Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Inhibitory Effects of Codonopsis lanceolata Root Extract on Cell Proliferation and Invasion in Human A549 Lung Cancer Cells

인간 A549 폐암 세포에서 더덕 뿌리 추출물의 세포 증식 및 침습 억제 효과

  • 박영미 ((주)인비보) ;
  • 배준상 (원광대학교 한의과대학 병리학교실)
  • Received : 2024.09.06
  • Accepted : 2024.10.29
  • Published : 2024.10.25
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Abstract

Non-small cell lung cancer(NSCLC) is a highly malignant tumor with limited treatment options. Conventional chemotherapy significant has limitations, including drug resistance and side effects. In this study, we investigated the anticancer effects of Codonopsis lanceolata root extract(CLRE), a traditional medicinal herb, on the human lung cancer cell line A549. Our results showed that CLRE inhibited A549 cell proliferation, migration, and invasion. Furthermore, CLRE effectively suppressed epithelial-to-mesenchymal transition(EMT) markers, including N-cadherin, vimentin, and MMP-9, induced by TGF-β1. Also CLRE inhibited cell migration and invasion in A549 cells through the downregulation of the PI3K/AKT signaling pathway. These findings suggest that CLRE has potential as a natural anticancer agent or adjunct therapy for NSCLC by inhibiting cell proliferation and EMT processes. Further studies are needed to elucidate the underlying mechanisms and assess the safety and therapeutic potential of CLRE in preclinical and clinical studies.

Keywords

Acknowledgement

이 논문은 2023학년도 원광대학교의 교비지원에 의해 수행됨

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