Journal of Digestive Cancer Research

  • 제12권2호
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  • Pages.53-67
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  • 2024
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  • 2950-9394(pISSN)
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  • 2950-9505(eISSN)
대한소화기암연구학회 (Korean Society of Gastrointestinal Cancer Research)
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Dietary Calcium Intake and Colorectal Adenoma in Men and Women with Low Calcium Intake

  • Jioh Kang (Department of Food and Nutrition, College of Human Ecology, Seoul National University) ;
  • Sang Hoon Kim (Division of Gastroenterology, Department of Internal Medicine, Chung-Ang University Gwangmyeong Hospital) ;
  • Joowon Chung (Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University School of Medicine) ;
  • Dong Hyun Kim (Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School) ;
  • Min Kyu Jung (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyungpook National University Hospital) ;
  • Seun Ja Park (Department of Internal Medicine, Kosin University College of Medicine) ;
  • Hoon Jai Chun (Department of Internal Medicine, Institute of Gastrointestinal Medical Instrument Research, Korea University College of Medicine) ;
  • Yun Jeong Lim (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine) ;
  • Hyun Jeong Cho (Department of Food and Nutrition, College of Human Ecology, Seoul National University) ;
  • Jung Eun Lee (Department of Food and Nutrition, College of Human Ecology, Seoul National University)
  • 투고 : 2024.08.09
  • 심사 : 2024.08.15
  • 발행 : 2024.08.20
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초록

Backgrounds/Aims: Calcium is a preventive factor for colorectal cancer, which develops from colorectal adenoma. This study aimed to investigate the association between dietary calcium intake and prevalence of colorectal adenoma among Korean adults. Methods: Overall, 612 participants aged ≥ 20 years who underwent gastrointestinal endoscopy at 8 medical centers from 2021 to 2023 were included. Dietary calcium intake was assessed using a food frequency questionnaire and was energy-adjusted using the residual model. Multivariate logistic regression models were used to calculate for the odds ratios (ORs) and 95% confidence intervals (CIs). The associations between dietary calcium intake and colorectal adenoma prevalence were also assessed according to the anatomic subsites and adenoma status (advanced or nonadvanced). Results: Among the 612 participants, 269 were diagnosed with colorectal adenoma (170 men and 99 women). With respect to the gender-specific association, low dietary calcium intake was associated with higher prevalence of colorectal adenoma among men (ORs [95% CIs]: 2.13 [0.50-9.00] for < 250 mg/day; 3.53 [1.06-11.76], 250 to < 350 mg/day; and 1.84 [0.63-5.35], 350 to < 650 mg/day, compared to ≥ 650 mg/day of dietary calcium [p for trend = 0.07]). Similar association was observed among women, but neither the association nor trend was statistically significant (p for trend = 0.59). These inverse associations remained similar for distal colon/rectal adenoma among women and advanced adenoma among men. Conclusions: Low dietary calcium intake was associated with high colorectal adenoma prevalence, particularly among men. Given the limited number of studies among Asian populations, our findings should be replicated in other Asian groups.

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과제정보

We thank all the participants who took part in this study.

참고문헌

  1. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021;71:209-249. https://doi.org/10.3322/caac.21660 
  2. Kang MJ, Jung KW, Bang SH, et al. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2020. Cancer Res Treat 2023;55:385-399. https://doi.org/10.4143/crt.2023.447 
  3. Nguyen LH, Goel A, Chung DC. Pathways of colorectal carcinogenesis. Gastroenterology 2020;158:291-302. https://doi.org/10.1053/j.gastro.2019.08.059 
  4. Januszewicz W, Fitzgerald RC. Early detection and therapeutics. Mol Oncol 2019;13:599-613. https://doi.org/10.1002/1878-0261.12458 
  5. Newmark HL, Wargovich MJ, Bruce WR. Colon cancer and dietary fat, phosphate, and calcium: a hypothesis. J Natl Cancer Inst 1984;72:1323-1325. https://doi.org/10.1093/jnci/72.6.1323 
  6. Lamprecht SA, Lipkin M. Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms. Nat Rev Cancer 2003;3:601-614. https://doi.org/10.1038/nrc1144 
  7. World Cancer Research Fund/American Institute for Cancer Research. Diet, nutrition, physical activity and colorectal cancer. 2018. https://www.wcrf.org/wp-content/uploads/2021/02/Colorectal-cancer-report.pdf (accessed July 21, 2024) 
  8. Keum N, Lee DH, Greenwood DC, Zhang X, Giovannucci EL. Calcium intake and colorectal adenoma risk: dose-response meta-analysis of prospective observational studies. Int J Cancer 2015;136:1680-1687. https://doi.org/10.1002/ijc.29164 
  9. Martinez ME, Marshall JR, Sampliner R, Wilkinson J, Alberts DS. Calcium, vitamin D, and risk of adenoma recurrence (United States). Cancer Causes Control 2002;13:213-220. https://doi.org/10.1023/a:1015032215779 
  10. Lieberman DA, Prindiville S, Weiss DG, Willett W. Risk factors for advanced colonic neoplasia and hyperplastic polyps in asymptomatic individuals. JAMA 2003;290:2959-2967. https://doi.org/10.1001/jama.290.22.2959 
  11. Oh K, Willett WC, Wu K, Fuchs CS, Giovannucci EL. Calcium and vitamin D intakes in relation to risk of distal colorectal adenoma in women. Am J Epidemiol 2007;165:1178-1186. https://doi.org/10.1093/aje/kwm026 
  12. Peters U, Chatterjee N, Mcglynn KA, et al. Calcium intake and colorectal adenoma in a US colorectal cancer early detection program. Am J Clin Nutr 2004;80:1358-1365. https://doi.org/10.1093/ajcn/80.5.1358 
  13. Hartman TJ, Albert PS, Snyder K, et al. The association of calcium and vitamin D with risk of colorectal adenomas. J Nutr 2005;135:252-259. https://doi.org/10.1093/jn/135.2.252 
  14. Massa J, Cho E, Orav EJ, Willett WC, Wu K, Giovannucci EL. Total calcium intake and colorectal adenoma in young women. Cancer Causes Control 2014;25:451-460. https://doi.org/10.1007/s10552-014-0347-9 
  15. Kesse E, Boutron-Ruault MC, Norat T, Riboli E, Clavel-Chapelon F. Dietary calcium, phosphorus, vitamin D, dairy products and the risk of colorectal adenoma and cancer among French women of the E3N-EPIC prospective study. Int J Cancer 2005;117:137-144. https://doi.org/10.1002/ijc.21148 
  16. Balk EM, Adam GP, Langberg VN, et al. Global dietary calcium intake among adults: a systematic review. Osteoporos Int 2017;28:3315-3324. https://doi.org/10.1007/s00198-017-4230-x 
  17. Yamaji T, Iwasaki M, Sasazuki S, Sakamoto H, Yoshida T, Tsugane S. Association between plasma 25-hydroxyvitamin D and colorectal adenoma according to dietary calcium intake and vitamin D receptor polymorphism. Am J Epidemiol 2012;175:236-244. https://doi.org/10.1093/aje/kwr295 
  18. Seol JE, Cho CH, Kim SH, Lee JE. Total and dietary calcium intake and colorectal adenoma in Korean adults. J Cancer Prev 2015;20:153-158. https://doi.org/10.15430/jcp.2015.20.2.153 
  19. Nagata C, Shimizu H, Kametani M, Takeyama N, Ohnuma T, Matsushita S. Diet and colorectal adenoma in Japanese males and females. Dis Colon Rectum 2001;44:105-111. https://doi.org/10.1007/bf02234831 
  20. Ahn Y, Kwon E, Shim JE, et al. Validation and reproducibility of food frequency questionnaire for Korean genome epidemiologic study. Eur J Clin Nutr 2007;61:1435-1441. https://doi.org/10.1038/sj.ejcn.1602657 
  21. National Institute of Agricultural Science. Korean Food Composition Table. Rural Development Administration, 2011. 
  22. Ainsworth BE, Haskell WL, Herrmann SD, et al. 2011 Compendium of Physical Activities: a second update of codes and MET values. Med Sci Sports Exerc 2011;43:1575-1581. https://doi.org/10.1249/MSS.0b013e31821ece12 
  23. Willett WC, Howe GR, Kushi LH. Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 1997;65:1220S-1228S; discussion 1229S-1231S. https://doi.org/10.1093/ajcn/65.4.1220S 
  24. Zhang X, Keum N, Wu K, et al. Calcium intake and colorectal cancer risk: results from the nurses' health study and health professionals follow-up study. Int J Cancer 2016;139:2232-2242. https://doi.org/10.1002/ijc.30293 
  25. Mccullough ML, Robertson AS, Rodriguez C, et al. Calcium, vitamin D, dairy products, and risk of colorectal cancer in the Cancer Prevention Study II Nutrition Cohort (United States). Cancer Causes Control 2003;14:1-12. https://doi.org/10.1023/a:1022591007673 
  26. Flood A, Peters U, Chatterjee N, Lacey JV Jr, Schairer C, Schatzkin A. Calcium from diet and supplements is associated with reduced risk of colorectal cancer in a prospective cohort of women. Cancer Epidemiol Biomarkers Prev 2005;14:126-132. https://doi.org/10.1158/1055-9965.126.14.1 
  27. Bullamore JR, Wilkinson R, Gallagher JC, Nordin BE, Marshall DH. Effect of age on calcium absorption. Lancet 1970;2:535-537. https://doi.org/10.1016/s0140-6736(70)91344-9 
  28. Wu K, Willett WC, Fuchs CS, Colditz GA, Giovannucci EL. Calcium intake and risk of colon cancer in women and men. J Natl Cancer Inst 2002;94:437-446. https://doi.org/10.1093/jnci/94.6.437 
  29. Chakrabarty S, Radjendirane V, Appelman H, Varani J. Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-catenin/TCF activation. Cancer Res 2003;63:67-71.