Annals of Laboratory Medicine

Korean Society for Laboratory Medicine (대한진단검사의학회)
권호 표지
DOI QR코드

DOI QR Code

Rapid-onset Antibody-mediated Renal Allograft Rejection Caused by HLA-Bw4

  • Hae In Bang (Department of Laboratory Medicine, Soonchunhyang University Seoul Hospital) ;
  • Kootae Park (Division of Nephrology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital) ;
  • Yon Hee Kim (Department of Pathology, Soonchunhyang University Seoul Hospital) ;
  • Soon Hyo Kwon (Division of Nephrology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital) ;
  • Jeong Won Shin (Department of Laboratory Medicine, Soonchunhyang University Seoul Hospital) ;
  • So Young Jin (Department of Pathology, Soonchunhyang University Seoul Hospital) ;
  • Jin Seok Jeon (Division of Nephrology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital)
  • Received : 2025.03.26
  • Accepted : 2025.07.07
  • Published : 2025.09.01
Download PDF
⟨ Previous Next ⟩

Abstract

Keywords

Acknowledgement

This study was supported by the Soonchunhyang University Research Fund.

References

  1. Tait BD, Süsal C, Gebel HM, Nickerson PW, Zachary AA, Claas FH, et al. Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation. Transplantation 2013;95:19–47. https://doi.org/10.1097/TP.0b013e31827a19cc
  2. Lee H, Lee H, Eum SH, Ko EJ, Min JW, Oh EJ, et al. Impact of low-level donor-specific anti-HLA antibody on posttranplant clinical outcomes in kidney transplant recipients. Ann Lab Med 2023;43:364–74. https://doi.org/10.3343/alm.2023.43.4.364
  3. Lee H, Lee S, Jeon JS, Kwon SH, Noh H, Han DC, et al. Thymoglobulin versus basiliximab induction therapy in low-risk kidney transplant recipients: a single-center experience. Transplant Proc 2018;50:1285–8. https://doi.org/10.1016/j.transproceed.2018.02.088
  4. Loupy A, Haas M, Solez K, Racusen L, Glotz D, Seron D, et al. The Banff 2015 kidney meeting report: Current challenges in rejection classification and prospects for adopting molecular pathology. Am J Transplant 2017;17:28–41. https://doi.org/10.1111/ajt.14107
  5. Muñoz-Herrera CM, Gutiérrez-Bautista JF, López-Nevot M. Clinical case: patient with mixed graft rejection four days after kidney transplantation developed specific antibodies against donor Bw4 specificities. Antibodies (Basel) 2021;10:28. https://doi.org/10.3390/antib10030028
  6. Persaud SP, Duffy B, Phelan DL, Mohanakumar T, Delos Santos R, Gaut JP, et al. Accelerated humoral renal allograft rejection due to HLA-C14 mediated allosensitization to HLA-Bw6. Hum Immunol 2017;78:692-8. https://doi.org/10.1016/j.humimm.2017.09.004
  7. Leffell MS, Kraus E, Racusen LC, Ratner LE, Charney D, Zachary AA. Effect of Bw4 and Bw6 epitope mismatches on antibody production, acute and chronic rejection, and graft survival in renal allografts. Transplantation 2001;72:433–7. https://doi.org/10.1097/00007890-200108150-00013
  8. Tang MS, Wang M, Chang SH, Alhamad T, Liu C. Association of Bw4/Bw6 mismatch across class I HLA loci with renal graft outcomes in first time transplants. Hum Immunol 2021;82:767–74. https://doi.org/10.1016/j.humimm.2021.07.008