동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제35권3호
  • /
  • Pages.257-267
  • /
  • 2024
  • /
  • 1226-6396(pISSN)
  • /
  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
권호 표지
DOI QR코드

DOI QR Code

파킨슨병으로 인한 우울증의 한의 임상연구 고찰

A Review of Clinical Studies on Depression Caused by Parkinson's Disease in Traditional Korean Medicine

  • 김정원 (우석대학교 한의과대학) ;
  • 남태광 (우석대학교 한의과대학) ;
  • 김안나 (한국한의학연구원 한의약데이터부) ;
  • 오용택 (우석대학교 한의과대학 진단학교실)
  • Jeongwon Kim (College of Korean Medicine, Woosuk University) ;
  • Taegwang Nam (College of Korean Medicine, Woosuk University) ;
  • Anna Kim (KM Data Division, Korea Institute of Oriental Medicine) ;
  • Yongtaek Oh (Department of Diagnostics, College of Korean Medicine, Woosuk University)
  • 투고 : 2024.08.22
  • 심사 : 2024.09.23
  • 발행 : 2024.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: Parkinson's disease is a degenerative neurological disorder caused by dopamine neuron damage, leading to various motor and non-motor symptoms, including depression. While several clinical studies on Traditional Korean Medicine (TKM) have addressed this issue, no comprehensive review has been conducted. This study aimed to summarize and analyze TKM treatments for depression associated with Parkinson's disease. Methods: This study reviewed research focused on treatment of Parkinson's-related depression, particularly examining traditional therapies such as acupuncture and herbal medicine. Data on treatment methods were analyzed to compare approaches of control and experimental groups. Specific use of acupuncture points and other TKM treatments was analyzed. Results: Out of 57 studies, 17 involving 649 participants were selected. Various treatment methods were evaluated, primarily using the Unified Parkinson's Disease Rating Scale (UPDRS). Studies predominantly focused on acupuncture targeting specific points (such as LI 4, GB 20, and ST 36) and the use of various herbal medicine combinations. Conclusions: Of the 17 studies, 13 focused on effects of acupuncture, suggesting that acupuncture might play a significant role in alleviating depression associated with Parkinson's disease. Specifically, the use of acupuncture points such as LI 4, GB 20, and ST 36 showed potential therapeutic effects. Additionally, 13 studies demonstrated that TKM could significantly alleviate depression, indicating the potential for an integrative approach combining Eastern and Western therapies. Herbal medicine and Qigong dance therapy also showed promising effects in improving depression.

키워드

과제정보

This work was supported by the Korea Institute of Oriental Medicine (grant number KSN1923111) and the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. RS-2023-00254007).

참고문헌

  1. Ha JY, Lee SH, Yin CS, Park SM, Kang JW, Chang DI, Lee YH. The Effect of Manual Acupuncture Therapy on Symptoms of the Patients with Idiopathic Parkinson's Disease. J Korean Med. 2003;24(3):172-83.
  2. Lee JH, Lee MS, Son YH, Kim KH, Kim JS. The frequency of depression and its effects in idiopathic Parkinson's disease. J Korean Neurol Assoc. 1995 Sep;13(3):574-83.
  3. Lee SY, Kim MY, Kim YJ, Choi WW, Min IK, Seong JJ, Hong JW, Na BJ, Jeong WS, Moon SG, Joe GH, Kim YS. Report on the Case Study of Parkinson's Syndrome Patients Visited to Korean Oriental Hospital. Korean Journal of Joongpoong. 2007 Dec;8(1):34-39.
  4. Statistics on Diseases of Public Interest, HIRA Big Data Open Portal. 2024. Available from: https://opendata.hira.or.kr/op/opc/olapMfrnIntrsIlnsInfoTab1.do
  5. Li Q, Wu C, Wang X, Li Z, Hao X, Zhao L, Li M, Zhu M. Effect of acupuncture for non-motor symptoms in patients with Parkinson's disease: A systematic review and meta-analysis. Front Aging Neurosci. 2022 Oct. DOI: 10.3389/fnagi.2022.995850
  6. Park SW. A carbon quantum dot-based fluorescent biosensor for sensitive and selective detection of levodopa. Inje University General Graduate School; 2021. DOI: 10.1016/j.aca.2021.338513
  7. Yang DH, Lee GY, Sin HS, Joe SH, Yim CS, Lim JH, Yoon SH, Lee H, Kang MJ. A Study on the Effect of Acupuncture on the Side Effects of Gastrointestinal System in Levodopa Drugs - Patients with idiopathic Parkinson's Disease. J Acupunct Res. 2010;27(6):11-21.
  8. Faingold CL. Electrical stimulation therapies for CNS disorders and pain are mediated by competition between different neuronal networks in the brain. Med Hypotheses. 2008 Nov;71(5):668-81. DOI: 10.1016/j.mehy.2008.06.030
  9. Chen FP, Chang CM, Shiu JH, Chiu JH, Wu TP, Yang JL, Kung YY, Chen FJ, Chern CM, Hwang SJ. A clinical study of integrating acupuncture and Western medicine in treating patients with Parkinson's disease. Am J Chin Med. 2015;43(3):407-23. DOI: 10.1142/S0192415X15500263
  10. Yeo S, van den Noort M, Bosch P, Lim S. A study of the effects of 8-week acupuncture treatment on patients with Parkinson's disease. Medicine (Baltimore). 2018 Dec; 97(50):e13434. DOI: 10.1097/MD.0000000000013434
  11. Iseki C, Furuta T, Suzuki M, Koyama S, Suzuki K, Suzuki T, Kaneko A, Mitsuma T. Acupuncture alleviated the nonmotor symptoms of Parkinson's disease including pain, depression, and autonomic symptoms. Case Rep Neurol Med. 2014;2014:953109. DOI: 10.1155/2014/953109
  12. Kong KH, Ng HL, Li W, Ng DW, Tan SI, Tay KY, Au WL, Tan LCS. Acupuncture in the treatment of fatigue in Parkinson's disease: A pilot, randomized, controlled, study. Brain Behav. 2017 Dec;8(1):e00897. DOI: 10.1002/brb3.897
  13. Shulman LM, Wen X, Weiner WJ, Bateman D, Minagar A, Duncan R, Konefal J. Acupuncture therapy for the symptoms of Parkinson's disease. Mov Disord. 2002 Jul; 17(4):799-802. DOI: 10.1002/mds.10134
  14. Wang F, Sun L, Zhang XZ, Jia J, Liu Z, Huang XY, Yu SY, Zuo LJ, Cao CJ, Wang XM, Zhang W. Effect and potential mechanism of electroacupuncture add-on treatment in patients with Parkinson's disease. Evid Based Complement Alternat Med. 2015;2015:692795. DOI: 10.1155/2015/692795
  15. Jang JH, Kim J, Kwon O, Jung SY, Lee HJ, Cho SY, et al. Effectiveness and Therapeutic Mechanism of Pharmacopuncture for Pain in Parkinson's Disease: A Study Protocol for a Pilot Pragmatic Randomized, Assessor-Blinded, Usual Care-Controlled, Three-Arm Parallel Trial. International Journal of Environmental Research and Public Health. 2023 Feb;20(3):1776. DOI: 10.3390/ijerph20031776
  16. Cho SY, Shim SR, Rhee HY, Park HJ, Jung WS, Moon SK, Park JM, Ko CN, Cho KH, Park SU. Effectiveness of acupuncture and bee venom acupuncture in idiopathic Parkinson's disease. Parkinsonism Relat Disord. 2012 Sep;18(8):948-52. DOI: 10.1016/j.parkreldis.2012.04.030
  17. Kang DH, Kim JY, Park YC, Yoo HR, Jung IC. Efficacy and safety of a combination of emotional freedom technique with acupuncture versus acupuncture alone to treat psychiatric symptoms in Parkinson's disease: A protocol for a randomized, assessor-blind, parallel-group clinical trial. Medicine (Baltimore). 2023 May;102(21):e33714. DOI: 10.1097/MD.0000000000033714
  18. Cho SY, Lee YE, Doo KH, Lee JH, Jung WS, Moon SK, Park JM, Ko CN, Kim H, Rhee HY, Park HJ, Park SU. Efficacy of combined treatment with acupuncture and bee venom acupuncture as an adjunctive treatment for Parkinson's disease. J Altern Complement Med. 2018 Jan;24(1):25-32. DOI: 10.1089/acm.2016.0250
  19. Cristian A, Katz M, Cutrone E, Walker RH. Evaluation of acupuncture in the treatment of Parkinson's disease: a double-blind pilot study. Mov Disord. 2005 Sep;20(9): 1185-8. DOI: 10.1002/mds.20503
  20. Xu Y, Cai X, Qu S, Zhang J, Zhang Z, Yao Z, Huang Y, Zhong Z. Madopar combined with acupuncture improves motor and non-motor symptoms in Parkinson's disease patients: A multicenter randomized controlled trial. Eur J Integr Med. 2020;34:101049. DOI: https://doi.org/10.1016/j.eujim.2019.101049
  21. Wu C, Zhao L, Guo Y, Hao X, Fan Y, Wu P, Han J, Li Q, Wang X, Wang Q, Luo X, Zhu M. Moxibustion treatment for Parkinson's disease: study protocol for a randomized controlled trial. BMC Complement Med Ther. 2023 Jun; 23(1):193. DOI: 10.1186/s12906-023-03995-w
  22. Roh MY, Lee JH, Han YH, Lim JT. A case report in which the non-motile symptoms evaluated by the Non-Motor Symptom Scale (NMSS) in a patient with secondary Parkinson's disease, which is presumed to be Lewy body dementia, were improved with a combination of herbal medicine and acupuncture. J Korean Acad Orient Med. 2021;42(5):833-45. DOI: https://doi.org/10.22246/jikm.2021.42.5.833
  23. Kim YJ, Kim JH, Lee BY, Yang SB, Joe SY, Park SW, Park JM, Go CN. A case of oriental medicine trial in a patient with weak Parkinson's syndrome. J Korean Acad Orient Med. 2016;37(2):381-88.
  24. Doo KH, Lee JH, Cho SY, Jung WS, Moon SK, Park JM, Ko CN, Kim H, Park HJ, Park SU. A prospective open-label study of combined treatment for idiopathic Parkinson's disease using acupuncture and bee venom acupuncture as an adjunctive treatment. J Altern Complement Med. 2015 Oct;21(10):598-603. DOI: 10.1089/acm.2015.0078
  25. Lee HJ, Kim SY, Chae Y, Kim MY, Yin C, Jung WS, Cho KH, Kim SN, Park HJ, Lee H. Turo (Qi Dance) Program for Parkinson's Disease Patients: Randomized, Assessor Blind, Waiting-List Control, Partial Crossover Study. Explore (NY). 2018 May-Jun;14(3):216-23. DOI: 10.1016/j.explore.2017.11.002
  26. Filshie Jacqueline, White Adrian, Cummings Mike. Medical Acupuncture: A Western Scientific Approach. 2nd rev. Edinburgh: Elsevier. 2016:734.
  27. Kang HS, Kim JY, Lee JH, Seong YW. Two trials applying a combination of acupuncture and meditation for depressed patients who complain of physical symptoms as their main symptoms. J Assoc Neuropsychiatry Dong. 2008;19(2):241-50.
  28. Korean Medical University and the Graduate School of Oriental Medicine Compilation Committee for Contribution to Transfusion Textbooks. Transfusion of Transfusion (1). JEONGDAM. 2020. 760.
  29. Korean Medical University and the Graduate School of Oriental Medicine Compilation Committee for Contribution to Transfusion Textbooks. Transfusion of Transfusion (2). JEONGDAM. 2020. 756.
  30. Terawaki T, Ikarashi Y, Sekiguchi K, Nakai Y, Kase Y. Partial agonistic effect of Yokukansan on human recombinant serotonin 1A receptors expressed in the membranes of Chinese hamster ovary cells. J Ethnopharmacol. 2021; 127:306-12. DOI: 10.1016/j.jep.2009.11.003
  31. Egasira N, Iwasaki K, Ishibashi A, et al. Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT) 2A receptors in the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:1516-20. DOI: 10.1016/j.pnpbp.2008.05.010
  32. Lee HY, Park SJ, Jeong KS, Son YJ, Jeong HS, Park DI, Son NW. The effect of Yanggyeoksanhwatang on nerve cell damage caused by ischemic damage to brain hippocampal tissue culture. J Korean Acad Orient Med. 2008; 29(1):231-42.
  33. Jang YS. Production of endogenous neurons in the brain after birth. Korean J Pediatr. 2005;48(8).
  34. He X, Ng MS, Choi KC, So WK. Effects of a 16-week dance intervention on the symptom cluster of fatiguesleep disturbance-depression and quality of life among patients with breast cancer undergoing adjuvant chemotherapy: A randomized controlled trial. Int J Nurs Stud. 2022;133:104317. DOI: 10.1016/j.ijnurstu.2022.104317
  35. Rios Romenets S, Anang J, Fereshtehnejad SM, Pelletier A, Postuma R. Tango for treatment of motor and non-motor manifestations in Parkinson's disease: a randomized control study. Complement Ther Med. 2015;23(2):175-84. DOI: 10.1016/j.ctim.2015.01.015
  36. Michels K, Dubaz O, Hornthal E, Bega D. Dance Therapy as a psychotherapeutic movement intervention in Parkinson's disease. Complement Ther Med. 2018;40:248-52. DOI: 10.1016/j.ctim.2018.07.005