Animal Bioscience

  • 제39권7호
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  • Pages.250822.1-250822.11
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  • 2026
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  • 2765-0189(pISSN)
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  • 2765-0235(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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Stewart-based characterisation of blood acid-base recovery over 48 h following exercise under hot condition in camels (Camelus dromedarius)

  • Emad M. Samara (Department of Animal Production, College of Food and Agriculture Sciences, King Saud University) ;
  • Khalid A. Abdoun (Department of Animal Production, College of Food and Agriculture Sciences, King Saud University) ;
  • Mohammed A. Al-Badwi (Department of Animal Production, College of Food and Agriculture Sciences, King Saud University) ;
  • Majdi A. Bahadi (Department of Animal Production, College of Food and Agriculture Sciences, King Saud University) ;
  • Ahmed A. Al-Haidary (Department of Animal Production, College of Food and Agriculture Sciences, King Saud University)
  • 투고 : 2025.10.28
  • 심사 : 2026.03.11
  • 발행 : 2026.07.01
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초록

Objective: Exercise in desert heat disturbs respiratory and metabolic balance in camels. Unlike the Henderson-Hasselbalch model, which focuses mainly on bicarbonate and carbon dioxide, Stewart's physicochemical approach clarifies acid-base regulation through strong-ion and weak-acid effects. This experiment investigated post-exercise acid-base recovery dynamics in exercise-unacclimatized dromedary camels under hot field conditions using Stewart's approach. Methods: Five healthy bull camels completed a standardized 90-min field exercise at approximately 14 km·h-1 during midday heat. Recovery was monitored at baseline (2 h preexercise), and at 0, 3, 6, 24, and 48 h post-exercise. Sixteen respiratory, strong-ion, and weak-acid variables were measured or derived, together with biometeorological indices and ventilatory responses. Visualization tools were used to resolve temporal dynamics and inter-individual variability. Results: Heat load was greatest at PRE/0 h and again at 24-48 h, with a transiently cooler but more humid interval at 3-6 h. A triphasic recovery pattern was evident. Immediately post-exercise (0 h), respiratory rate increased sharply, while pH showed mild alkalinization with reduced partial pressure of carbon dioxide, bicarbonate, and base excess, alongside reduced oxygenation indices and early strong-ion shifts. During early recovery (3-6 h), respiratory rate declined toward baseline, but sodium excursions, hypokalemia, hypophosphatemia (p<0.05), widened apparent strong-ion difference, contracted effective strongion difference, and positive strong-ion gap persisted. By late recovery (24-48 h), respiratory variables largely normalized, whereas sodium instability, sustained potassium and phosphate depression (p<0.05), and renewed strong-ion gap elevation indicated incomplete systemic restoration. Conclusion: Stewart analysis revealed prolonged post-exercise disequilibrium driven mainly by persistent strong-ion and weak-acid disturbances rather than respiratory adjustment alone. In this small cohort of exercise-unacclimatized dromedary camels, recovery after exertional heat exposure cannot be assumed complete within 24 h, and environmental cooling did not ensure systemic normalization. Monitoring strong-ion and protein-phosphate domains may therefore complement conventional blood gas assessment.

키워드

과제정보

This work was supported by the Ongoing Research Funding program (ORF-2026-1096), King Saud University, Riyadh, Saudi Arabia.

참고문헌

  1. Zappaterra M, Menchetti L, Nanni Costa L, Padalino B. Do camels (Camelus dromedarius) need shaded areas? A case study of the camel market in Doha. Animals 2021;11:480. https://doi.org/10.3390/ani11020480
  2. Ashour G, El Bahrawy K, Abdel-Rahman SM. Climate change and camels: exploring adaptations to harsh conditions. Egypt J Camel Sci 2024;2:63-72. https://doi.org/10.21608/ejcs.2025.336975.1023
  3. Bengoumi M, Faye B, de la Farge F. Clinical enzymology in the camel (Camelus dromedarius). Part IV: effect of exercise on serum AST, ALT, GGT, AP, LDH and CK activities. In: Gahlot TK, editor. Selected research on camelid physiology and nutrition. The Camelid Publishers; 2004. pp. 303-9.
  4. Zainab AMA, El-Belbasi HI, Hamada MMZ, Yousef MMZ. Some biochemical studies on blood of racing camels. Vet Med J Giza 2005;53:409-22. https://doi.org/10.21608/vmjg.2005.384734
  5. Kirat D, Hamada M, Moustafa A, Miyasho T. Irisin/FNDC5: a participant in camel metabolism. Saudi J Biol Sci 2021;28:693-706. https://doi.org/10.1016/j.sjbs.2020.10.061
  6. Tharwat M. Advanced biomarkers and its usage in Arabian camel medicine: a review. J Appl Anim Res 2023;51:350-7. https://doi.org/10.1080/09712119.2023.2203749
  7. Al-Haidary AA. The effect of physical activity on body temperature and some blood constituents of camel during summer and winter months. Res Bull Agric Res Cent KSU 2006;147:1-17.
  8. Moutaouakil F, Bengoumi M. Plasma thyroid hormones levels after maximal exercise in dromedary camel (Camelus dromedarius). J Camel Pract Res 2007;14:75-8.
  9. Auer RE, Gleiss A, Windberger U. Towards a basic understanding of the properties of camel blood in response to exercise. Emir J Food Agric 2015;27:302-11. https://doi.org/10.9755/EJFA.V27I3.18515
  10. Constable PD. A simplified strong ion model for acid-base equilibria: application to horse plasma. J Appl Physiol 1997;83:297-311. https://doi.org/10.1152/jappl.1997.83.1.297
  11. Stewart PA. Independent and dependent variables of acid-base control. Respir Physiol 1978;33:9-26. https://doi.org/10.1016/0034-5687%2878%2990079-8
  12. Stewart PA. Modern quantitative acid-base chemistry. Can J Physiol Pharmacol 1983;61:1444-61. https://doi.org/10.1139/Y83-207
  13. Story DA. Stewart acid-base: a simplified bedside approach. Anesth Analg 2016;123:511-5. https://doi.org/10.1213/ANE.0000000000001261
  14. Waller A, Lindinger MI. Physicochemical analysis of acid-base status during recovery from high-intensity exercise in Standardbred racehorses. Equine Comp Exerc Physiol 2005;2:119-27. https://doi.org/10.1079/ECP200549
  15. Poškienė I, Juozaitienė V, Gruodytė R, Antanaitis R. The effect of 60 km endurance exercise on serum electrolytes and acid-base balance in the Žemaitukai horses. Acta Vet Brno 2020;89:125-31. https://doi.org/10.2754/avb202089020125
  16. Lindinger MI, Waller AP. Physicochemical analysis of mixed venous and arterial blood acid-base state in horses at core temperature during and after moderate-intensity exercise. Animals 2022;12:1875. https://doi.org/10.3390/ani12151875
  17. Pannu AK, Sharma R, Sharma N, Kaur J, Walia R, Kumar S. Stewart (physicochemical) approach versus conventional anion gap approach for resolution of metabolic acidosis in diabetic ketoacidosis. Int J Diabetes Dev Ctries 2021;41:628-33. https://doi.org/10.1007/s13410-021-00927-7
  18. Chun D, Bae H, Yu D. Comparison of acid-base disorders in cats using traditional, Stewart, and Fencl-Stewart methods. Korean J Vet Serv 2024;47:261-72. https://doi.org/10.7853/kjvs.2024.47.4.261
  19. Elkhair NM. Novel research: acid-base homeostasis in camel calves (Camelus dromedarius) during the postnatal development. Trop Anim Health Prod 2025;57:427. https://doi.org/10.1007/s11250-025-04686-z
  20. Maloiy GMO, Rugangazi BM, Rowe MF. Energy expenditure during level locomotion in large desert ungulates: the one-humped camel and the domestic donkey. J Zool 2009;277:248-55. https://doi.org/10.1111/J.1469-7998.2008.00535.X
  21. Samara EM, Abdoun KA, Okab AB, Al-Haidary AA. Exercise and dehydration minimized bleeding time in camels (Camelus dromedarius): a clinical standpoint. Pak Vet J 2012;32:432-4.
  22. Entin PL, Rawson RE. Arterial blood gas tensions during exercise in neonatal lambs. Respir Physiol 1999;117:161-9. https://doi.org/10.1016/S0034-5687%2899%2900061-4
  23. Davidson JA, Beede DK. Exercise training of late-pregnant and nonpregnant dairy cows affects physical fitness and acid-base homeostasis. J Dairy Sci 2009;92:548-62. https://doi.org/10.3168/jds.2008-1458
  24. Thornton PK, Ericksen PJ, Herrero M, Challinor AJ. Climate variability and vulnerability to climate change: a review. Glob Chang Biol 2014;20:3313-28. https://doi.org/10.1111/gcb.12581
  25. Samara EM, Al-Badwi MA, Abdoun KA, Al-Haidary AA. Proposing a strategy based on body-thermal status to improve the welfare of heat-stressed and water-deprived goats (Capra hircus). Anim Biosci 2024;37:2189-201. https://doi.org/10.5713/ab.24.0096
  26. Travers G, Kippelen P, Trangmar SJ, González-Alonso J. Physiological function during exercise and environmental stress in humans: an integrative view of body systems and homeostasis. Cells 2022;11:383. https://doi.org/10.3390/cells11030383
  27. Tiller NB, Porszasz J, Casaburi R, Rossiter HB, Ferguson C. Critical power and respiratory compensation point are not equivalent in patients with COPD. Med Sci Sports Exerc 2023;55:1097-104. https://doi.org/10.1249/MSS.0000000000003124
  28. Knight PK, Rose RJ, Evans DL, Cluer D, Henckel P, Saltin B. Metabolic responses to maximal intensity exercise in the racing camel. Acta Physiol Scand Suppl 1994;617:61-77.
  29. Rose RJ, Evans DL, Henckel P, Knight PK, Cluer D, Saltin B. Metabolic responses to prolonged exercise in the racing camel. Acta Physiol Scand Suppl 1994;617:49-60.
  30. Sejersted OM, Sjøgaard G. Dynamics and consequences of potassium shifts in skeletal muscle and heart during exercise. Physiol Rev 2000;80:1411-81. https://doi.org/10.1152/physrev.2000.80.4.1411
  31. Dubin A, Menises MM, Masevicius FD, et al. Comparison of three different methods of evaluation of metabolic acid-base disorders. Crit Care Med 2007;35:1264-70. https://doi.org/10.1097/01.CCM.0000259536.11943.90