Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)

Korean Society of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회)
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Estimation of the Biological Effectiveness of Auger Electron-Emitting Radiopharmaceuticals for Targeted Radiotherapy

  • Teresa W. Na (Korea Institute of Radiological and Medical Sciences) ;
  • Jung-Young Kim (Korea Institute of Radiological and Medical Sciences) ;
  • Kwang Il Kim (Korea Institute of Radiological and Medical Sciences) ;
  • Ilsung Cho (Korea Institute of Radiological and Medical Sciences)
  • Received : 2024.06.17
  • Accepted : 2024.06.26
  • Published : 2024.06.30
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Abstract

Relative biological effectiveness (RBE) plays an important role in relating physical dose to cell-killing biological dose. The calculation of the RBE is an important basic task in realization of radionuclide therapy using 64Cu. In this study, the method of calculating the RBE of emitted particles from 64Cu is presented using Monte Carlo simulation. U-87 MG cell model is designed to perform Monte Carlo simulation. The Geant4 simulation tool kit was used to simulate the secondary particles for transport into media. The specific energy in the cell nucleus and the domain was estimated. The Microdosimetric Kinetic model (MK model) is used to estimate RBE. The method presented in this study may be helpful to estimate biological dose in treatment with 64Cu.

Keywords

Acknowledgement

This work was supported in part by the National Research Foundation of Korea (NRF) funded by the Government of Korea [Ministry of Science and ICT (MSIT)] under Grant 2021-M2E7A2079182. This study was also supported by a grant of the Korea Institute of Radiological and Medical Sciences (KIRAMS), funded by the Ministry of Science and ICT (MSIT), Republic of Korea (Grant No. 50461-2024 and 50462-2024).

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