Journal of Dental Anesthesia and Pain Medicine

  • 제24권5호
  • /
  • Pages.305-318
  • /
  • 2024
  • /
  • 2383-9309(pISSN)
  • /
  • 2383-9317(eISSN)
대한치과마취과학회 (The Korean Dental Society of Anesthsiology)
권호 표지
DOI QR코드

DOI QR Code

Analgesic efficiency of dexketoprofen trometamol in third molar surgery: a systematic review and meta-analysis

  • Bishwa Prakash Bhattarai (Department of Oral Biology, Faculty of Dentistry, University of Oslo) ;
  • Diane Isabel Selvido (Walailak University International College of Dentistry, Walailak University) ;
  • Dinesh Rokaya (Clinical Sciences Department, College of Dentistry, Ajman University)
  • 투고 : 2024.07.02
  • 심사 : 2024.09.10
  • 발행 : 2024.10.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This study aims to compare the analgesic efficacy of dexketoprofen trometamol (DT) with other analgesic drugs for pain relief after third molar surgery. The PubMed, Scopus, and Web of Science databases were searched to identify randomized controlled trials comparing DT with other analgesics for third molar surgery. The outcome measures were the sum of pain intensity differences (SPID), total pain relief (TOTPAR) at the 6th and 8th postoperative hours, time to rescue medication, and tolerability. In total, four studies met our inclusion criteria. A total of 660 third molar surgeries were performed: 365 in the DT group and 295 in the active control group. Compared to other analgesics, DT produced significantly better pain relief at the 6th postoperative hour: SPID (MD, 0.33; P = 0.01) and TOTPAR (MD, 0.41; P = 0.02). However, there were no statistically significant differences in the efficiency of pain relief at the 8th postoperative hour, time to rescue medication, or tolerability. Overall, a 25 mg dose produced the best results for pain relief. In conclusion, DT (25 mg) is a viable alternative to contemporary analgesics for pain relief after third molar surgery, particularly during the early postoperative period.

키워드

참고문헌

  1. Cho H, Lynham AJ, Hsu E. Postoperative interventions to reduce inflammatory complications after third molar surgery: review of the current evidence. Aust Dent J 2017; 62: 412-9. 
  2. Ozturk AA, Kiyan HT. Treatment of oxidative stress-induced pain and inflammation with dexketoprofen trometamol loaded different molecular weight chitosan nanoparticles: formulation, characterization and anti-inflammatory activity by using in vivo HET-CAM assay. Microvasc Res 2020; 128: 103961. 
  3. Hanna M, Moon JY. A review of dexketoprofen trometamol in acute pain. Curr Med Res Opin 2019; 35: 189-202. 
  4. Mauleon D, Artigas R, Garcia ML, Carganico G. Preclinical and clinical development of dexketoprofen. Drugs 1996; 52(Suppl 5): 24-46. 
  5. Sweetman BJ. Development and use of the quick acting chiral NSAID dexketoprofen trometamol (keral). Acute Pain 2003; 4: 109-15. 
  6. Kesimci E, Gumus T, Izdes S, Sen P, Kanbak O. Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients. Agri 2011; 23: 153-9. 
  7. Moore RA, Barden J. Systematic review of dexketoprofen in acute and chronic pain. BMC Clin Pharmacol 2008; 8: 11. 
  8. Bagan JV, Lopez Arranz JS, Valencia E, Santamaria J, Eguidazu I, Horas M et al. Clinical comparison of dexketoprofen trometamol and dipyrone in postoperative dental pain. J Clin Pharmacol 1998; 38(Suppl 1): 55S-64S. 
  9. Erdil A, Akbulut N, Altan A, Demirsoy MS. Comparison of the effect of therapeutic elastic bandage, submucosal dexamethasone, or dexketoprofen trometamol on inflammatory symptoms and quality of life following third molar surgery: a randomized clinical trial. Clin Oral Investig 2021; 25: 1849-57. 
  10. Eroglu CN, Durmus E, Kiresi D. Effect of low-dose dexketoprofen trometamol and paracetamol on postoperative complications after impacted third molar surgery on healthy volunteers: a pilot study. Med Oral Patol Oral Cir Bucal 2014; 19: e622-e7. 
  11. McGurk M, Robinson P, Rajayogeswaran V, De Luca M, Casini A, Artigas R, et al. Clinical comparison of dexketoprofen trometamol, ketoprofen, and placebo in dental pain. J Clin Pharmacol 1998; 38(Suppl 1): 46S-54S. 
  12. Sterne JAC, Savovic J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 2019; 366: l4898. 
  13. McGuinness LA, Higgins JPT. Risk-of-bias VISualization (robvis): an R package and Shiny web app for visualizing risk-of-bias assessments. Res Synth Methods 2021; 12: 55-61. 
  14. Brennan SE, Johnston RV. Research note: interpreting findings of a systematic review using GRADE methods. J Physiother 2023; 69: 198-202. 
  15. GRADEpro GDT: GRADEpro Guideline Development Tool [Software]. McMaster University and Evidence Prime, 2024. 
  16. Jackson ID, Heidemann BH, Wilson J, Power I, Brown RD. Double-blind, randomized, placebo-controlled trial comparing rofecoxib with dexketoprofen trometamol in surgical dentistry. Br J Anaesth 2004; 92: 675-80. 
  17. Moore RA, Gay-Escoda C, Figueiredo R, Toth-Bagi Z, Dietrich T, Milleri S, et al. Dexketoprofen/tramadol: randomised double-blind trial and confirmation of empirical theory of combination analgesics in acute pain. J Headache Pain 2015; 16: 541. 
  18. Jimenez-Martinez E, Gasco-Garcia C, Arrieta-Blanco JJ, Gomez del Torno J, Bartolome Villar B. Study of the analgesic efficacy of dexketoprofen trometamol 25mg. vs. ibuprofen 600mg. after their administration in patients subjected to oral surgery. Med Oral 2004; 9: 138-48. 
  19. Kuczynska J, Pawlak A, Nieradko-Iwanicka B. The comparison of dexketoprofen and other painkilling medications (review from 2018 to 2021). Biomed Pharmacother 2022; 149: 112819. 
  20. Barbanoj MJ, Antonijoan RM, Gich I. Clinical pharmacokinetics of dexketoprofen. Clin Pharmacokinet 2001; 40: 245-62. 
  21. Esparza-Villalpando V, Chavarria-Bolanos D, Gordillo-Moscoso A, Masuoka-Ito D, Martinez-Rider R, Isiordia-Espinoza M, et al. Comparison of the analgesic efficacy of preoperative/postoperative oral dexketoprofen trometamol in third molar surgery: a randomized clinical trial. J Craniomaxillofac Surg 2016; 44: 1350-5. 
  22. Esparza-Villalpando V, Pozos-Guillen A, Masuoka-Ito D, Gaitan-Fonseca C, Chavarria-Bolanos D. Analgesic efficacy of preoperative dexketoprofen trometamol: a systematic review and meta-analysis. Drug Dev Res 2018; 79: 47-57. 
  23. Zippel H, Wagenitz A. Comparison of the efficacy and safety of intravenously administered dexketoprofen trometamol and ketoprofen in the management of pain after orthopaedic surgery: a multicentre, double-blind, randomised, parallel-group clinical trial. Clin Drug Investig 2006; 26: 517-28. 
  24. Cooper SA, Reynolds DC, Reynolds B, Hersh EV. Analgesic efficacy and safety of (R)-ketoprofen in postoperative dental pain. J Clin Pharmacol 1998; 38(Suppl 2): 11S-18S. 
  25. Gay C, Planas E, Donado M, Martinez JM, Artigas R, Torres F, et al. Analgesic efficacy of low doses of dexketoprofen in the dental pain model: a randomised, double-blind, placebo-controlled study. Clin Drug Investig 1996; 11: 320-30. 
  26. Olmez S, Donmez S, Aslan M, Karadas S, Yavuz A. Esophagitis due to dexketoprofen trometamol: a rare case report. Wien Klin Wochenschr 2015; 127: 399-401. 
  27. Kayipmaz AE, Giray TA, Tasci SS, Tasci SS, Kavalci C, Kocalar UG. Acute dystonic reaction due to dexketoprofen trometamol. J Pak Med Assoc 2015: 65: 1231-2. 
  28. Kilic M, Tuylu BA. An in vitro investigation of genotoxic effects of dexketoprofen trometamol on healthy human lymphocytes. Drug Chem Toxicol 2020; 43: 174-81.