Journal of Integrative Natural Science (통합자연과학논문집)

The Basic Science Institute Chosun University (조선대학교 기초과학연구원)
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Biological Age Variation Using the Epigenome in Parkinson's Disease Patients

파킨슨병 환자의 후성유전체를 이용한 생물학적 나이 변화

  • Jeong Hyeon Shim (Department of Biological Science, Department of Integrative Biological Science, BK21 FOUR Education Research Group for Age-Associated Disorder Control Technology, The Basic Science Institute of Chosun University, College of Natural Science, Chosun University) ;
  • Gwang-Won Cho (Department of Biological Science, Department of Integrative Biological Science, BK21 FOUR Education Research Group for Age-Associated Disorder Control Technology, The Basic Science Institute of Chosun University, College of Natural Science, Chosun University)
  • 심정현 (조선대학교 생명과학과) ;
  • 조광원 (조선대학교 생명과학과)
  • Received : 2024.12.31
  • Accepted : 2025.02.20
  • Published : 2025.06.30
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Abstract

Changes in DNA methylation patterns in human genes can not only impair gene activation but also contributes to epigenetic age. To measure these changes machine learning models are used which measures the degree of changes in DNA methylation pattern. Parkinson's disease is the second most common neurodegenerative disease which affects motor function. Even though it may develop before the age of 50 due to genetic factors, the gene that causes Parkinson's disease is linked to aging, so the incidence increases with age, and most people get affected by Parkinson's disease are over the age of 50. It is a geriatric disease that occurs in older aged people. Changes in DNA methylation patterns have been observed in patients with Parkinson's disease. Therefore, the epigenetic age of patients with Parkinson's disease was measured using Epi clock, which is one of the epigenetic clock models which was trained using 6761 CpG probes from pan tissue. Additionally, the acceleration of age was measured and changes in DNA methylation patterns were confirmed. Through this, it was confirmed that although the epigenetic age of Parkinson's disease patients accelerates, the difference is small which is approximately 1 to 5 years. Even though Hypo methylation of CpG probes increased, it was to a small extent.

Keywords

Acknowledgement

이 논문은 2024년도 정부(교육부)의 재원으로 한국연구재단의 G-램프(LAMP) 사업 지원을 받아 수행된 연구임(No. RS-2023-00285353).

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