Korean Journal of Agricultural Science (농업과학연구)

Institute of Agricultural Science, CNU (충남대학교 농업과학연구소)
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Effect of cordycepin-enriched Cordyceps militaris L. extract powder on alcohol degradation and hepatoprotection in mice alcohol model

  • Ju-Hye Kim (Department of Bio-Environmental Chemistry, College of Agriculture and Life Science, Chungnam National University) ;
  • Heejin Park (Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT)) ;
  • Mun-Hyoung Bae (Functional Materials Research Team, Rpbio Research Institute, Rpbio Co., Ltd.) ;
  • Youngha Seo (Functional Materials Research Team, Rpbio Research Institute, Rpbio Co., Ltd.) ;
  • Eun-Young Gu (Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT)) ;
  • Taek-Keun Oh (Department of Bio-Environmental Chemistry, College of Agriculture and Life Science, Chungnam National University) ;
  • Byoung-Seok Lee (Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT))
  • Received : 2024.03.20
  • Accepted : 2024.05.02
  • Published : 2024.06.01
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Abstract

Cordyceps militaris L. (C. militaris) has been traditionally used as tonic medicine for metabolic syndrome. Cordycepin, has been reported with immunomodulatory, antitumor, and hepatoprotective effect, is the main extract from C. militaris. This study was conducted to evaluate the alcohol degradation and hepatoprotective effect of cordycepin-enriched C. militaris extract (CM) powder in chronic and binge ethanol (ethanol Lieber-DeCarli diet)-fed male C57BL/6 Mice. Cordycepin-enriched C. militaris extract powder was orally administered once daily at dose levels of 0, 125, 250, and 500 mg·kg-1·day-1 for 16 days. For evaluating alcohol degradation, ethanol concentration and alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity were measured in serum. Serum ethanol (EtOH) concentration was decreased at CM treated groups, and the activities of ADH and ALDH were increased dose-dependently at CM treated groups compare to EtOH model group. In clinical chemistry, the values of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were lower in CM treated groups than those in EtOH model group. Additionally, absolute and relative (to body weight) liver weights were statistically decreased in the CM treated groups compared to the EtOH model group. In conclusion, our study showed that cordycepin-enriched C. militaris extract powder exhibits hepatoprotective effect by upregulating the ADH and ALDH enzyme in an alcoholic liver disease model.

Keywords

Acknowledgement

본 연구는 안전성평가연구소(1711195885; B-S Lee)의 지원으로 수행되었습니다.

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