Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Integrating Conventional and Holistic Medicine through Standardized Medical Knowledge: Using Modern Physiology as a Stepping Stone to Explain Byeon-Jeung in Korean Medicine

표준화된 의학 지식을 통한 의학과 한의학의 통합 : 현대 생리학을 디딤돌 삼아 한의 변증 설명하기

  • Nima Nahvi (School of Korean Medicine, Pusan National University) ;
  • Hyungwoo Kim (School of Korean Medicine, Pusan National University)
  • 나비 니마 (부산대학교 한의학전문대학원) ;
  • 김형우 (부산대학교 한의학전문대학원)
  • Received : 2024.09.25
  • Accepted : 2024.10.23
  • Published : 2024.10.25
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Abstract

Over the past several decades there have been many attempts to integrate the fields of Conventional and Holistic medicine. However, to date, successful integration has yet to be achieved. For the purpose of providing greater understanding and effective methods for the diagnostic and treatment of functional body disorders this review presents a plausible method for successful consolidation of the reductionism and holism concepts present at the core of modern and traditional medicine. Reconstruction of modern physiological knowledge and understanding of changes in cardiovascular function was used to provide explanations for symptoms associated with the concept of Byeon-Jeung in Korean Medicine. The symptoms correlated with the Byeon-Jeung for Liver Qi Stagnation, Spleen Qi Deficiency, and Stomach Yin Deficiency were shown to be linked to decreases in blood flow and the corresponding functional disorders associated with such. These results demonstrate how modern physiological understanding of the body can serve as an appropriate stepping stone to assist in the integration of Conventional and Holisitic medicine.

Keywords

Acknowledgement

이 성과는 정부 (과학기술정보통신부)의 재원으로 한국연구재단의 지원을 받아 수행된 연구임 (No. 2022R1A2C2091960).

References

  1. Burton C, Fink P, Henningsen P, Lowe B, Rief W. Functional somatic disorders: discussion paper for a new common classification for research and clinical use. BMC Med. 2020;18(1):34. 
  2. Ahn AC, Tewari M, Poon CS, Phillips RS. The limits of reductionism in medicine: could systems biology offer an alternative? PLoS Med. 2006;3(6):e208. 
  3. Tabish SA. Complementary and Alternative Healthcare: Is it Evidence-based? Int J Health Sci (Qassim). 2008;2(1):5-9. 
  4. Gordon JS. Holistic medicine: advances and shortcomings. West J Med. 1982;136(6):546-51. 
  5. Fan D. Holistic integrative medicine: toward a new era of medical advancement. Front Med. 2017;11(1):152-9. 
  6. Xie J, Xu D, Wang C, Huang J. Jiawei Xiaoyao San in treatment of anxiety disorder and anxiety: A review. Chin Herb Med. 2023;15(2):214-21 
  7. Deutsch JK, Levitt J, Hass DJ. Complementary and Alternative Medicine for Functional Gastrointestinal Disorders. Am J Gastroenterol. 2020;115(3):350-64. 
  8. Yoon JY, Ko SJ, Park JW, Cha JM. Complementary and alternative medicine for functional dyspepsia: An Asian perspective. Medicine (Baltimore). 2022;101(35):e30077. 
  9. Nam DH, Hwang MW, Jang ES, Jeong Kim JY, Park JH et al. Clinical Practice Guideline of Korean Medicine: Chronic Fatigue. Korea, Ministry of Health and Welfare, National Institute for Korean Medicine Development; 2021. 
  10. Gannotta R, Malik S, Chan AY, Urgun K, Hsu F, Vadera S. Integrative Medicine as a Vital Component of Patient Care. Cureus. 2018;10(8):e3098. 
  11. Maizes V, Rakel D, Niemiec C. Integrative medicine and patient-centered care. Explore (NY). 2009;5(5):277-89. 
  12. Tilburt JC, Kaptchuk TJ. Herbal medicine research and global health: an ethical analysis. Bull World Health Organ. 2008;86(8):594-9. 
  13. Leeuwis AE, Smith LA, Melbourne A, Hughes AD, Richards M, Prins ND, et al. Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study. Front Aging Neurosci. 2018;10:279. 
  14. Chi C. Integrating traditional medicine into modern health care systems: examining the role of Chinese medicine in Taiwan. Soc Sci Med. 1994;39(3):307-21. 
  15. Fabrega H Jr. Medical validity in Eastern and Western traditions. Perspect Biol Med. 2002;45(3):395-415. 
  16. Schveitzer MC, Abdala CVM, Portella CFS, Ghelman R. Traditional, complementary, and integrative medicine evidence map: a methodology to an overflowing field of data and noise. Rev Panam Salud Publica. 2021;45:e48. 
  17. World Health Organization. WHO traditional medicine strategy: Geneva: WHO; 2014. 2014-2023. 
  18. Ogoh, S. Relationship between cognitive function and regulation of cerebral blood flow. J Physiol Sci. 2017;67:345-51. 
  19. Lassen, N. A., Ingvar, D. H., & Skinhoj, E. Brain Function and Blood Flow. Scientific American, 1978;239(4):62-71. 
  20. Chaudhry R, Miao JH, Rehman A. Physiology, Cardiovascular. In: StatPearls [Internet]. 2022 Oct [cited 2024 Sep 14]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK493197/ 
  21. Kim SH, Seo HW, Seo JW. Clinical Practice Guideline of Korean Medicine: Depression. Korea, Ministry of Health and Welfare, National Institute for Korean Medicine Development; 2024. 
  22. Won E, Kim YK. Stress, the Autonomic Nervous System, and the Immune-kynurenine Pathway in the Etiology of Depression. Curr Neuropharmacol. 2016;14(7):665-73. 
  23. Schneiderman N, Ironson G, Siegel SD. Stress and health: psychological, behavioral, and biological determinants. Annu Rev Clin Psychol. 2005;1:607-28. 
  24. Paravati S, Rosani A, Warrington SJ. Physiology, Catecholamines. In: StatPearls [Internet]. 2022 Oct [cited 2024 Sep 14] Available from: https://www.ncbi.nlm.nih.gov/books/NBK507716/ 
  25. Lopes AR, Moreira MD, Trelha CS, Marchiori LL. Association between complaints of dizziness and hypertension in non-institutionalized elders. Int Arch Otorhinolaryngol. 2013;17(2):157-62. 
  26. Hall, John E, and Michael E Hall. Guyton and Hall Textbook of Medical Physiology. 12th ed. Korean Translation. Korea: Elsevier Korea LLC; 2012. p. 286, 307, 326-327, 363, 621-2, 820, 830, 887 
  27. Browning KN, Travagli RA. Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions. Compr Physiol. 2014;4(4):1339-68. 
  28. Charkoudian N, Rabbitts JA. Sympathetic neural mechanisms in human cardiovascular health and disease. Mayo Clin Proc. 2009;84(9):822-30. 
  29. Park JW, Ko SJ, Han KJ, Kim WW, Lee YS, Kong KH, Kim SY Clinical Practice Guideline of Korean Medicine: Irritable Bowel Syndrom. Korea, Ministry of Health and Welfare, National Institute for Korean Medicine Development; 2024. 
  30. Lee MS, Hwang JT, Kim SH, Yoon S, Kim MS, Yang HJ, Kwon DY. Ginsenoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism. J Ethnopharmacol. 2010;127(3):771-6. 
  31. Chemical Equilibrium. In Brown, Theodore L, et al. Chemistry: The Central Science. Glenview: Pearson Education Limited, 15th ed. 2021. p 630-41. 
  32. Lund J, Ouwens DM, Wettergreen M, Bakke SS, Thoresen GH, Aas V. Increased Glycolysis and Higher Lactate Production in Hyperglycemic Myotubes. Cells. 2019;8(9):1101. 
  33. Alfarouk KO, Verduzco D, Rauch C, Muddathir AK, Adil HH, Elhassan GO, et al. Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question. Oncoscience. 2014;1(12):777-802. 
  34. Zhang L, Chen X, Cheng Y, Chen Q, Tan H, Son D, Chang D, Bian Z, Fang H, Xu H. Safety and antifatigue effect of Korean Red Ginseng: a randomized, double-blind, and placebo-controlled clinical trial. J Ginseng Res. 2019;43(4):676-83. 
  35. Robbins and Cotran Pathological Basis of Disease 9th ed. Korean Translation. Korea: Elsevier Korea LLC; 2018. p. 852-3. 
  36. Paton JF, Boscan P, Pickering AE, Nalivaiko E. The yin and yang of cardiac autonomic control: vago-sympathetic interactions revisited. Brain Res Brain Res Rev. 2005;49(3):555-65. 
  37. Hu WC. Yin-Yang in Traditional Medicine and Its Relation to Parasympathetic (NO-cGMP) and Sympathetic(CO-cAMP) Balance. J Chin Med. 27(1):2701003:1-6 
  38. Licht CM, Vreeburg SA, van Reedt Dortland AK, Giltay EJ, Hoogendijk WJ, DeRijk RH, et al. Increased sympathetic and decreased parasympathetic activity rather than changes in hypothalamic-pituitary-adrenal axis activity is associated with metabolic abnormalities. J Clin Endocrinol Metab. 2010;95(5):2458-66. 
  39. Jacobson ED, Linford RH, Grossman MI. Gastric secretion in relation to mucosal blood flow studied by a clearance technic. J Clin Invest. 1966;45(1):1-13. 
  40. Ko SJ, Kim JS, Park JW, Ha NY. Clinical Practice Guideline of Korean Medicine: Functional Dyspepsia. Korea, Ministry of Health and Welfare, National Institute for Korean Medicine Development; 2021. 
  41. Bjorne H H, Petersson J, Phillipson M, Weitzberg E, Holm L, Lundberg JO. Nitrite in saliva increases gastric mucosal blood flow and mucus thickness. J Clin Invest. 2004 Jan;113(1):106-14. doi: 10.1172/JCI19019. Erratum in: J Clin Invest. 2004;113(3):490. 
  42. Proctor GB, Carpenter GH. Regulation of salivary gland function by autonomic nerves. Auton Neurosci. 2007;133(1):3-18. 
  43. Gastrointestinal Circulation and Mucosal Pathology I:Ischemia/Reperfusion. In. Kvietys PR. The Gastrointestinal Circulation. San Rafael: Morgan & Claypool Life Sciences; 2010. 
  44. Matheson PJ, Wilson MA, Garrison RN. Regulation of intestinal blood flow. J Surg Res. 2000;93(1):182-96. 
  45. Ikechi R, Fischer BD, DeSipio J, Phadtare S. Irritable Bowel Syndrome: Clinical Manifestations, Dietary Influences, and Management. Healthcare (Basel). 2017;5(2):21. 
  46. Xu Q, Yaksh TL. A brief comparison of the pathophysiology of inflammatory versus neuropathic pain. Curr Opin Anaesthesiol. 2011;24(4):400-7. 
  47. Jones, Elizabeth A., et al. "What determines blood vessel structure? genetic prespecification vs. hemodynamics." Physiology, 2006;21(6):388-95. 
  48. Wilkinson DJ, Smeeton NJ, Watt PW. Ammonia metabolism, the brain and fatigue; revisiting the link. Prog Neurobiol. 2010;91(3):200-19. 
  49. Jason LA, Evans M, Brown M, Porter N. What is fatigue? Pathological and nonpathological fatigue. PM R. 2010;2(5):327-31. 
  50. Gregory K, Alexandros V, George C. Fatigue, Endocrinopathies, and Metabolic Disorders. PM&R, 2010;2(5):393-8. 
  51. Vasenina, E.E., Gankina, O.A. & Levin, O.S. Stress, Asthenia, and Cognitive Disorders. Neurosci Behav Physi. 2022;52:1341-7. 
  52. Wan JJ, Qin Z, Wang PY, Sun Y, Liu X. Muscle fatigue: general understanding and treatment. Exp Mol Med. 2017;49(10):e384. 
  53. Arring NM, Millstine D, Marks LA, Nail LM. Ginseng as a Treatment for Fatigue: A Systematic Review. J Altern Complement Med. 2018;24(7):624-33.