한국자기공명학회논문지 (Journal of the Korean Magnetic Resonance Society)

한국자기공명학회 (Korean Magnetic Resonance Society)
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Recent advances in biomolecular 19F-NMR: applications to transthyretin amyloidosis

  • Jin Hae Kim (Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST))
  • 투고 : 2025.03.19
  • 심사 : 2025.03.20
  • 발행 : 2025.03.20
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초록

Nuclear magnetic resonance (NMR) spectroscopy is a versatile tool for investigating various physicochemical properties of biomolecules. Among diverse applications of biomolecular NMR spectroscopy, 19F-based methodology has recently attracted much attention from researchers in protein science owing to its advantageous applicability to proteins of high molecular weights or heterogeneous structural states. In this mini-review, the recent application example of 19F NMR to transthyretin, a representative amyloidogenic protein, thus being an important yet challenging target for structural investigation, is summarized along with some perspectives for its future directions.

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과제정보

This research was supported by the National Research Foundation (NRF) funded by the Ministry of Science & ICT of Republic of Korea (RS-2025-00463074).

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