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Suspected Caroli Syndrome in a Dog and Cat: A Rare Case Report

  • Jeong Ha Lee (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Jeju National University) ;
  • Nohwon Park (Nowon Animal Medical Center) ;
  • Rayoung Heo (Nowon Animal Medical Center) ;
  • Myung-Chul Kim (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Jeju National University) ;
  • Youngmin Yun (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Jeju National University) ;
  • Woo-Jin Song (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Jeju National University)
  • Received : 2024.07.09
  • Accepted : 2024.08.14
  • Published : 2024.08.31

Abstract

Caroli syndrome (CS) is characterized by multiple intrahepatic biliary cysts which are continuous with the biliary tract. First case is a 1-year-old, Munchkin cat that presented with icterus. This patient was diagnosed with CS based on imaging and histopathology. With surgery and supportive care, the patient has been well managed. Second case is a 1-year-old, mixed breed dog that presented with anorexia and abdominal distention. This patient was suspected to have CS based on ultrasonography, and died after 7 days. Although unusual, CS could be considered as a differential diagnosis for young animals with hepatic cysts.

Keywords

Acknowledgement

This study was funded by the National Research Foundation (NRF) of Korea grant funded by the Korea government (MSIT) (RS-2023-00252033).

References

  1. Arnon R, Rosenberg HK, Suchy FJ. Caroli disease, Caroli syndrome, and congenital hepatic fibrosis. In: Murray K, Larson A, editors. Fibrocystic diseases of the liver. Totowa: Humana Press. 2010: 331-358.
  2. Buob S, Johnston AN, Webster CR. Portal hypertension: pathophysiology, diagnosis, and treatment. J Vet Intern Med 2011; 25: 169-186. https://doi.org/10.1111/j.1939-1676.2011.00691.x
  3. Cecco BS, Lorenzett MP, Henker LC, Bisol J, Soares AG, Trindade-Gerardi AB, et al. Caroli syndrome in a dog. Cienc Rural 2022; 52: e20210238.
  4. Desmet VJ. What is congenital hepatic fibrosis? Histopathology 1992; 20: 465-477. https://doi.org/10.1111/j.1365-2559.1992.tb01031.x
  5. Glavan C. Imaging findings and monitoring of a rare case of congenital intrahepatic bile duct ectasia (Caroli-like disease) and a pancreatic cyst in a 2-month-old cat. Vet Rec Case Rep 2022; 10: e450.
  6. Gorlinger S, Rothuizen J, Bunch S, van den Ingh TS. Congenital dilatation of the bile ducts (Caroli's disease) in young dogs. J Vet Intern Med 2003; 17: 28-32.
  7. Helgert ND, Sula MM. Caroli syndrome in a 6-year-old Rottweiler dog. J Comp Pathol 2019; 167: 1-5. https://doi.org/10.1016/j.jcpa.2018.11.004
  8. Jaffey JA. Canine hepatobiliary anatomy, physiology and congenital disorders. J Small Anim Pract 2022; 63: 95-103. https://doi.org/10.1111/jsap.13410
  9. Kerkar N, Norton K, Suchy FJ. The hepatic fibrocystic diseases. Clin Liver Dis 2006; 10: 55-71, v-vi. https://doi.org/10.1016/j.cld.2005.10.003
  10. Last RD, Hill JM, Roach M, Kaldenberg T. Congenital dilatation of the large and segmental intrahepatic bile ducts (Caroli's disease) in two Golden retriever littermates. J S Afr Vet Assoc 2006; 77: 210-214. https://doi.org/10.4102/jsava.v77i4.379
  11. Mabrut JY, Partensky C, Jaeck D, Oussoultzoglou E, Baulieux J, Boillot O, et al. Congenital intrahepatic bile duct dilatation is a potentially curable disease: long-term results of a multi-institutional study. Ann Surg 2007; 246: 236-245. https://doi.org/10.1097/SLA.0b013e3180f61abf
  12. Perricone G, Vanzulli A. Education and imaging. Hepatology: "central dot sign" of Caroli syndrome. J Gastroenterol Hepatol 2015; 30: 234.
  13. Roberts ML, Rine S, Lam A. Caroli's-type ductal plate malformation and a portosystemic shunt in a 4-month-old kitten. JFMS Open Rep 2018; 4: 2055116918812329.
  14. Serrano G, Mortier F, Bosseler L, Taylor O, Paepe D. Diagnosis of Caroli syndrome in a crossbreed dog. Vet Rec Case Rep 2018; 6: e000576.
  15. Yonem O, Bayraktar Y. Clinical characteristics of Caroli's syndrome. World J Gastroenterol 2007; 13: 1934-1937. https://doi.org/10.3748/wjg.v13.i13.1934