Acknowledgement
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) & funded by Korean government (MSIT) (No. 2022M3A9F3016364).
References
- Berglundh T, Armitage G, Araujo MG, Avila-Ortiz G, Blanco J, Camargo PM, et al. Peri-implant diseases and conditions: consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol 2018;45 Suppl 1:S286-91.
- Derks J, Schaller D, Hakansson J, Wennstrom JL, Tomasi C, Berglundh T. Effectiveness of implant therapy analyzed in a swedish population: prevalence of peri-implantitis. J Dent Res 2016;95:43-9. https://doi.org/10.1177/0022034515608832
- Derks J, Schaller D, Hakansson J, Wennstrom JL, Tomasi C, Berglundh T. Peri-implantitis - onset and pattern of progression. J Clin Periodontol 2016;43:383-8. https://doi.org/10.1111/jcpe.12535
- Araujo MG, Lindhe J. Peri-implant health. J Periodontol 2018;89 Suppl 1:S249-56. https://doi.org/10.1002/JPER.16-0424
- Carcuac O, Abrahamsson I, Albouy JP, Linder E, Larsson L, Berglundh T. Experimental periodontitis and peri-implantitis in dogs. Clin Oral Implants Res 2013;24:363-71. https://doi.org/10.1111/clr.12067
- Mombelli A, Lang NP. The diagnosis and treatment of peri-implantitis. Periodontol 2000 1998;17:63-76. https://doi.org/10.1111/j.1600-0757.1998.tb00124.x
- Heitz-Mayfield LJA, Salvi GE. ITI treatment guide volume 13- prevention and management of peri-implant diseases. Batavia: Quintessence Publishing; 2022.
- Sinjab K, Garaicoa-Pazmino C, Wang HL. Decision making for management of periimplant diseases. Implant Dent 2018;27:276-81. https://doi.org/10.1097/ID.0000000000000775
- Monje A. Unfolding peri-implantitis. 1. Batavia: Quintessence Publishing; 2022.
- Renvert S, Roos-Jansaker AM, Claffey N. Non-surgical treatment of peri-implant mucositis and periimplantitis: a literature review. J Clin Periodontol 2008;35 Suppl:305-15. https://doi.org/10.1111/j.1600-051X.2008.01276.x
- Linares A, Pico A, Blanco C, Blanco J. Adjunctive systemic metronidazole to nonsurgical therapy of peri-implantitis with intrabony defects: a retrospective case series study. Int J Oral Maxillofac Implants 2019;34:1237-45. https://doi.org/10.11607/jomi.7343
- Park SH, Song YW, Cha JK, Lee JS, Kim YT, Shin HS, et al. Adjunctive use of metronidazole-minocycline ointment in the nonsurgical treatment of peri-implantitis: a multicenter randomized controlled trial. Clin Implant Dent Relat Res 2021;23:543-54. Epub 2021 Jun 18. https://doi.org/10.1111/cid.13006
- Heitz-Mayfield LJ, Heitz F, Lang NP. Implant disease risk assessment IDRA-a tool for preventing periimplant disease. Clin Oral Implants Res 2020;31:397-403. https://doi.org/10.1111/clr.13585
- Meffert RM. How to treat ailing and failing implants. Implant Dent 1992;1:25-33. https://doi.org/10.1097/00008505-199200110-00003
- Scarano A, Carinci F, Quaranta A, Iezzi G, Piattelli M, Piattelli A. Correlation between implant stability quotient (ISQ) with clinical and histological aspects of dental implants removed for mobility. Int J Immunopathol Pharmacol 2007;20 Suppl 1:33-6. https://doi.org/10.1177/039463200702001s08
- Okayasu K, Wang HL. Decision tree for the management of periimplant diseases. Implant Dent 2011;20:256-61. https://doi.org/10.1097/ID.0b013e3182263589
- Decker AM, Sheridan R, Lin GH, Sutthiboonyapan P, Carroll W, Wang HL. A prognosis system for periimplant diseases. Implant Dent 2015;24:416-21. https://doi.org/10.1097/ID.0000000000000276
- Fu JH, Wang HL. Can periimplantitis be treated? Dent Clin North Am 2015;59:951-80. https://doi.org/10.1016/j.cden.2015.06.004
- Ravida A, Siqueira R, Di Gianfilippo R, Kaur G, Giannobile A, Galindo-Moreno P, et al. Prognostic factors associated with implant loss, disease progression or favorable outcomes after peri-implantitis surgical therapy. Clin Implant Dent Relat Res 2022;24:222-32. https://doi.org/10.1111/cid.13074
- Zhou W, Wang F, Monje A, Elnayef B, Huang W, Wu Y. Feasibility of dental implant replacement in failed sites: a systematic review. Int J Oral Maxillofac Implants 2016;31:535-45. https://doi.org/10.11607/jomi.4312
- Park YS, Lee BA, Choi SH, Kim YT. Evaluation of failed implants and reimplantation at sites of previous dental implant failure: survival rates and risk factors. J Periodontal Implant Sci 2022;52:230-41. https://doi.org/10.5051/jpis.2105020251
- Schwarz F, Derks J, Monje A, Wang HL. Peri-implantitis. J Periodontol 2018;89 Suppl 1:S267-90. https://doi.org/10.1002/JPER.16-0350
- Jepsen S, Berglundh T, Genco R, Aass AM, Demirel K, Derks J, et al. Primary prevention of peri-implantitis: managing peri-implant mucositis. J Clin Periodontol 2015;42 Suppl 16:S152-7. https://doi.org/10.1111/jcpe.12369
- Heitz-Mayfield LJ, Mombelli A. The therapy of peri-implantitis: a systematic review. Int J Oral Maxillofac Implants 2014;29 Suppl:325-45. https://doi.org/10.11607/jomi.2014suppl.g5.3
- Ramanauskaite A, Fretwurst T, Schwarz F. Efficacy of alternative or adjunctive measures to conventional non-surgical and surgical treatment of peri-implant mucositis and peri-implantitis: a systematic review and meta-analysis. Int J Implant Dent 2021;7:112. https://doi.org/10.1186/s40729-021-00388-x
- Schwarz F, John G, Hegewald A, Becker J. Non-surgical treatment of peri-implant mucositis and peri-implantitis at zirconia implants: a prospective case series. J Clin Periodontol 2015;42:783-8. https://doi.org/10.1111/jcpe.12439
- Klinge B, Meyle J; Working Group 2. Peri-implant tissue destruction. The Third EAO Consensus Conference 2012. Clin Oral Implants Res 2012;23 Suppl 6:108-10. https://doi.org/10.1111/j.1600-0501.2012.02555.x
- Salvi GE, Stahli A, Imber JC, Sculean A, Roccuzzo A. Physiopathology of peri-implant diseases. Clin Implant Dent Relat Res 2023;25:629-39. https://doi.org/10.1111/cid.13167
- Kim HJ, Ahn DH, Yu Y, Han H, Kim SY, Joo JY, et al. Microbial profiling of peri-implantitis compared to the periodontal microbiota in health and disease using 16S rRNA sequencing. J Periodontal Implant Sci 2023;53:69-84. https://doi.org/10.5051/jpis.2202080104
- Blanco C, Pico A, Dopico J, Gandara P, Blanco J, Linares A. Adjunctive benefits of systemic metronidazole on non-surgical treatment of peri-implantitis. A randomized placebo-controlled clinical trial. J Clin Periodontol 2022;49:15-27.
- Nart J, Pons R, Valles C, Esmatges A, Sanz-Martin I, Monje A. Non-surgical therapeutic outcomes of periimplantitis: 12-month results. Clin Oral Investig 2020;24:675-82. https://doi.org/10.1007/s00784-019-02943-8
- Ardila CM, Bedoya-Garcia JA, Arrubla-Escobar DE. Antibiotic resistance in periodontitis patients: a systematic scoping review of randomized clinical trials. Oral Dis 2023;29:2501-11. https://doi.org/10.1111/odi.14288
- Yi Y, Koo KT, Schwarz F, Ben Amara H, Heo SJ. Association of prosthetic features and peri-implantitis: a cross-sectional study. J Clin Periodontol 2020;47:392-403. https://doi.org/10.1111/jcpe.13251
- de Tapia B, Mozas C, Valles C, Nart J, Sanz M, Herrera D. Adjunctive effect of modifying the implant-supported prosthesis in the treatment of peri-implant mucositis. J Clin Periodontol 2019;46:1050-60. https://doi.org/10.1111/jcpe.13169
- Korello K, Eickholz P, Zuhr O, Ratka C, Petsos H. In vitro efficacy of non-surgical and surgical implant surface decontamination methods in three different defect configurations in the presence or absence of a suprastructure. Clin Implant Dent Relat Res 2023;25:549-63. https://doi.org/10.1111/cid.13198
- Schwarz F, Jepsen S, Obreja K, Galarraga-Vinueza ME, Ramanauskaite A. Surgical therapy of peri-implantitis. Periodontol 2000 2022;88:145-81. https://doi.org/10.1111/prd.12417
- Berglundh T, Wennstrom JL, Lindhe J. Long-term outcome of surgical treatment of peri-implantitis. A 2-11-year retrospective study. Clin Oral Implants Res 2018;29:404-10.. https://doi.org/10.1111/clr.13138
- Cha JK, Lee JS, Kim CS. Surgical therapy of peri-implantitis with local minocycline: a 6-month randomized controlled clinical trial. J Dent Res 2019;98:288-95. https://doi.org/10.1177/0022034518818479
- Sanz-Martin I, Cha JK, Sanz-Sanchez I, Figuero E, Herrera D, Sanz M. Changes in peri-implant soft tissue levels following surgical treatment of peri-implantitis: a systematic review and meta-analysis. 2021;32:230-44. https://doi.org/10.1111/clr.13840
- Burgueno-Barris G, Camps-Font O, Figueiredo R, Valmaseda-Castellon E. The influence of implantoplasty on surface roughness, biofilm formation, and biocompatibility of titanium implants: a systematic review. Syst Rev 2021;36:e111-9. https://doi.org/10.11607/jomi.8785
- Mombelli A, Hashim D, Cionca N. What is the impact of titanium particles and biocorrosion on implant survival and complications? Crit Rev 2018;29:37-53. https://doi.org/10.1111/clr.13305
- Bertl K, Isidor F, von Steyern PV, Stavropoulos A. Does implantoplasty affect the failure strength of narrow and regular diameter implants? A laboratory study. Clin Oral Investig 2021;25:2203-11. https://doi.org/10.1007/s00784-020-03534-8
- Englezos E, Cosyn J, Koole S, Jacquet W, De Bruyn H. Resective treatment of peri-implantitis: clinical and radiographic outcomes after 2 years. Int J Periodont Restor Dent 2018;38:729-35. https://doi.org/10.11607/prd.3386
- Monje A, Pons R, Insua A, Nart J, Wang HL, Schwarz F. Morphology and severity of peri-implantitis bone defects. Clin Implant Dent Relat Res 2019;21:635-43. https://doi.org/10.1111/cid.12791
- Froum SJ, Froum SH, Rosen PS. A regenerative approach to the successful treatment of peri-implantitis: a consecutive series of 170 implants in 100 patients with 2- to 10-year follow-up. Int J Periodont Restor Dent 2015;35:857-63. https://doi.org/10.11607/prd.2571
- Schwarz F, John G, Schmucker A, Sahm N, Becker J. Combined surgical therapy of advanced peri-implantitis evaluating two methods of surface decontamination: a 7-year follow-up observation. J Clin Periodontol 2017;44:337-42. https://doi.org/10.1111/jcpe.12648
- de Tapia B, Valles C, Ribeiro-Amaral T, Mor C, Herrera D, Sanz M, et al. The adjunctive effect of a titanium brush in implant surface decontamination at peri-implantitis surgical regenerative interventions: a randomized controlled clinical trial. J Clin Periodontol 2019;46:586-96. https://doi.org/10.1111/jcpe.13095
- Perussolo J, Souza AB, Matarazzo F, Oliveira RP, Araujo MG. Influence of the keratinized mucosa on the stability of peri-implant tissues and brushing discomfort: a 4-year follow-up study. Clin Oral Implants Res 2018;29:1177-85. https://doi.org/10.1111/clr.13381
- Garaicoa-Pazmino C, Mendonca G, Ou A, Chan HL, Mailoa J, Suarez-Lopez Del Amo F, et al. Impact of mucosal phenotype on marginal bone levels around tissue level implants: a prospective controlled trial. J Periodontol 2021;92:771-83. https://doi.org/10.1002/JPER.20-0458
- Gharpure AS, Latimer JM, Aljofi FE, Kahng JH, Daubert DM. Role of thin gingival phenotype and inadequate keratinized mucosa width (<2 mm) as risk indicators for peri-implantitis and peri-implant mucositis. J Periodontol 2021;92:1687-96. https://doi.org/10.1002/JPER.20-0792
- Stefanini M, Barootchi S, Sangiorgi M, Pispero A, Grusovin MG, Mancini L, et al. Do soft tissue augmentation techniques provide stable and favorable peri-implant conditions in the medium and long term? A systematic review. Clin Oral Implants Res 2023;34 Suppl 26:28-42. https://doi.org/10.1111/clr.14150
- Koo KT, Khoury F, Keeve PL, Schwarz F, Ramanauskaite A, Sculean A, et al. Implant surface decontamination by surgical treatment of periimplantitis: a literature review. Implant Dent 2019;28:173-6. https://doi.org/10.1097/ID.0000000000000840
- Luengo F, Sanz-Esporrin J, Noguerol F, Sanz-Martin I, Sanz-Sanchez I, Sanz M. In vitro effect of different implant decontamination methods in three intraosseous defect configurations. Clin Oral Implants Res 2022;33:1087-97. https://doi.org/10.1111/clr.13991
- Monje A, Amerio E, Cha JK, Kotsakis G, Pons R, Renvert S, et al. Strategies for implant surface decontamination in peri-implantitis therapy. Int J Oral Implantol (Berl) 2022;15:213-48.
- Francis S, Iaculli F, Perrotti V, Piattelli A, Quaranta A. Titanium surface decontamination: a systematic review of in vitro comparative studies. Int J Oral Maxillofac Implants 2022;37:76-84. https://doi.org/10.11607/jomi.8969
- Cha JK, Paeng K, Jung UW, Choi SH, Sanz M, Sanz-Martin I. The effect of five mechanical instrumentation protocols on implant surface topography and roughness: a scanning electron microscope and confocal laser scanning microscope analysis. Clin Oral Implants Res 2019;30:578-87. https://doi.org/10.1111/clr.13446
- Sirinirund B, Garaicoa-Pazmino C, Wang HL. Effects of mechanical instrumentation with commercially available instruments used in supportive peri-implant therapy: an in vitro study. Int J Oral Maxillofac Implants 2019;34:1370-8. https://doi.org/10.11607/jomi.7409
- Giffi R, Pietropaoli D, Mancini L, Tarallo F, Sahrmann P, Marchetti E. The efficacy of different implant surface decontamination methods using spectrophotometric analysis: an in vitro study. J Periodontal Implant Sci 2023;53:295-305.
- Suarez F, Monje A, Galindo-Moreno P, Wang HL. Implant surface detoxification: a comprehensive review. Implant Dent 2013;22:465-73. https://doi.org/10.1097/ID.0b013e3182a2b8f4
- Roccuzzo M, Mirra D, Pittoni D, Ramieri G, Roccuzzo A. Reconstructive treatment of peri-implantitis infrabony defects of various configurations: 5-year survival and success. Clin Oral Implants Res 2021;32:1209-17. https://doi.org/10.1111/clr.13818
- Heitz-Mayfield LJ, Salvi GE, Mombelli A, Loup PJ, Heitz F, Kruger E, et al. Supportive peri-implant therapy following anti-infective surgical peri-implantitis treatment: 5-year survival and success. Clin Oral Implants Res 2018;29:1-6. https://doi.org/10.1111/clr.12910
- Roccuzzo M, Layton DM, Roccuzzo A, Heitz-Mayfield LJ. Clinical outcomes of peri-implantitis treatment and supportive care: a systematic review. Clin Oral Implants Res 2018;29 Suppl 16:331-50. https://doi.org/10.1111/clr.13287
- Lee SB, Lee BA, Choi SH, Kim YT. Long-term outcomes after peri-implantitis treatment and their influencing factors: a retrospective study. J Periodontal Implant Sci 2022;52:194-205. https://doi.org/10.5051/jpis.2103020151
- Frisch E, Vach K, Ratka-Krueger P. Impact of supportive implant therapy on peri-implant diseases: a retrospective 7-year study. J Clin Periodontol 2020;47:101-9. https://doi.org/10.1111/jcpe.13206
- Monje A, Wang HL, Nart J. Association of preventive maintenance therapy compliance and peri-implant diseases: a cross-sectional study. J Periodontol 2017;88:1030-41. https://doi.org/10.1902/jop.2017.170135
- Monje A, Aranda L, Diaz KT, Alarcon MA, Bagramian RA, Wang HL, et al. Impact of maintenance therapy for the prevention of peri-implant diseases: a systematic review and meta-analysis. J Dent Res 2016;95:372-9. https://doi.org/10.1177/0022034515622432