Design & Manufacturing

Korean Society of Die & Mold Engineering (한국금형공학회)
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Analysis of the Effect of Micro-groove Patterns on Osseointegration using Pulsed Laser Processing

펄스 레이저 가공에 의한 마이크로 그루브 패턴이 골 세포 유착에 미치는 영향 분석

  • Seok-Jae Ha (Department of Automotive Engineering, Dong-Seoul University) ;
  • Si-Myung Sung (Department of Mechanical Engineering, Inha University) ;
  • Hye-Jin Kim (Department of Mechanical Engineering, Inha University)
  • 하석재 (동서울대학교 미래자동차학과) ;
  • 성시명 (인하대학교 기계공학과) ;
  • 김혜진 (인하대학교 기계공학과)
  • Received : 2024.08.28
  • Accepted : 2024.09.30
  • Published : 2024.09.30
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Abstract

As the demand for biomaterials and medical devices increases due to advancements in medical technology and the rising average lifespan of the population, the importance of surface treatment technology for biometallic materials used in orthopedic implants is highlighted. Achieving stable mechanical attachment between the implant and human bone, specifically bone cell adhesion, is crucial. Without proper adhesion, issues such as inflammation and reduced load-bearing capacity can occur, leading to the need for implant reimplantation. Therefore, this paper focuses on creating a micro-groove pattern using a pulsed nanosecond laser on the surface of a titanium alloy (Ti6Al4V), a biometallic material, to promote cell adhesion. To evaluate the effectiveness of the pattern in enhancing cell adhesion, MG-63 osteoblasts were cultured on the micro-groove patterned surface, and their adhesion and morphological changes were analyzed. This study confirms the potential of laser processing as a surface treatment method for biometallic materials.

Keywords

Acknowledgement

본 연구는 2023년도 동서울대학교 연구지원센터의 지원에 의하여 연구되었음.

References

  1. Kiradzhiyska, Denitsa D, and Rositsa D Mantcheva. "Overview of Biocompatible Materials and Their Use in Medicine." Folia medica vol. 61, 1, pp. 34-40, 2019.
  2. M. Geetha, A.K. Singh, R. Asokamani, A.K. Gogia, "Ti based biomaterials, the ultimate choice for orthopaedic implants - A review", Progress in Materials Science, Volume 54, Issue 3, pp. 397-425, 2009.
  3. Kulkarni, Mukta, Mazare, Anca, Schmuki, Patrik, 'Biomaterial Surface Modification Of Titanium and Titanium Alloys for Medical Applications", Nanomedicine, pp. 111-136, 2014.
  4. N.S. Manam, W.S.W. Harun, D.N.A. Shri, S.A.C. Ghani, T. Kurniawan, M.H. Ismail, M.H.I. Ibrahim, "Study of corrosion in biocompatible metals for implants: A review", Journal of Alloys and Compounds, Vol. 701, pp. 698-715, 2017.
  5. Gao X., Fraulob M., Haiat G., "Biomechanical behaviours of the bone-implant interface: a review." Journal of the Royal Society, Interface vol. 16(156), 2019.
  6. Rasheed Sarvar, "Comparison of micro-holes produced by micro-EDM with laser machining", International Journal of Science and Modern Engineering, vol. 1(3), pp.14-18, 2013.
  7. Ozdemir M., H. Sadikoglu, "A new and emerging technology: Laser-induced surface modification of polymers", Trends in Food Science and Technology 9, pp. 159-167, 1998.
  8. Biggs, M. J., Richards, R. G., McFarlane, S., Wilkinson, C. D., Oreffo, R. O., Dalby, M. J, "Adhesion formation of primary human osteoblasts and the functional response of mesenchymal stem cells to 330nm deep microgrooves", Journal of the Royal Society, Interface, vol. 5(27), pp. 1231-1242, 2008.
  9. Cipriano, A. F., De Howitt, N., Gott, S. C., Miller, C., Rao, M. P., Liu, H, "Bone marrow stromal cell adhesion and morphology on micro- and sub-micropatterned titanium. Journal of biomedical nanotechnology", vol. 10(4), pp. 660-668, 2014.
  10. J. R. Park, H. J. Kim, J. Y. Park, S. M. Sung, S. Y. Hong, and K. H. Song, "A study on the injection mold with superhydrophobic surface properties using nanosecond laser machining", Design & Manufacturing, Vol.17, No.33, pp.48-54, 2023.
  11. T. H. Park, H. S. Lee, H. J. Lee, and T. Y. Hwang, "Controlled surface functionalities of metals using femtosecond laser-induced nano- and micro scale surface structures", Design & Manufacturing, Vol.17, No.02, pp.55-61, 2023.