Animal Bioscience

  • 제38권8호
  • /
  • Pages.1557-1569
  • /
  • 2025
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  • 2765-0189(pISSN)
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  • 2765-0235(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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Common factors and nutrients affecting intestinal villus height-A review

  • Jialu Wang (Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University) ;
  • Yuying Wu (Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences) ;
  • Tiantian Zhou (Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences) ;
  • Yingying Feng (Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences) ;
  • Liu-an Li (Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University)
  • 투고 : 2025.01.01
  • 심사 : 2025.03.16
  • 발행 : 2025.08.01
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⟨ 이전 논문 다음 논문 ⟩

초록

The villus of the small intestine plays an essential role in the digestion and absorption of nutrients. They mix chyme with digestive secretions and absorb nutrients by assisting in food agitation and adherence in the intestinal lumen. The height of villi is a critical indicator of the effective absorptive area of the small intestine, which will be greatly reduced if the villi are shortened. Many factors influence the height of intestinal villi, including age, diet, disease, and environmental conditions. This review summarizes the common factors affecting intestinal villus height to provide theoretical guidelines for enhancing intestinal health.

키워드

과제정보

This work was supported by National Natural Science Foundation of China (General Program, 32272905) and the Key Program for International S&T Cooperation Projects of Jiangxi, China (20232BBH80014).

참고문헌

  1. Chang EB, Martinez-Guryn K. Small intestinal microbiota: the neglected stepchild needed for fat digestion and absorption. Gut Microbes 2019;10:235-40. https://doi.org/10.1080/19490976.2018.1502539
  2. Wang HY, Chen S, Xue RY, et al. Arsenic ingested early in life is more readily absorbed: mechanistic insights from gut microbiota, gut metabolites, and intestinal morphology and functions. Environ Sci Technol 2023;57:1017-27. https://doi.org/10.1021/acs.est.2c04584
  3. De Gregorio V, Imparato G, Urciuolo F, Netti PA. Micropatterned endogenous stroma equivalent induces polarized crypt-villus architecture of human small intestinal epithelium. Acta Biomater 2018;81:43-59. https://doi.org/10.1016/j.actbio.2018.09.061
  4. Macagno EO, Christensen J. Fluid mechanics of the duodenum. Annu Rev Fluid Mech 1980;12:139-58. https://doi.org/10.1146/annurev.fl.12.010180.001035
  5. Freddo AM, Shoffner SK, Shao Y, et al. Coordination of signaling and tissue mechanics during morphogenesis of murine intestinal villi: a role for mitotic cell rounding. Integr Biol 2016;8:918-28. https://doi.org/10.1039/c6ib00046k
  6. Kondrashina A, Arranz E, Cilla A, et al. Coupling in vitro food digestion with in vitro epithelial absorption; recommendations for biocompatibility. Crit Rev Food Sci Nutr 2024;64:9618-36. https://doi.org/10.1080/10408398.2023.2214628
  7. Anthony A, Dhillon AP, Thrasivoulou C, Pounder RE, Wakefield AJ. Pre-ulcerative villous contraction and microvascular induced by indomethacin in the rat jejunum: a detailed morphological study. Aliment Pharmacol Ther 1995;9:605-13. https://doi.org/10.1111/j.1365-2036.1995.tb00429.x
  8. Oh S, Yoo YB. Epithelial-mesenchymal interactions for the development of intestinal villi. Dev Reprod 2019;23:305-11. https://doi.org/10.12717/DR.2019.23.4.305
  9. Segú H, Jalševac F, Pinent M, Ardévol A, Terra X, Blay MT. Intestinal morphometric changes induced by a Westernstyle diet in Wistar rats and GSPE counter-regulatory effect. Nutrients 2022;14:2608. https://doi.org/10.3390/nu14132608
  10. Stojanović O, Altirriba J, Rigo D, et al. Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα. Nat Commun 2021;12:7031. https://doi.org/10.1038/s41467-021-27133-7
  11. Amadi B, Besa E, Zyambo K, et al. Impaired barrier function and autoantibody generation in malnutrition enteropathy in Zambia. eBioMedicine 2017;22:191-9. https://doi.org/10.1016/j.ebiom.2017.07.017
  12. Santos A, Valdés C, Giráldez FJ, et al. Feed efficiency and the liver proteome of fattening lambs are modified by feed restriction during the suckling period. Animal 2018;12:1838-46. https://doi.org/10.1017/S1751731118000046
  13. Zhao X, Fu HY, Qiu SN, et al. Effects of early protein restriction on the growth performance and gut development of pigs fed diets with or without antibiotic. Animal 2020;14:1392-401. https://doi.org/10.1017S1751731119002921 https://doi.org/10.1017S1751731119002921
  14. Amoah K, Dong X, Tan B, et al. Effects of three probiotic strains (Bacillus coagulans, B. licheniformis and Paenibacillus polymyxa) on growth, immune response, gut morphology and microbiota, and resistance against Vibrio harveyi of northern whitings, Sillago sihama Forsskál (1775). Anim Feed Sci Technol 2021;277:114958. https://doi.org/10.1016/j.anifeedsci.2021.114958
  15. Ayman U, Akter L, Islam R, et al. Dietary chitosan oligosaccharides improves health status in broilers for safe poultry meat production. Ann Agric Sci 2022;67:90-8. https://doi.org/10.1016/j.aoas.2022.05.003
  16. de Medeiros PHQS, Pinto DV, de Almeida JZ, et al. Modulation of intestinal immune and barrier functions by vitamin A: implications for current understanding of malnutrition and enteric infections in children. Nutrients 2018;10:1128. https://doi.org/10.3390/nu10091128
  17. Lounder DT, Khandelwal P, Dandoy CE, et al. Lower levels of vitamin A are associated with increased gastrointestinal graft-versus-host disease in children. Blood 2017;129:2801-7. https://doi.org/10.1182/blood-2017-02-765826
  18. Xiao X, Liang JR, Yang HM, Wan XL, Wang ZY. Vitamin A deficiency or critical excess has negative effects on the growth performance, slaughter performance, and meat quality of goslings. Anim Feed Sci Technol 2021;280:115064. https://doi.org/10.1016/j.anifeedsci.2021.115064
  19. Zhao J, Liu Y, Sun Z, et al. Effects of different levels of carbohydrates on growth performance, hepatic and intestinal health, and intestinal microflora of juvenile pikeperch (Sander lucioperca). Aquac Nutr 2024;2024:8450154. https://doi.org/10.1155/2024/8450154
  20. Wu LX, Li QL, Luo Z, et al. Effects of dietary vitamin D3 and carbohydrate levels on growth performance, carbohydrate metabolism, and intestinal health of yellow catfish (Pelteobagrus fulvidraco). Aquaculture 2024;592:741136. https://doi.org/10.1016/j.aquaculture.2024.741136
  21. Incharoen T, Yamauchi K, Erikawa T, Gotoh H. Histology of intestinal villi and epithelial cells in chickens fed low-crude protein or low-crude fat diets. Ital J Anim Sci 2010;9:e82. https://doi.org/10.4081/ijas.2010.e82
  22. Santos MJB, Ludke MCMM, Silva LM, et al. Complexed amino acid minerals vs. bis-glycinate chelated minerals: impact on the performance of old laying hens. Anim Nutr 2024;16:395-408. https://doi.org/10.1016/j.aninu.2023.11.006
  23. Rostamkhani AR, Shahir MH, Lemme A, Anarkooli IJ, Abdi Z. Impact of early feeding of highly available carbohydrate source on subsequent growth performance, carcass traits, blood biochemical parameters, and intestinal morphology of broilers. J Appl Poult Res 2024;33:100399. https://doi.org/10.1016/j.japr.2023.100399
  24. Yang L, Luo H, Tan D, et al. A recent update on the use of Chinese medicine in the treatment of inflammatory bowel disease. Phytomedicine 2021;92:153709. https://doi.org/10.1016/j.phymed.2021.153709
  25. Cao M, Che L, Wang J, et al. Effects of maternal over- and undernutrition on intestinal morphology, enzyme activity, and gene expression of nutrient transporters in newborn and weaned pigs. Nutrition 2014;30:1442-7. https://doi.org/10.1016/j.nut.2014.04.016
  26. Taylor SR, Ramsamooj S, Liang RJ, et al. Dietary fructose improves intestinal cell survival and nutrient absorption. Nature 2021;597:263-7. https://doi.org/10.1038/s41586-021-03827-2
  27. Berrocoso JD, Kida R, Singh AK, Kim YS, Jha R. Effect of in ovo injection of raffinose on growth performance and gut health parameters of broiler chicken. Poult Sci 2017;96:1573-80. https://doi.org/10.3382/ps/pew430
  28. Osho SO, Adeola O. Chitosan oligosaccharide supplementation alleviates stress stimulated by in-feed dexamethasone in broiler chickens. Poult Sci 2020;99:2061-7. https://doi.org/10.1016/j.psj.2019.11.047
  29. Song J, Li Q, Li P, et al. The effects of inulin on the mucosal morphology and immune status of specific pathogen-free chickens. Poult Sci 2018;97:3938-46. https://doi.org/10.3382/ps/pey260
  30. Liao L, Li J, Li J, Huang Y, Wu Y. Effects of Astragalus polysaccharides on intestinal morphology and intestinal immune cells of Muscovy ducklings infected with Muscovy duck reovirus. Poult Sci 2021;100:64-72. https://doi.org/10.1016/j.psj.2020.10.021
  31. Feng Y, Wu Y, Wang J, et al. Enteromorpha prolifera polysaccharide-Fe (III) complex promotes intestinal development as a new iron supplement. Sci China Life Sci 2025;68:219-31. https://doi.org/10.1007/s11427-023-2562-9
  32. Guo G, Chen J, Peng S, et al. Effects of fucoidan on small intestinal tissue morphology, digestive enzyme activity and antioxidant indices of weaned lambs. Chin J Anim Nutr 2022;34:5206-18. https://10.3969/j.issn.1006-267x.2022.08.043
  33. Yang Z. Effect of Atractylodes macrocephala polysaccharides on growth performance, serum biochemical indicators and intestinal morphology of broilers. Feed Res 2023;46:46-50. https://doi.org/10.13557/j.cnki.issn1002-2813.2023.12.010
  34. Zhao W, Cao M, Jin Y, Zhang J, Miao Z. Effect of Chinese yam polysaccharide on immune performance and intestinal morphology of weaned piglets. China Feed 2021;11:37-41. https://doi.org/10.15906/j.cnki.cn11-2975/s.20211107
  35. Wang X Wang W, Wang L, et al. Lentinan modulates intestinal microbiota and enhances barrier integrity in a piglet model challenged with lipopolysaccharide. Food Funct 2019;10:479-89. https://doi.org/10.1039/C8Fo02438C
  36. Wang Y, Chen B, Cao J, et al. Effects of mulberry leaf flavonoids on intestinal mucosal morphology and intestinal flora of Litopenaeus vannamei. Chin J Anim Nutr 2020;32:1817-25.
  37. Liu D, Dong S, Chen X, Zhimin J. Research progress in biological function and application of Andrographispaniculatain animal production. Feed Res 2022;45:148-52. https://doi.org/10.13557/j.cnki.issn1002-2813.2022.22.032
  38. Liu A, Gong Z, Lin L, et al. Effects of l-theanine on glutamine metabolism in enterotoxigenic Escherichia coli (E44813)-stressed and non-stressed rats. J Funct Foods 2020;64:103670. https://doi.org/10.1016/j.jff.2019.103670
  39. Hu F, Liu Y, Liang X, Yang H, Xu H, Han F. To investigate the effect of oregano oil on ulcerative colitis mice based on intestinal flora and inflammatory factors. Chin Tradit Pat Med 2023;4:1294-300.
  40. Zhang LY, Peng QY, Liu YR, et al. Effects of oregano essential oil as an antibiotic growth promoter alternative on growth performance, antioxidant status, and intestinal health of broilers. Poult Sci 2021;100:101163. https://doi.org/10.1016/j.psj.2021.101163
  41. Wang L, Zhang Y, Liu L, Huang F, Dong B. Effects of threelayer encapsulated tea tree oil on growth performance, antioxidant capacity, and intestinal microbiota of weaned pigs. Front Vet Sci 2021;8:789225. https://doi.org/10.3389/fvets.2021.789225
  42. Liu Y, Song M, Che TM, et al. Dietary plant extracts alleviate diarrhea and alter immune responses of weaned pigs experimentally infected with a pathogenic Escherichia coli. J Anim Sci 2013;91:5294-306. https://doi.org/10.2527/jas.2012-6194
  43. Song Z, Zhao GY, Dong Y, et al. Effect of compound plant essential oils on structure of intestinal mucosa and antioxidant capacity of weaned piglets challenged with lipopolysaccharide. China Anim Husb Vet Med 2019;46:684-9. https://doi.org/10.16431/j.cnki.1671-7236.2019.03.006
  44. Wang J, Yang X, Qi Q, et al. Effects of curcumin on growth performance, meat quality and intestinal health of Cherry Valley ducks. Anim Husb Vet Med 2023;55:29-37.
  45. Deng QF, Gao F. Application of plant tannin in livestock and poultry breeding. China Feed 2015:38-41. https://doi.org/10.15906/j.cnki.cn11-2975/s.20151310
  46. Deng W, Zhang SC, Cai RB, Ren SC, Zhou XJ. Effects of chestnut tannins on the performance, intestinal morphology and permeability, and antioxidant status in weaned piglets. China Feed 2018;597:44-8. https://doi.org/10.15906/j.cnki.cn11-2975/s.20180108
  47. Wang L, Song S, Cao Y, et al. Effects of Gelsemium elegans alkaloids on growth performance in weaned piglets. Chin J Vet Med 2023;59:136-43.
  48. Chen J, Kang B, Zeng J, et al. Effects of dietary sanguinarine on growth performance, intestinal mucosal morphology and immune function of small intestinal mucosa of weaned piglets. Chin J Anim Nutr 2018;30:1845-53.
  49. Song Z, Xie K, Zhang Y, Xie Q, He X, Zhang H. Effects of dietary ginsenoside Rg1 supplementation on growth performance, gut health, and serum immunity in broiler chickens. Front Nutr 2021;8:705279. https://doi.org/10.3389/fnut.2021.705279
  50. Wang M, Yuan X, He J. Saccharicterpenin role and mechanism of animals. Swine Prod 2022:28-30. https://doi.org/10.13257/j.cnki.21-1104/s.2022.03.013
  51. Hao T, Zhang L, Li B, et al. Effects of saccharicterpenin-supplemented diets on body composition, activity of intestinal enzymes, blood lipid and intestinal histology of juvenile turbot (Scophthalmus maximus). J Shanghai Ocean Univ 2015;24:391-402.
  52. Huang P, Zhao SS, Zhang XW, Zhang TT, Xiao CB. Effects of dietary saccharicterpenin on mucosal structure of small intestine in Gushi chickens. Chin J Anim Nutr 2011;23:2016-23. https://10.3969/j.issn.1006-267x.2011.11.024
  53. Qi M, Li T, Zhang K, et al. Effects of essential oil and compound organic acids on growth performance, serum biochemical indices and intestinal health of broilers. Chin J Anim Nutr 2022;34:5652-66. https://doi.org/10.3969/j.issn.1006-267x.2022.09.021
  54. Zheng WC, Xu J, Yang L. Effects of probiotics and organic acids on growth performance, intestinal morphology and immune indexes of weaned piglets. Guangdong Feed 2016;25:25-8.
  55. Xu YJ, Ning SQ, Su SL, et al. The fundamental role of dietary amino acids in maintaining or improving intestinal health in weaned piglets. Swine Ind Sci 2022;39:80-4.
  56. Kahindi R, Regassa A, Htoo J, Nyachoti M. Optimal sulfur amino acid to lysine ratio for post weaning piglets reared under clean or unclean sanitary conditions. Anim Nutr 2017;3:380-5. https://doi.org/10.1016/j.aninu.2017.08.004
  57. Awad WA, Ghareeb K, Abdel-Raheem S, Böhm J. Effects of dietary inclusion of probiotic and synbiotic on growth performance, organ weights, and intestinal histomorphology of broiler chickens. Poult Sci 2009;88:49-56. https://doi.org/10.3382/ps.2008-00244
  58. Tůmová E, Volek Z, Chodová D, et al. The effect of 1-week feed restriction on performance, digestibility of nutrients and digestive system development in the growing rabbit. Animal 2016;10:1-9. https://doi.org/10.1017/S1751731115001810
  59. Wang K, Hu C, Tang W, et al. The enhancement of intestinal immunity in offspring piglets by maternal probiotic or synbiotic supplementation is associated with the alteration of gut microbiota. Front Nutr 2021;8:686053. https://doi.org/10.3389/fnut.2021.686053
  60. Guo YJ, Wang ZY, Wang YS, et al. Impact of drinking water supplemented 2-hydroxy-4-methylthiobutyric acid in combination with acidifier on performance, intestinal development, and microflora in broilers. Poult Sci 2022;101:101661. https://doi.org/10.1016/j.psj.2021.101661
  61. Elhassan MMO, Ali AM, Blanch A, Kehlet AB, Madekurozwa MC. Morphological responses of the small intestine of broiler chicks to dietary supplementation with a probiotic, acidifiers, and their combination. J Appl Poult Res 2019;28:108-17. https://doi.org/10.3382/japr/pfy042
  62. Tiwari UP, Chen H, Kim SW, Jha R. Supplemental effect of xylanase and mannanase on nutrient digestibility and gut health of nursery pigs studied using both in vivo and in vitro models. Anim Feed Sci Technol 2018;245:77-90. https://doi.org/10.1016/j.anifeedsci.2018.07.002
  63. Pekel AY, Horn NL, Adeola O. The efficacy of dietary xylanase and phytase in broiler chickens fed expeller-extracted camelina meal. Poult Sci 2017;96:98-107. https://doi.org/10.3382/ps/pew183
  64. Wu Y, Cheng B, Ji L, et al. Dietary lysozyme improves growth performance and intestinal barrier function of weaned piglets. Anim Nutr 2023;14:249-58. https://doi.org/10.1016/j.aninu.2023.06.003
  65. Li H, Ran T, He Z, Yan Q, Tang S, Tan Z. Postnatal developmental changes of the small intestinal villus height, crypt depth and hexose transporter mRNA expression in supplemental feeding and grazing goats. Small Rumin Res 2016;141:106-12. https://doi.org/10.1016/j.smallrumres.2016.07.012
  66. Wang JX, Li P, Zhang XT, Ye LX. Developmental morphology study on the stomach of African ostrich chicks. Poult Sci 2017;96:2006-12. https://doi.org/10.3382/ps/pew504
  67. Schaefer CM, Corsiglia CM, Mireles A Jr, Koutsos EA. Turkey breeder hen age affects growth and systemic and intestinal inflammatory responses in female poults examined at different ages posthatch. Poult Sci 2006;85:1755-63. https://doi.org/10.1093/ps/85.10.1755
  68. Refaey MM, Li D, Tian X, et al. High stocking density alters growth performance, blood biochemistry, intestinal histology, and muscle quality of channel catfish Ictalurus punctatus. Aquaculture 2018;492:73-81. https://doi.org/10.1016/j.aquaculture.2018.04.003
  69. Applegate TJ, Karcher DM, Lilburn MS. Comparative development of the small intestine in the turkey poult and Pekin duckling. Poult Sci 2005;84:426-31. https://doi.org/10.1093/ps/84.3.426
  70. Luo QT, Ye YC, Guo WM, et al. Senolytic treatment improve small intestine regeneration in aging. Aging Dis 2024;15:1499-507. https://doi.org/10.14336/AD.2023.0920
  71. Martel J, Chang SH, Ko YF, Hwang TL, Young JD, Ojcius DM. Gut barrier disruption and chronic disease. Trends Endocrinol Metab 2022;33:247-65. https://doi.org/10.1016/j.tem.2022.01.002
  72. Hohman LS, Osborne LC. A gut-centric view of aging: do intestinal epithelial cells contribute to age-associated microbiota changes, inflammaging, and immunosenescence? Aging Cell 2022;21:e13700. https://doi.org/10.1111/acel.13700
  73. Zhang J, Jiang Z, Chen C, et al. Age-associated decline in RAB-10 efficacy impairs intestinal barrier integrity. Nat Aging 2023;3:1107-27. https://doi.org/10.1038/s43587-023-00475-1
  74. Funk MC, Gleixner JG, Heigwer F, et al. Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice. Dev Cell 2023;58:2914-29.E7. https://doi.org/10.1016/j.devcel.2023.11.013
  75. Ru M, Wang W, Zhai Z, et al. Nicotinamide mononucleotide supplementation protects the intestinal function in aging mice and D-galactose induced senescent cells. Food Funct 2022;13:7507-19. https://doi.org/10.1039/D2FO00525E
  76. Gautam H, Ayalew LE, Shaik NA, et al. Exploring the predictive power of jejunal microbiome composition in clinical and subclinical necrotic enteritis caused by Clostridium perfringens: insights from a broiler chicken model. J Transl Med 2024;22:80. https://doi.org/10.1186/s12967-023-04728-w
  77. Xu H, Fu J, Luo Y, et al. Effects of tannic acid on the immunity and intestinal health of broiler chickens with necrotic enteritis infection. J Anim Sci Biotechnol 2023;14:72. https://doi.org/10.1186/s40104-023-00867-8
  78. Epple HJ, Friebel J, Moos V, et al. Architectural and functional alterations of the small intestinal mucosa in classical Whipple's disease. Mucosal Immunol 2017;10:1542-52. https://doi.org/10.1038/mi.2017.6
  79. Koehler P, Wieser H, Scherf KA. Celiac disease. In: Kırtıl E, Kılercıoglu M, Öztop HM, editors. Reference module in food science. Elsevier; 2016.
  80. Sancho R, Nateri AS, de Vinuesa AG, et al. JNK signalling modulates intestinal homeostasis and tumourigenesis in mice. EMBO J 2009;28:1843-54. https://doi.org/10.1038/emboj.2009.153
  81. Giammanco A, Blanc V, Montenegro G, et al. Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development. Cancer Res 2014;74:5322-35. https://doi.org/10.1158/0008-5472.CAN-14-0726
  82. Piovezana Bossolani GD, Silva BT, Colombo Martins Perles JV, et al. Rheumatoid arthritis induces enteric neurodegeneration and jejunal inflammation, and quercetin promotes neuroprotective and anti-inflammatory actions. Life Sci 2019;238:116956. https://doi.org/10.1016/j.lfs.2019.116956
  83. Mayer EA, Nance K, Chen S. The gut–brain axis. Annu Rev Med 2022;73:439-53. https://doi.org/10.1146/annurev-med042320-014032
  84. Hang CH, Shi JX, Sun BW, Li JS. Apoptosis and functional changes of dipeptide transporter (PepT1) in the rat small intestine after traumatic brain injury. J Surg Res 2007;137:53-60. https://doi.org/10.1016/j.jss.2006.06.026
  85. Chen YM, Helm ET, Groeltz-Thrush JM, Gabler NK, Burrough ER. Epithelial-mesenchymal transition of absorptive enterocytes and depletion of Peyer's patch M cells after PEDV infection. Virology 2021;552:43-51. https://doi.org/10.1016/j.virol.2020.08.018
  86. Madson DM, Magstadt DR, Arruda PHE, et al. Pathogenesis of porcine epidemic diarrhea virus isolate (US/Iowa/18984/2013) in 3-week-old weaned pigs. Vet Microbiol 2014;174:60-8. https://doi.org/10.1016/j.vetmic.2014.09.002
  87. Guo M, Saif LJ. IV, 3. Pathogenesis of enteric calicivirus infections. In: Desselberger U, Gray J, editors. Perspectives in medical virology. Elsevier; 2003. pp. 489-503. https://doi.org/10.1016/S0168-7069(03)09029-3
  88. Wang D, Zhou X, She R, et al. Impaired intestinal mucosal immunity in specific-pathogen-free chickens after infection with very virulent infectious bursal disease virus. Poult Sci 2009;88:1623-8. https://doi.org/10.3382/ps.2009-00124
  89. Feng GD, He J, Ao X, Chen DW. Effects of maize naturally contaminated with aflatoxin B1 on growth performance, intestinal morphology, and digestive physiology in ducks. Poult Sci 2017;96:1948-55. https://doi.org/10.3382/ps/pew420
  90. Wang A, Hogan NS. Performance effects of feed-borne Fusarium mycotoxins on broiler chickens: influences of timing and duration of exposure. Anim Nutr 2019;5:32-40. https://doi.org/10.1016/j.aninu.2018.08.001
  91. Teng PY, Yadav S, Dos Santos TS, Fuller AL, Kim WK. 2-Nitro-1-propanol improved nutrient digestibility and oocyst shedding but not growth performance of Eimeria-challenged broilers. Poult Sci 2020;99:4314-22. https://doi.org/10.1016/j.psj.2020.05.038
  92. Assis RCL, Luns FD, Beletti ME, et al. Histomorphometry and macroscopic intestinal lesions in broilers infected with Eimeria acervulina. Vet Parasitol 2010;168:185-9. https://doi.org/10.1016/j.vetpar.2009.11.017
  93. Martins C, Teixeira C, Ribeiro S, et al. Seronegative intestinal villous atrophy: a diagnostic challenge. Case Rep Gastrointest Med 2016;2016:6392028. https://doi.org/10.1155/2016/6392028
  94. Huang L, Chiang Chiau JS, Cheng ML, et al. SCID/NOD mice model for 5-FU induced intestinal mucositis: safety and effects of probiotics as therapy. Pediatr Neonatol 2019;60:252-60. https://doi.org/10.1016/j.pedneo.2018.07.007
  95. Lucas S. The pharmacology of indomethacin. Headache 2016;56:436-46. https://doi.org/10.1111/head.12769
  96. Yi D, Liu W, Hou Y, et al. Establishment of a porcine model of indomethacin-induced intestinal injury. Front Biosci (Landmark Ed) 2018;23:2166-76. https://doi.org/10.2741/4697
  97. Tian J, Washizawa N, Gu LH, et al. Local glutathione redox status does not regulate ileal mucosal growth after massive small bowel resection in rats. J Nutr 2007;137:320-5. https://doi.org/10.1093/jn/137.2.320
  98. Stehr W, Bernal NP, Bernabe KQ, Erwin CR, Warner BW. Absent STAT-1 expression perturbs adaptation and apoptosis after massive intestinal resection. J Pediatr Surg 2006;41:713-8. https://doi.org/10.1016/j.jpedsurg.2005.12.015
  99. Toth S, Jonecova Z, Maretta M, et al. The effect of betanin parenteral pretreatment on jejunal and pulmonary tissue histological architecture and inflammatory response after jejunal ischemia-reperfusion injury. Exp Mol Pathol 2019;110:104292. https://doi.org/10.1016/j.yexmp.2019.104292
  100. Xie D, Li J, Wang ZX, et al. Effects of monochromatic light on mucosal mechanical and immunological barriers in the small intestine of broilers. Poult Sci 2011;90:2697-704. https://doi.org/10.3382/ps.2011-01416
  101. Barri A, Honaker CF, Sottosanti JR, Hulet RM, McElroy AP. Effect of incubation temperature on nutrient transporters and small intestine morphology of broiler chickens. Poult Sci 2011;90:118-25. https://doi.org/10.3382/ps.2010-00908
  102. Liu ZL, Chen Y, Xue JJ, et al. Effects of ambient temperature on the growth performance, fat deposition, and intestinal morphology of geese from 28 to 49 days of age. Poult Sci 2022;101:101814. https://doi.org/10.1016/j.psj.2022.101814
  103. Gogoi S, Kolluri G, Tyagi JS, Marappan G, Manickam K, Narayan R. Impact of heat stress on broilers with varying body weights: elucidating their interactive role through physiological signatures. J Therm Biol 2021;97:102840. https://doi.org/10.1016/j.jtherbio.2021.102840
  104. Palander PA, Heinonen M, Simpura I, Edwards SA, Valros AE. Jejunal morphology and blood metabolites in tail biting, victim and control pigs. Animal 2013;7:1523-31. https://doi.org/10.1017/S1751731113000669
  105. He Y, Liu N, Ji Y, Tso P, Wu Z. Weaning stress in piglets alters the expression of intestinal proteins involved in fat absorption. J Nutr 2022;152:2387-95. https://doi.org/10.1093/jn/nxac177