Allergy, Asthma & Respiratory Disease

  • 제12권1호
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  • Pages.3-8
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  • 2024
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  • 2288-0402(pISSN)
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  • 2288-0410(eISSN)
대한천식알레르기학회 (The Korean Academy of Asthma, Allergy and Clinical Immunology)
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알레르기비염과 위생가설

Allergic rhinitis and hygiene hypothesis

  • 지혜미 (차의과학대학교 의학전문대학원 분당차병원 소아청소년과) ;
  • 김민지 (충남대학교 의과대학 세종충남대학교병원 소아청소년과) ;
  • 김현희 (가톨릭대학교 의과대학 소아과학교실) ;
  • 김효빈 (인제대학교 상계백병원 소아청소년과) ;
  • 나영호 (경희대학교 의과대학 소아청소년과학교실) ;
  • 박양 (원광대학교 의과대학 장흥통합의료병원 소아청소년과) ;
  • 성명순 (순천향대학교 구미병원 소아청소년과) ;
  • 신윤호 (차의과학대학교 의학전문대학원 강남차병원 소아청소년과) ;
  • 염혜영 (서울의료원 소아청소년과) ;
  • 이경석 (한양대학교 의과대학 소아청소년과학교실) ;
  • 이용주 (연세대학교 의과대학 용인세브란스병원 소아청소년과) ;
  • 전윤홍 (가톨릭대학교 의과대학 소아과학교실) ;
  • 최봉석 (경북대학교 의과대학 소아과학교실) ;
  • 최선희 (경희대학교 의과대학 소아청소년과학교실) ;
  • 박용민 (건국대학교 의학전문대학원 소아과학교실) ;
  • 대한 소아알레르기 호흡기학회 비염연구회 (대한 소아알레르기 호흡기학회)
  • Hye Mi Jee (Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Minji Kim (Department of Pediatrics, Chungnam National University Sejong Hospital, Chungnam National University College of Medicine) ;
  • Hyun Hee Kim (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Hyo-Bin Kim (Department of Pediatrics, Inje University Sanggye Paik Hospital) ;
  • Yeong-Ho Rha (Department of Pediatrics, School of Medicine, Kyung Hee University) ;
  • Yang Park (Department of Pediatrics, Jangheung Integrative Medical Hospital, Wonkwang University School of Medicine) ;
  • Myongsoon Sung (Department of Pediatrics, Soonchunhyang University Gumi Hospital) ;
  • Youn Ho Shin (Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine) ;
  • Hye Yung Yum (Department of Pediatrics, Seoul Medical Center) ;
  • Kyung Suk Lee (Department of Pediatrics, Hanyang University Guri Hospital, Hanyang University College of Medicine) ;
  • Yong Ju Lee (Department of Pediatrics, Yongin Severance Hospital, Yonsei University College of Medicine) ;
  • Yoon Hong Chun (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Bong Seok Choi (Department of Pediatrics, School of Medicine, Kyungpook National University) ;
  • Sun Hee Choi (Department of Pediatrics, School of Medicine, Kyung Hee University) ;
  • Yong Mean Park (Department of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine) ;
  • Rhinitis Study Group in the Korean Academy of Pediatric Allergy and Respiratory Diseases (Korean Academy of Pediatric Allergy and Respiratory Diseases)
  • 투고 : 2023.08.03
  • 심사 : 2023.09.07
  • 발행 : 2024.01.30
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초록

The hygiene hypothesis, first proposed in 1989, suggested that reduced exposure to infections in early life leads to allergic diseases by the defects in the establishment of immune tolerance. Although many studies provided evidence that some exposure conditions, including family size, antibiotics, probiotics, and viral or bacterial infections, are strongly related to the prevalence of allergic diseases, thereby supporting the hygiene hypothesis, some evidence does not provide acceptable results for the hygiene hypothesis. Further, most studies have focused on patients with asthma or atopic dermatitis, not allergic rhinitis. In this review, we summarize the recent studies for and against the 'hygiene hypothesis' and identify causal association with the prevalence of allergic rhinitis.

키워드

참고문헌

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