농업과학연구 (Korean Journal of Agricultural Science)

  • 제51권2호
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  • Pages.147-158
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  • 2024
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  • 2466-2402(pISSN)
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  • 2466-2410(eISSN)
충남대학교 농업과학연구소 (Institute of Agricultural Science, CNU)
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Evaluation of liver function using Cordyceps militaris extract powder in Sprague-Dawley rat with acute hepatic injury induced by dimethylnitrosamine

  • Heejin Park (Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT)) ;
  • Ju-Hye Kim (Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT)) ;
  • Mun-Hyoung Bae (Functional Materials Research Team, Rpbio Research Institute, Rpbio Co., Ltd.) ;
  • Youngha Seo (Functional Materials Research Team, Rpbio Research Institute, Rpbio Co., Ltd.) ;
  • Eun-Young Gu (Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT)) ;
  • Taek-Keun Oh (Department of Bio-Environmental Chemistry, College of Agriculture and Life Science, Chungnam National University) ;
  • Byoung-Seok Lee (Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT))
  • 투고 : 2024.03.20
  • 심사 : 2024.05.02
  • 발행 : 2024.06.01
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초록

Hepatic fibrosis refers to the scarring of liver tissue, often resulting from chronic liver injury or inflammation. It is characterized by excessive deposition of extracellular matrix proteins, impairing liver function and potentially progressing to cirrhosis if left untreated. To improve the liver functions, Cordyceps militaris, a species of parasitic fungus known for its medicinal properties, is used in the form of extract. It has been traditionally used in Chinese medicine to boost energy, improve stamina, and support overall health. In this study, we investigated the hepatoprotective effects of Cordyceps militaris extract powder in a liver injury model induced by hepatic fibrosis. Sprague-Dawley (SD) rats were administered Dimethylnitrosamine (DMN) to induce liver injury, and the hepatoprotective effects of Cordyceps militaris extract powder intake were assessed by comparing changes in liver enzyme levels and histological observations. Rats injected with DMN were orally administered Cordyceps militaris extract powder at doses of 0, 125, 250, and 500 mg·kg-1·day-1 for three weeks. After three weeks of treatment, no significant differences were observed in hematological, clinical chemical, organ weight, gross examination, or microscopic examination between the DMN-alone group and the Cordyceps militaris extract powder-treated group. In conclusion, hepatoprotective effects against DMN-induced liver injury in SD rats treated with Cordyceps militaris extract powder were not observed under this study condition.

키워드

과제정보

본 연구는 안전성평가연구소(NTIS No. 1711195885; B-S Lee)의 지원으로 수행되었습니다.

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