대한한의학회지 (The Journal of Korean Medicine)

  • 제45권3호
  • /
  • Pages.143-153
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  • 2024
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  • 1010-0695(pISSN)
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  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
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Puriton®의 급성 췌장염에 대한 보호 효과

Protective effects of Puriton® on acute pancreatitis

  • 김동욱 (원광대학교 한의과대학 약리학교실) ;
  • 권빛나 (원광대학교 한의과대학 약리학교실) ;
  • 김광호 ((주)카데시인코퍼레이션) ;
  • 배기상 (원광대학교 한의과대학 약리학교실) ;
  • 송경 (원광대학교 약학대학 약학과)
  • Dong-Uk Kim (Department of Pharmacology, College of Korean Medicine, Wonkwang University) ;
  • Bitna Kweon (Department of Pharmacology, College of Korean Medicine, Wonkwang University) ;
  • Kwang-Ho Kim (Kadesh, Inc.) ;
  • Gi-Sang Bae (Department of Pharmacology, College of Korean Medicine, Wonkwang University) ;
  • Kyung Song (Department of Pharmacy, College of Pharmacy, Wonkwang University )
  • 투고 : 2024.07.23
  • 심사 : 2024.08.19
  • 발행 : 2024.09.01
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초록

Objectives: Puriton® is the electrolyte enriched water consisting of 31 essential minerals from biotite, kaolinite, montmorillonite, serpentine, and clinochlore, and vermiculite. It has been reported to be bactericidal and virucidal. However, the protective effect of Puriton® against acute pancreatitis (AP) has not yet been studied. Therefore, we aimed to evaluate the protective effect of Puriton® against cerulein-induced AP. Methods: AP was induced by intraperitoneal injections of cerulein (50 ㎍/kg) hourly for 6 times. Puriton® (100, 300, 500, or 700 μL) was administered orally 1 hour before the first cerulein injection. Mice were sacrificed 6 hours after the last cerulein injection. Pancreas, lung, and serum samples were quickly collected for further analysis. Results: Administration of Puriton® did not reduce the ratio of pancreas weight to body weight. However, the increased serum amylase and lipase were decreased in the Puriton® administration group, and histological damage to pancreas and lung tissue was suppressed in the Puriton® 100 and 300 μL administration groups, but not in the Puriton® 500 and 700 μL administration groups. Additionally, among pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, the mRNA level of only IL-6 was decreased by Puriton® administration. Conclusion: In summary, we showed that the administration of Puriton® improved the severity of cerulein-induced AP, suggesting the possibility of being an effective drug for AP.

키워드

과제정보

본 연구는 정부의 재원으로 한국연구재단의 지원을 받아 수행되었습니다. (RS-2024-00351313/NRF2021R1I1A2053285)

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