Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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A Study on the Development of Guideline for Co-Administration of Four Types of Herbal Medicine and Escitalopram

항우울제와 한약제제의 병용투여지침 개발-에스시탈로프람과 보험 4종 한약제제를 중심으로

  • Do-Eun Lee (Department of Korean Neuropsychiatry, College of Korean Medicine, Wonkwang University) ;
  • Kyeong Jin Ko (Department of Korean Neuropsychiatry, College of Korean Medicine, Wonkwang University) ;
  • Young-Woo Kim (Department of Herbal Formula, College of Korean Medicine, Dongguk University) ;
  • Choon Ok Kim (Department of Clinical Phamacology, Severance Hospital, Yonsei University Health System) ;
  • Hyung Won Kang (Department of Korean Neuropsychiatry, College of Korean Medicine, Wonkwang University)
  • 이도은 (원광대학교 한의과대학 한방신경정신과학교실) ;
  • 고경진 (원광대학교 한의과대학 한방신경정신과학교실) ;
  • 김영우 (동국대학교 한의과대학 방제학교실) ;
  • 김춘옥 (연세대학교 세브란스병원 임상약리학교실) ;
  • 강형원 (원광대학교 한의과대학 한방신경정신과학교실)
  • Received : 2024.09.21
  • Accepted : 2024.09.25
  • Published : 2024.09.30
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Abstract

Objectives: To develop guidelines for concomitant use of four herbal medicines (Gamisoyosan, Banhasasimtang, Ojeoksan, and Bojungikgitang) with escitalopram. Methods: A guideline development team was assembled and relevant prior research was systematically reviewed to gather evidence. The potential for drug interactions was evaluated by analyzing changes in pharmacokinetic parameters. Safety was assessed through the analysis of adverse drug reactions associated with combined use. Recommendations and concomitant administration guidelines were formulated through a consensus process. Results: No significant drug interactions were identified between the four herbal medicines and escitalopram, indicating no need for dosage adjustment of escitalopram. However, it is recommended to monitor potential adverse reactions during concurrent use. Conclusions: This study provides recommendations for combined use of four herbal medicines covered by domestic insurance combined with escitalopram. Further research on interactions between antidepressants and herbal medicine is necessary to refine and enhance concomitant administration guidelines.

Keywords

Acknowledgement

This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: RS-2020-KH093754).

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