Journal of Food Hygiene and Safety (한국식품위생안전성학회지)

The Korean Society of Food Hygiene and Safety (한국식품위생안전성학회)
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Domoic acid: Toxicity, Analytical Methods, and Safety Management

도모익산 군 독소: 독성, 분석법 및 관리 동향

  • Kyoungah Lee (Institute of Environmental Protection and Safety, NEB Co.) ;
  • Youngjin Kim (Institute of Environmental Protection and Safety, NEB Co.) ;
  • Kanghyun Lee (Institute of Environmental Protection and Safety, NEB Co.) ;
  • Namhyun Kim (Institute of Environmental Protection and Safety, NEB Co.) ;
  • Jang Kyun Kim (Department of Marine Science, College of Natural Sciences, Incheon National University) ;
  • Youn-Jung Kim (Department of Marine Science, College of Natural Sciences, Incheon National University) ;
  • Jungsuk Lee (Institute of Environmental Protection and Safety, NEB Co.) ;
  • Young-Seok Han (Institute of Environmental Protection and Safety, NEB Co.)
  • Received : 2024.08.22
  • Accepted : 2024.10.10
  • Published : 2024.10.30
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Abstract

Domoic acid group toxins are a class of marine biotoxins associated with amnesic shellfish poisoning (ASP). These toxins are primarily synthesized by Pseudonitzschia spp., diatoms which proliferate in coastal waters and accumulate in bivalve mollusks, potentially causing toxicity upon consumption. In Korea, Pseudonitzschia spp. blooms are predominantly observed in spring and fall. Regulatory standards for domoic acid group toxins in marine products are being developed and enforced to address the issue of ASP. The World Health Organization (WHO) and the European Food Safety Authority (EFSA) are actively proposing and managing safety thresholds to mitigate human exposure. This review provides a comprehensive overview of the physicochemical properties of domoic acid toxins, analytical methods for their detection, documented cases of human exposure, and current domestic and international regulatory frameworks. This study establishes a robust foundation for systematic monitoring and effective safety management of domoic acid group toxins.

도모익산(domoic acid) 군 독소는 기억상실성 패류중독(amnesic shellfish poison, ASP)을 유발하는 해양생물독소이다. 도모익산은 주로 규조류 Pseudonitzchia sp. 에서 생성되어 이매패류의 체내에 축적되어 독화된다. 우리나라 연안에서는 봄철과 가을철에 Pseudonitzchia sp.의 출현이 보고되고 있으며, 수산물 내 도모익산 군 독소의 함량 기준을 설정하여 관리하고 있다. WHO와 EFSA에서는 선제적 안전관리를 위하여 인체노출안전기준안을 제안하여 관리하고 있다. 본 연구는 도모익산 군 독소의 이화학적 특성, 분석법, 인체 노출 사례와 국내외 관리 현황 등의 자료를 검토하여 도모익산 군 독소의 체계적인 모니터링과 안전관리의 기반을 마련하고자 수행되었다.

Keywords

Acknowledgement

본 연구는 2024년도 식품의약품안전처의 연구개발비(20163MFDS641)로 수행되었으며 이에 감사드립니다.

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