대한약침학회지 (Journal of Pharmacopuncture)

  • 제27권3호
  • /
  • Pages.234-244
  • /
  • 2024
  • /
  • 2093-6966(pISSN)
  • /
  • 2234-6856(eISSN)
대한약침학회 (KOREAN PHARMACOPUNCTURE INSTITUTE)
권호 표지
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Anxiolytic and Antianhedonic-like Effects of Psidium guajava Leaf in Alcohol-Withdrawn Mice

  • Vanjarapu Harithadevi (Department of Pharmacology, Chalapathi Institute of Pharmaceutical Sciences) ;
  • Vijayapandi Pandy (Department of Pharmacology, Chalapathi Institute of Pharmaceutical Sciences)
  • 투고 : 2024.04.06
  • 심사 : 2024.07.08
  • 발행 : 2024.09.30
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초록

Objectives: Alcohol withdrawal syndrome manifests through a range of symptoms, including anxiety and anhedonia, significantly affecting the quality of life of those affected. This study investigates the potential therapeutic effects of the methanolic extract of Psidium guajava leaves (MPG) on anxiety and anhedonia in Swiss albino female mice undergoing alcohol withdrawal. Methods: Four groups of mice underwent alcohol withdrawal, with one group undergoing saline withdrawal as a control. On the test day, behavioral assessments were conducted to evaluate anxiety and anhedonia. Groups I and II received sodium carboxymethylcellulose, Group III received diazepam, and Groups IV and V received varying oral doses of MPG. Results: The results indicate significant anti-anhedonic and anxiolytic effects of MPG. These effects were observed through changes in parameters measured in the Open Field test, Elevated Plus Maze test, Marble Burying test, and Sucrose Preference test. Mice treated with MPG displayed reduced anxiety-like behaviors and increased sucrose preference compared to untreated mice undergoing alcohol withdrawal. Conclusion: These findings suggest that Psidium guajava leaf extract may have therapeutic potential in alleviating anxiety and anhedonia associated with alcohol withdrawal. The observed effects indicate that MPG could serve as a promising adjunct therapy for managing alcohol withdrawal symptoms, thereby enhancing the overall well-being of individuals undergoing alcohol cessation.

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과제정보

We express our sincere gratitude to DST-SERB for the research grant (No. CRG/2018/000813) for carrying out this project. We are thankful to Prof. Rama Rao N, the Principal, Chalapathi Institute of Pharmaceutical Sciences, and Sri YV Anjaneyulu, the president, Chalapathi Educational Society, Lam, Guntur for providing the necessary lab facilities to perform this study.

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