Korean Journal of Fisheries and Aquatic Sciences (한국수산과학회지)

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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In Vitro Screening of Gloiopeltis tenax Extracts Antioxidant and Anti-dementia Activities

참풀가사리(Gloiopeltis tenax) 추출물의 항산화성 및 항치매활성

  • Ji-Youn Kim (Department of Food Science & Biotechnology/Fisheries Science Institute, Kunsan National University) ;
  • Da-Bin Park (Department of Food Science & Biotechnology/Fisheries Science Institute, Kunsan National University) ;
  • Yeon-Ji Lee (Department of Food Science & Biotechnology/Fisheries Science Institute, Kunsan National University) ;
  • Soo-Kyung Moon (Department of Food and Nutrition/Institute of Agriculture and Life Science, Gyeongsang National University) ;
  • Yong-Tae Kim (Department of Food Science & Biotechnology/Fisheries Science Institute, Kunsan National University)
  • 김지윤 (국립군산대학교 식품생명공학과/수산과학연구소) ;
  • 박다빈 (국립군산대학교 식품생명공학과/수산과학연구소) ;
  • 이연지 (국립군산대학교 식품생명공학과/수산과학연구소) ;
  • 문수경 (경상국립대학교 식품영양학과/농업생명과학연구원) ;
  • 김용태 (국립군산대학교 식품생명공학과/수산과학연구소)
  • Received : 2024.06.17
  • Accepted : 2024.09.12
  • Published : 2024.10.31
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Abstract

In this study, we investigated the antioxidant and anti-dementia activities of the Korean marine algae Gloiopeltis tenax. Solvent extracts were prepared using 70% ethanol, 80% methanol, and distilled water. The extraction yields from the different solvents ranged from 8.52% to 49.47%. The total polyphenol and flavonoid contents ranged from 9.13-15.80 mg/g and 0.42-3.33 mg/g, respectively. The ethanol extract showed the highest 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activity, whereas the methanol extract exhibited the strongest reducing power and ferric reducing antioxidant power. Additionally, both the ethanol and methanol extracts exhibited higher acetylcholinesterase inhibitory activities (IC50=0.89-0.95 mg/mL) than that of the water extract. In contrast, the water extract exhibited the highest β-secretase inhibitory activity (IC50=17.03 ㎍/mL). These results indicate that G. tenax may be useful as an antioxidant and functional ingredient for food and pharmaceuticals, particularly for its anti-dementia properties.

Keywords

Acknowledgement

이 논문은 2024년도 국립군산대학교 수산과학연구소 학술연구비 지원을 받아 수행된 연구입니다.

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