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Comparing the Effect of Oil Massage on Phototherapy Efficacy in Term Neonates with Hyperbilirubinemia: A Randomized Controlled Trial

  • Dinesh Kumar (Department of Pediatrics, Uttar Pradesh University of Medical Sciences) ;
  • Durgesh Kumar (Department of Pediatrics, Uttar Pradesh University of Medical Sciences) ;
  • Pankaj Kumar Arya (Department of Pediatrics, GSVM Medical College) ;
  • Muniba Alim (Department of Pediatrics, Uttar Pradesh University of Medical Sciences) ;
  • Indra Kumar Sharma (Department of Pediatrics, Uttar Pradesh University of Medical Sciences) ;
  • Rajesh Kumar Yadav (Department of Pediatrics, Uttar Pradesh University of Medical Sciences) ;
  • Nishant Sharma (Department of Pediatrics, Uttar Pradesh University of Medical Sciences)
  • Received : 2024.08.02
  • Accepted : 2024.12.16
  • Published : 2025.03.15

Abstract

Purpose: This study aimed to evaluate the efficacy of oil massage as an adjunct therapy for neonatal jaundice during phototherapy. Methods: A total of 160 neonates with unconjugated hyperbilirubinemia were enrolled and randomly allocated into two study groups using a computer-generated random number table. Group 1 (Intervention Group) consisted of 84 patients who received both phototherapy and massage therapy, while Group 2 (Control Group) consisted of 76 patients who received only phototherapy. The intervention group underwent massage therapy three times daily for 20 minutes over two consecutive days. Transcutaneous bilirubin levels were measured every eight hours. Additionally, the total duration of phototherapy and the 24-hour stool and urine output frequency were recorded in both groups. Results: There were no significant differences in the demographic characteristics between the two groups. However, stool frequency and urine output were significantly higher in the intervention group. The average duration of phototherapy was 19.4±4.17 hours in the intervention group compared to 28.4±6.58 hours in the control group (p<0.001). The rate of Transcutaneous bilirubin reduction was significantly higher in the intervention group during the first 24 hours. A rebound increase in bilirubin levels was observed at 40 and 48 hours in both groups after phototherapy was discontinued. Conclusion: Phototherapy combined with massage significantly reduced total bilirubin levels in newborns with neonatal hyperbilirubinemia, making it a valuable adjunct treatment for the rapid reduction of bilirubin in neonates.

Keywords

References

  1. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. American Academy of Paediatrics. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 2004;114:297-316. https://doi.org/10.1542/peds.114.1.297
  2. Maisels MJ, McDonagh AF. Phototherapy for neonatal jaundice. N Engl J Med 2008;358:2524-525.  https://doi.org/10.1056/NEJMc080672
  3. Kaplan M, Bromiker R, Hammerman C. Severe neonatal hyperbilirubinemia and kernicterus: are these still problems in the third millennium? Neonatology 2011;100:354-62. https://doi.org/10.1159/000330055
  4. Smith SL, Lux R, Haley S, Slater H, Beachy J, Moyer-Mileur LJ. The effect of massage on heart rate variability in preterm infants. J Perinatol 2013;33:59-64. https://doi.org/10.1038/jp.2012.47
  5. Kulkarni A, Kaushik JS, Gupta P, Sharma H, Agrawal RK. Massage and touch therapy in neonates: the current evidence. Indian Pediatr 2010;47:771-6. https://doi.org/10.1007/s13312-010-0114-2
  6. Field T, Diego M, Hernandez-Reif M. Preterm infant massage therapy research: a review. Infant Behav Dev 2010;33:115-24. https://doi.org/10.1016/j.infbeh.2009.12.004
  7. Moyer-Mileur LJ, Haley S, Slater H, Beachy J, Smith SL. Massage improves growth quality by decreasing body fat deposition in male preterm infants. J Pediatr 2013;162:490-5. https://doi.org/10.1016/j.jpeds.2012.08.033
  8. Jane SW, Chen SL, Wilkie DJ, Lin YC, Foreman SW, Beaton RD, et al. Effects of massage on pain, mood status, relaxation, and sleep in Taiwanese patients with metastatic bone pain: a randomized clinical trial. Pain 2011;152:2432-42. https://doi.org/10.1016/j.pain.2011.06.021
  9. Hernandez-Reif M, Diego M, Field T. Preterm infants show reduced stress behaviors and activity after 5 days of massage therapy. Infant Behav 2007;30:557-61. https://doi.org/10.1016/j.infbeh.2007.04.002
  10. Chen J, Sadakata M, Ishida M, Sekizuka N, Sayama M. Baby massage ameliorates neonatal jaundice in full-term newborn infants. Tohoku J Exp Med 2011;223:97-102. https://doi.org/10.1620/tjem.223.97
  11. Moghadam MB, Moghadam KB, Kianmehr M, Jomezadeh A, Davoudi F. Effects of massage on weight gain and jaundice in term neonates with hyperbilirubinemia. J Isfahan Med 2012;30:1-8.
  12. Rylance S, Yan J, Molyneux E. Can transcutaneous bilirubinometry safely guide phototherapy treatment of neonatal jaundice in Malawi? Paediatr Int Child Health 2014;34:101-7. https://doi.org/10.1179/2046905513Y.0000000050
  13. Chimhini GL, Chimhuya S, Chikwasha V. Evaluation of transcutaneous bilirubinometer use in Zimbabwean newborn babies. Matern Health Neonatol Perinatol 2018;4:1-7. https://doi.org/10.1186/s40748-017-0070-0
  14. Alsaedi SA. Transcutaneous bilirubin measurements can be used to measure bilirubin levels during phototherapy. Int J Pediatr 2018;2018:4856390. https://doi.org/10.1155/2018/4856390
  15. Ying Q, You X, You J, Wang J. The accuracy of transcutaneous bilirubin to identify hyperbilirubinemia in jaundiced neonates. J Matern Fetal Neonatal Med 2022;35:4318-25. https://doi.org/10.1080/14767058.2020.1849112
  16. Kumar D, Kumar D. A prospective comparison of serum and transcutaneous bilirubin in Indian neonates. J Pediatr Intensive Care 2020;11:100-4.
  17. Korkmaz G, Esenay FI. Effects of massage therapy on indirect hyperbilirubinemia in newborns who receive phototherapy. J Obstet Gynecol Neonatal Nurs 2020;49:91-100. https://doi.org/10.1016/j.jogn.2019.11.004
  18. Simpson R. Baby massage classes and the work of the International Association of Infant Massage. Complement Ther Nurs Midwifery 2001;7:25-33. https://doi.org/10.1054/ctnm.2000.0510
  19. Eghbalian F, Rafienezhad H, Farmal J. The lowering of bilirubin levels in patients with neonatal jaundice using massage therapy: A randomized, double-blind clinical trial. Infant Behav Dev 2017;49:31-6.  https://doi.org/10.1016/j.infbeh.2017.05.002
  20. Shahbazi M, Khazaei S, Moslehi S, Shahbazi F. Effect of massage therapy for the treatment of neonatal jaundice: a systematic review and dose-response meta-analysis. Int J Pediatr 2022;2022:9161074. https://doi.org/10.1155/2022/9161074
  21. Karbandi S, Lotfi M, Boskabadi H, Esmaily H. The effects of field massage technique on bilirubin level and the number of defecations in preterm infants. Evid Based Care J 2016;5:7-16.
  22. Dalili H, Sheikhi S, Shariat M, Haghnazarian E. Effects of baby massage on neonatal jaundice in healthy Iranian infants: A pilot study. Infant Behav Dev 2016;42:22-6. https://doi.org/10.1016/j.infbeh.2015.10.009
  23. Seyyedrasooli A, Valizadeh L, Hosseini MB, Jafarabadi MA, Mohammadzad M. Effect of vimala massage on physiological jaundice in infants: a randomized controlled trial. J Caring Sci 2014;3:165-73.
  24. Lin CH, Yang HC, Cheng CS, Yen CE. Effects of infant massage on jaundiced neonates undergoing phototherapy. Ital J Pediatr 2015;41:94. https://doi.org/10.1186/s13052-015-0202-y
  25. Diego MA, Field T, Hernandez-Reif M, Deeds O, Ascencio A, Begert G. Preterm infant massage elicits consistent increases in vagal activity and gastric motility that are associated with greater weight gain. Acta Paediatr 2007;96:1588-91. https://doi.org/10.1111/j.1651-2227.2007.00476.x
  26. Maheshwari A, Carlo W. Diseases of the digestive system. In: Kliegman RM, Stanton BM, Geme JS, eds. Nelson textbook of pediatrics. 21st ed. Elsevier Health Science, 2019:603-12.
  27. Nangia S, Paul VK, Deorari AK, Sreenivas V, Agarwal R, Chawla D. Topical oil application and transepidermal water loss in preterm very low birth weight infants—a randomized trial. J Trop Pediatr 2015;61:414-20. https://doi.org/10.1093/tropej/fmv049
  28. Jeong SJ, Park MK. Effects of infant massage therapy on transcutaneous bilirubin, feeding, and excretion in neonates with jaundice undergoing phototherapy. J Korean Soc Matern Child Health 2018;22:25-34. https://doi.org/10.21896/jksmch.2018.22.1.25