DOI QR코드

DOI QR Code

Comprehensive treatment protocol for peri-implantitis: an up-to date narrative review of the literature

  • Inpyo Hong (Department of Periodontology, Research Institute of Periodontal Regeneration, Yonsei University College of Dentistry) ;
  • Ki-Tae Koo (Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Sang-Yoon Oh (Mapo Acro Dental Clinic) ;
  • Hwee Woong Park (Seoul Ace Dental Clinic) ;
  • Ignacio Sanz-Martin (Department of Periodontology, Research Institute of Periodontal Regeneration, Yonsei University College of Dentistry) ;
  • Jae-Kook Cha (Department of Periodontology, Research Institute of Periodontal Regeneration, Yonsei University College of Dentistry)
  • Received : 2023.07.24
  • Accepted : 2023.11.02
  • Published : 2024.10.30

Abstract

This narrative review describes up-to-date treatment options for peri-implantitis and proposes a treatment protocol and flowchart based on the current scientific evidence. Peri-implantitis treatment should be based on the phased treatment protocol for periodontitis, which is a continuous flow of decisions for extraction, nonsurgical and surgical treatments with step-by-step re-evaluation. The protocol's goals are to fulfill the success criteria for peri-implantitis treatment (probing depth of ≤5 mm, and absence of bleeding on probing, suppuration, and progressive bone loss) and to halt disease progression. Fixtures with peri-implantitis can initially be classified as failed or failing. A failed implant needs to be removed. In contrast, nonsurgical and surgical treatments can be applied to a failing implant. Nonsurgical treatment should be the initial treatment for failing implants; however, sole nonsurgical treatment was regarded as inefficient for peri-implantitis. Recent studies have found that the adjunctive use of antibiotics to nonsurgical debridement increased the success of nonsurgical treatment for peri-implantitis. Surgical treatments can be classified into resective, access, and reconstructive surgeries. The technique should be selected according to the patient's bone defect configuration, which relate to regenerative potential. Various combinations of decontamination methods (e.g., mechanical, chemical, and pharmacological approaches) are required to achieve absolute surface decontamination. Clinicians should select an appropriate surface decontamination strategy according to the purpose of surgery. After signs of disease disappear and its progression is halted through active peri-implantitis treatment, it is necessary to enroll patients into maintenance programs. Compliance of patients with the maintenance program reduces the recurrence of peri-implantitis and sustains clinical success after treatment. Maintenance visits should include professional plaque control and hygiene care reinforcement for patients, and their interval should be set according to individual peri-implantitis risk. Clinicians should remind that peri-implantitis treatment is not a single procedure, but rather a continuing cycle of treatment and re-evaluation.

Keywords

Acknowledgement

This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) & funded by Korean government (MSIT) (No. 2022M3A9F3016364).

References

  1. Berglundh T, Armitage G, Araujo MG, Avila-Ortiz G, Blanco J, Camargo PM, et al. Peri-implant diseases and conditions: consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol 2018;45 Suppl 1:S286-91.
  2. Derks J, Schaller D, Hakansson J, Wennstrom JL, Tomasi C, Berglundh T. Effectiveness of implant therapy analyzed in a swedish population: prevalence of peri-implantitis. J Dent Res 2016;95:43-9.
  3. Derks J, Schaller D, Hakansson J, Wennstrom JL, Tomasi C, Berglundh T. Peri-implantitis - onset and pattern of progression. J Clin Periodontol 2016;43:383-8.
  4. Araujo MG, Lindhe J. Peri-implant health. J Periodontol 2018;89 Suppl 1:S249-56.
  5. Carcuac O, Abrahamsson I, Albouy JP, Linder E, Larsson L, Berglundh T. Experimental periodontitis and peri-implantitis in dogs. Clin Oral Implants Res 2013;24:363-71.
  6. Mombelli A, Lang NP. The diagnosis and treatment of peri-implantitis. Periodontol 2000 1998;17:63-76.
  7. Heitz-Mayfield LJA, Salvi GE. ITI treatment guide volume 13- prevention and management of peri-implant diseases. Batavia: Quintessence Publishing; 2022.
  8. Sinjab K, Garaicoa-Pazmino C, Wang HL. Decision making for management of periimplant diseases. Implant Dent 2018;27:276-81.
  9. Monje A. Unfolding peri-implantitis. 1. Batavia: Quintessence Publishing; 2022.
  10. Renvert S, Roos-Jansaker AM, Claffey N. Non-surgical treatment of peri-implant mucositis and periimplantitis: a literature review. J Clin Periodontol 2008;35 Suppl:305-15.
  11. Linares A, Pico A, Blanco C, Blanco J. Adjunctive systemic metronidazole to nonsurgical therapy of peri-implantitis with intrabony defects: a retrospective case series study. Int J Oral Maxillofac Implants 2019;34:1237-45.
  12. Park SH, Song YW, Cha JK, Lee JS, Kim YT, Shin HS, et al. Adjunctive use of metronidazole-minocycline ointment in the nonsurgical treatment of peri-implantitis: a multicenter randomized controlled trial. Clin Implant Dent Relat Res 2021;23:543-54. Epub 2021 Jun 18.
  13. Heitz-Mayfield LJ, Heitz F, Lang NP. Implant disease risk assessment IDRA-a tool for preventing periimplant disease. Clin Oral Implants Res 2020;31:397-403.
  14. Meffert RM. How to treat ailing and failing implants. Implant Dent 1992;1:25-33.
  15. Scarano A, Carinci F, Quaranta A, Iezzi G, Piattelli M, Piattelli A. Correlation between implant stability quotient (ISQ) with clinical and histological aspects of dental implants removed for mobility. Int J Immunopathol Pharmacol 2007;20 Suppl 1:33-6.
  16. Okayasu K, Wang HL. Decision tree for the management of periimplant diseases. Implant Dent 2011;20:256-61.
  17. Decker AM, Sheridan R, Lin GH, Sutthiboonyapan P, Carroll W, Wang HL. A prognosis system for periimplant diseases. Implant Dent 2015;24:416-21.
  18. Fu JH, Wang HL. Can periimplantitis be treated? Dent Clin North Am 2015;59:951-80.
  19. Ravida A, Siqueira R, Di Gianfilippo R, Kaur G, Giannobile A, Galindo-Moreno P, et al. Prognostic factors associated with implant loss, disease progression or favorable outcomes after peri-implantitis surgical therapy. Clin Implant Dent Relat Res 2022;24:222-32.
  20. Zhou W, Wang F, Monje A, Elnayef B, Huang W, Wu Y. Feasibility of dental implant replacement in failed sites: a systematic review. Int J Oral Maxillofac Implants 2016;31:535-45.
  21. Park YS, Lee BA, Choi SH, Kim YT. Evaluation of failed implants and reimplantation at sites of previous dental implant failure: survival rates and risk factors. J Periodontal Implant Sci 2022;52:230-41.
  22. Schwarz F, Derks J, Monje A, Wang HL. Peri-implantitis. J Periodontol 2018;89 Suppl 1:S267-90.
  23. Jepsen S, Berglundh T, Genco R, Aass AM, Demirel K, Derks J, et al. Primary prevention of peri-implantitis: managing peri-implant mucositis. J Clin Periodontol 2015;42 Suppl 16:S152-7.
  24. Heitz-Mayfield LJ, Mombelli A. The therapy of peri-implantitis: a systematic review. Int J Oral Maxillofac Implants 2014;29 Suppl:325-45.
  25. Ramanauskaite A, Fretwurst T, Schwarz F. Efficacy of alternative or adjunctive measures to conventional non-surgical and surgical treatment of peri-implant mucositis and peri-implantitis: a systematic review and meta-analysis. Int J Implant Dent 2021;7:112.
  26. Schwarz F, John G, Hegewald A, Becker J. Non-surgical treatment of peri-implant mucositis and peri-implantitis at zirconia implants: a prospective case series. J Clin Periodontol 2015;42:783-8.
  27. Klinge B, Meyle J; Working Group 2. Peri-implant tissue destruction. The Third EAO Consensus Conference 2012. Clin Oral Implants Res 2012;23 Suppl 6:108-10.
  28. Salvi GE, Stahli A, Imber JC, Sculean A, Roccuzzo A. Physiopathology of peri-implant diseases. Clin Implant Dent Relat Res 2023;25:629-39.
  29. Kim HJ, Ahn DH, Yu Y, Han H, Kim SY, Joo JY, et al. Microbial profiling of peri-implantitis compared to the periodontal microbiota in health and disease using 16S rRNA sequencing. J Periodontal Implant Sci 2023;53:69-84.
  30. Blanco C, Pico A, Dopico J, Gandara P, Blanco J, Linares A. Adjunctive benefits of systemic metronidazole on non-surgical treatment of peri-implantitis. A randomized placebo-controlled clinical trial. J Clin Periodontol 2022;49:15-27.
  31. Nart J, Pons R, Valles C, Esmatges A, Sanz-Martin I, Monje A. Non-surgical therapeutic outcomes of periimplantitis: 12-month results. Clin Oral Investig 2020;24:675-82.
  32. Ardila CM, Bedoya-Garcia JA, Arrubla-Escobar DE. Antibiotic resistance in periodontitis patients: a systematic scoping review of randomized clinical trials. Oral Dis 2023;29:2501-11.
  33. Yi Y, Koo KT, Schwarz F, Ben Amara H, Heo SJ. Association of prosthetic features and peri-implantitis: a cross-sectional study. J Clin Periodontol 2020;47:392-403.
  34. de Tapia B, Mozas C, Valles C, Nart J, Sanz M, Herrera D. Adjunctive effect of modifying the implant-supported prosthesis in the treatment of peri-implant mucositis. J Clin Periodontol 2019;46:1050-60.
  35. Korello K, Eickholz P, Zuhr O, Ratka C, Petsos H. In vitro efficacy of non-surgical and surgical implant surface decontamination methods in three different defect configurations in the presence or absence of a suprastructure. Clin Implant Dent Relat Res 2023;25:549-63.
  36. Schwarz F, Jepsen S, Obreja K, Galarraga-Vinueza ME, Ramanauskaite A. Surgical therapy of peri-implantitis. Periodontol 2000 2022;88:145-81.
  37. Berglundh T, Wennstrom JL, Lindhe J. Long-term outcome of surgical treatment of peri-implantitis. A 2-11-year retrospective study. Clin Oral Implants Res 2018;29:404-10..
  38. Cha JK, Lee JS, Kim CS. Surgical therapy of peri-implantitis with local minocycline: a 6-month randomized controlled clinical trial. J Dent Res 2019;98:288-95.
  39. Sanz-Martin I, Cha JK, Sanz-Sanchez I, Figuero E, Herrera D, Sanz M. Changes in peri-implant soft tissue levels following surgical treatment of peri-implantitis: a systematic review and meta-analysis. 2021;32:230-44.
  40. Burgueno-Barris G, Camps-Font O, Figueiredo R, Valmaseda-Castellon E. The influence of implantoplasty on surface roughness, biofilm formation, and biocompatibility of titanium implants: a systematic review. Syst Rev 2021;36:e111-9.
  41. Mombelli A, Hashim D, Cionca N. What is the impact of titanium particles and biocorrosion on implant survival and complications? Crit Rev 2018;29:37-53.
  42. Bertl K, Isidor F, von Steyern PV, Stavropoulos A. Does implantoplasty affect the failure strength of narrow and regular diameter implants? A laboratory study. Clin Oral Investig 2021;25:2203-11.
  43. Englezos E, Cosyn J, Koole S, Jacquet W, De Bruyn H. Resective treatment of peri-implantitis: clinical and radiographic outcomes after 2 years. Int J Periodont Restor Dent 2018;38:729-35.
  44. Monje A, Pons R, Insua A, Nart J, Wang HL, Schwarz F. Morphology and severity of peri-implantitis bone defects. Clin Implant Dent Relat Res 2019;21:635-43.
  45. Froum SJ, Froum SH, Rosen PS. A regenerative approach to the successful treatment of peri-implantitis: a consecutive series of 170 implants in 100 patients with 2- to 10-year follow-up. Int J Periodont Restor Dent 2015;35:857-63.
  46. Schwarz F, John G, Schmucker A, Sahm N, Becker J. Combined surgical therapy of advanced peri-implantitis evaluating two methods of surface decontamination: a 7-year follow-up observation. J Clin Periodontol 2017;44:337-42.
  47. de Tapia B, Valles C, Ribeiro-Amaral T, Mor C, Herrera D, Sanz M, et al. The adjunctive effect of a titanium brush in implant surface decontamination at peri-implantitis surgical regenerative interventions: a randomized controlled clinical trial. J Clin Periodontol 2019;46:586-96.
  48. Perussolo J, Souza AB, Matarazzo F, Oliveira RP, Araujo MG. Influence of the keratinized mucosa on the stability of peri-implant tissues and brushing discomfort: a 4-year follow-up study. Clin Oral Implants Res 2018;29:1177-85.
  49. Garaicoa-Pazmino C, Mendonca G, Ou A, Chan HL, Mailoa J, Suarez-Lopez Del Amo F, et al. Impact of mucosal phenotype on marginal bone levels around tissue level implants: a prospective controlled trial. J Periodontol 2021;92:771-83.
  50. Gharpure AS, Latimer JM, Aljofi FE, Kahng JH, Daubert DM. Role of thin gingival phenotype and inadequate keratinized mucosa width (<2 mm) as risk indicators for peri-implantitis and peri-implant mucositis. J Periodontol 2021;92:1687-96.
  51. Stefanini M, Barootchi S, Sangiorgi M, Pispero A, Grusovin MG, Mancini L, et al. Do soft tissue augmentation techniques provide stable and favorable peri-implant conditions in the medium and long term? A systematic review. Clin Oral Implants Res 2023;34 Suppl 26:28-42.
  52. Koo KT, Khoury F, Keeve PL, Schwarz F, Ramanauskaite A, Sculean A, et al. Implant surface decontamination by surgical treatment of periimplantitis: a literature review. Implant Dent 2019;28:173-6.
  53. Luengo F, Sanz-Esporrin J, Noguerol F, Sanz-Martin I, Sanz-Sanchez I, Sanz M. In vitro effect of different implant decontamination methods in three intraosseous defect configurations. Clin Oral Implants Res 2022;33:1087-97.
  54. Monje A, Amerio E, Cha JK, Kotsakis G, Pons R, Renvert S, et al. Strategies for implant surface decontamination in peri-implantitis therapy. Int J Oral Implantol (Berl) 2022;15:213-48.
  55. Francis S, Iaculli F, Perrotti V, Piattelli A, Quaranta A. Titanium surface decontamination: a systematic review of in vitro comparative studies. Int J Oral Maxillofac Implants 2022;37:76-84.
  56. Cha JK, Paeng K, Jung UW, Choi SH, Sanz M, Sanz-Martin I. The effect of five mechanical instrumentation protocols on implant surface topography and roughness: a scanning electron microscope and confocal laser scanning microscope analysis. Clin Oral Implants Res 2019;30:578-87.
  57. Sirinirund B, Garaicoa-Pazmino C, Wang HL. Effects of mechanical instrumentation with commercially available instruments used in supportive peri-implant therapy: an in vitro study. Int J Oral Maxillofac Implants 2019;34:1370-8.
  58. Giffi R, Pietropaoli D, Mancini L, Tarallo F, Sahrmann P, Marchetti E. The efficacy of different implant surface decontamination methods using spectrophotometric analysis: an in vitro study. J Periodontal Implant Sci 2023;53:295-305.
  59. Suarez F, Monje A, Galindo-Moreno P, Wang HL. Implant surface detoxification: a comprehensive review. Implant Dent 2013;22:465-73.
  60. Roccuzzo M, Mirra D, Pittoni D, Ramieri G, Roccuzzo A. Reconstructive treatment of peri-implantitis infrabony defects of various configurations: 5-year survival and success. Clin Oral Implants Res 2021;32:1209-17.
  61. Heitz-Mayfield LJ, Salvi GE, Mombelli A, Loup PJ, Heitz F, Kruger E, et al. Supportive peri-implant therapy following anti-infective surgical peri-implantitis treatment: 5-year survival and success. Clin Oral Implants Res 2018;29:1-6.
  62. Roccuzzo M, Layton DM, Roccuzzo A, Heitz-Mayfield LJ. Clinical outcomes of peri-implantitis treatment and supportive care: a systematic review. Clin Oral Implants Res 2018;29 Suppl 16:331-50.
  63. Lee SB, Lee BA, Choi SH, Kim YT. Long-term outcomes after peri-implantitis treatment and their influencing factors: a retrospective study. J Periodontal Implant Sci 2022;52:194-205.
  64. Frisch E, Vach K, Ratka-Krueger P. Impact of supportive implant therapy on peri-implant diseases: a retrospective 7-year study. J Clin Periodontol 2020;47:101-9.
  65. Monje A, Wang HL, Nart J. Association of preventive maintenance therapy compliance and peri-implant diseases: a cross-sectional study. J Periodontol 2017;88:1030-41.
  66. Monje A, Aranda L, Diaz KT, Alarcon MA, Bagramian RA, Wang HL, et al. Impact of maintenance therapy for the prevention of peri-implant diseases: a systematic review and meta-analysis. J Dent Res 2016;95:372-9.