying physiological mechanisms of observed correlations between TEAM and Western medical factors. This review provides valuable insights into the current state and future potential of data-driven integrative medicine research, highlighting its promise in enhancing diagnostic accuracy and patient-centered care.

The study aimed to evaluate the effects of mixed extracts of Hericium erinaceus and red ginseng on immune function activation. Splenocytes from Balb/c mice were used to assess the cytotoxicity and immune cell activity of Hericium erinaceus extract, Korean red ginseng extract, and their mixed extract (HRM). The concentrations of IL-2, IL-4, IL-12, and INF-γ were measured in various treatment groups. Hericium erinaceus extract showed cytotoxicity at high concentrations (HEE 400), with increased secretion of IL-2, IL-4, IL-12, and INF-γ in a concentration-dependent manner. Korean red ginseng extract and HRM also showed a concentration-dependent increase in these cytokines. Notably, IL-2, IL-4, and INF-γ were significantly higher in the RGE 400 and HRM 400 groups compared to the ConA group, and IL-12 was significantly higher in the RGE 400 group compared to the Normal and ConA groups. The study suggests that combined extracts of Koran Red ginseng and Hericium Erineceus may be more effective than single extracts in activating immune function, but further studies are needed to determine safety and human applicability.

Tanshinone IIA (TIIA), known as a major constituent of Salvia miltiorrhiza Bunge, exhibits anti-inflammatory and anti-osteoporotic activities. In this study, we investigated the effects of TIIA and its regulatory mechanism on osteoclast and osteoblast differentiation. TIIA significantly inhibited the formation of TRAP(+)-mature osteoclasts and resorption pits in a dose-dependent manner. The expression of the osteoclast differentiation marker genes and activation of JNK, p38, and IκB were remarkably suppressed by TIIA during osteoclastogenesis. In addition, TIIA removed RANKL-induced Ca²⁺ oscillations through sequential inactivation of Bruton's tyrosine kinase (BTK) and phospholipase C gamma (PLCγ1 and 2). Consequently, the expression of pivotal transcription factors in osteoclastogenesis, c-Fos and nuclear factor of activated T-cells cytoplasmic 1 (Nfatc1), was remarkably decreased. By contrast, TIIA stimulated the expression of osteoblast differentiation markers and transcription factors including Runx2, resulting in increased nodule formation. Interestingly, TIIA dose-dependently suppressed osteoclast formation in coculture with bone marrow cells (BMs) and osteoblasts via inhibiting the expression of Rankl and Csf-1 (M-csf) on osteoblasts. These findings indicate that TIIA serves as a dual modulator of bone remodeling, suppressing osteoclast-mediated resorption while enhancing osteoblast-mediated formation, thereby supporting its potential as a therapeutic candidate for resorptive bone diseases.