DOI QR코드

DOI QR Code

First Report of KPC-2-Producing Hafnia paralvei: Evidence of Horizontal Gene Transfer from Klebsiella pneumoniae

  • Sun-mi Cho (Department of Laboratory Medicine, CHA Bundang Medical Center, CHA University) ;
  • Myung Seo Kang (Department of Laboratory Medicine, CHA Bundang Medical Center, CHA University) ;
  • Seong Geun Hong (Department of Laboratory Medicine, CHA Bundang Medical Center, CHA University)
  • Received : 2025.09.01
  • Accepted : 2026.01.13
  • Published : 2026.05.01

Abstract

Keywords

Acknowledgement

This work was supported by the Korea Medical Device Development Fund (grant no. RS-2020-KD000020).

References

  1. Huys G, Cnockaert M, Abbott SL, Janda JM, Vandamme P. Hafnia paralvei sp. nov., formerly known as Hafnia alvei hybridization group 2. Int J Syst Evol Microbiol 2010;60:1725-8. https://doi.org/10.1099/ijs.0.018606-0
  2. Ramos-Vivas J. Microbiología de Hafnia alvei [Microbiology of Hafnia alvei]. Enferm Infecc Microbiol Clin (Engl Ed) 2020;38(S1):1-6. https://doi.org/10.1016/j.eimc.2020.02.001
  3. Skurnik D, Nucci A, Ruimy R, Lasocki S, Muller-Serieys C, Montravers P, et al. Emergence of carbapenem-resistant Hafnia: The fall of the last soldier. Clin Infect Dis 2010;50:1429-31. https://doi.org/10.1086/649517
  4. Appel TM, Stein C, Brandt C, Rödel J, Frietsch JJ, Miethke J, et al. Isolation of Hafnia paralvei co-harbouring blaNDM-1 and blaVIM-1 in a woman who underwent allogeneic hematopoietic stem cell transplantation. Infection 2023;51:1161-4. https://doi.org/10.1007/s15010-022-01976-8
  5. Sevillano L, Herrera C, Valdes Á, de La Hoz Á, Cardeñoso L, Domingo D, et al. First report of a carbapenemase OXA-48-producing Hafnia alvei clinical isolate. Access Microbiol 2023;5:acmi000498.v3.
  6. CLSI. Performance standards for antimicrobial susceptibility testing. 34th ed. CLSI M100. Wayne. PA: Clinical and Laboratory Standards Institute, 2024.
  7. Fronzes R, Christie PJ, Waksman G. The structural biology of type IV secretion systems. Nat Rev Microbiol 2009;7:703-14. https://doi.org/10.1038/nrmicro2218
  8. Guo X, Chen R, Wang Q, Li C, Ge H, Qiao J, et al. Global prevalence, characteristics, and future prospects of IncX3 plasmids: A review. Front Microbiol 2022;13:979558. https://doi.org/10.3389/fmicb.2022.979558
  9. Chen L, Mathema B, Chavda KD, DeLeo FR, Bonomo RA, Kreiswirth BN. Carbapenemase-producing Klebsiella pneumoniae: Molecular and genetic decoding. Trends Microbiol 2014;22:686-96. https://doi.org/10.1016/j.tim.2014.09.003
  10. Kang Y, Son E, Han K, Cho M, Choi S, Kim YJ, et al. Whole-genome and targeted sequencing of 75 drug-resistant Mycobacterium tuberculosis clinical isolates in South Korea. Ann Lab Med. 2025 Dec 9. doi: 10.3343/alm.2025.0372. Epub ahead of print.