Journal of Integrative Natural Science (통합자연과학논문집)

The Basic Science Institute Chosun University (조선대학교 기초과학연구원)
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Current Research on Infertility Treatment Using Stem Cell

줄기세포를 이용한 불임치료제 개발연구의 현황

  • Chaeyeon Kang (Department of Biomedical Science, Sunchon National University) ;
  • Ingyu Park (Department of Biomedical Science, Sunchon National University) ;
  • Byeonghyeon Bak (Department of Biomedical Science, Sunchon National University) ;
  • Haesu Park (Department of Biomedical Science, Sunchon National University) ;
  • Seoin Choi (Department of Biomedical Science, Sunchon National University) ;
  • Hang-soo Park (Department of Biomedical Science, Sunchon National University)
  • 강채연 (순천대학교 의생명과학과) ;
  • 박인규 (순천대학교 의생명과학과) ;
  • 박병현 (순천대학교 의생명과학과) ;
  • 박해수 (순천대학교 의생명과학과) ;
  • 최서인 (순천대학교 의생명과학과) ;
  • 박항수 (순천대학교 의생명과학과)
  • Received : 2025.05.16
  • Accepted : 2025.06.10
  • Published : 2025.06.30
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Abstract

The female infertility condition can be induced by various factors. Not only due to the cellular senescence of reproductive system, but also reproductive disorders can suppress the ovary activity. Unfortunately, many female reproductive disorders do not have effective treatment options or not effective to the underlying cause of this condition. To overcome those limitations in current treatment options, many researchers trying to find novel treatment strategies using stem cells. Mesenchymal stem cells are promising source based on their regenerative potential. In this study, we summarized recent published studies and introduce many experimental and pre-clinical data showing the therapeutic effect of stem cells in female reproductive disorder such as primary ovarian insufficiency(POI), polycystic ovary syndrome(PCOS), endometriosis. In addition, we also present the potential of stem cells for anti-ovarian aging treatment through published literature. We also introduce specialized cell culture conditions to generate improved stem cells, which have enhanced therapeutic potential for future clinical applications. Through this review study, we suggest stem cell-based therapy as a novel and fundamental treatment option for various female reproductive disorders to restore fertility in patients.

Keywords

Acknowledgement

본 연구는 국립순천대학교 2024학년도 대학자체지원사업 신진연구자지원사업의 지원을 받아 수행되었음.

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