The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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What is Different about Recombinant Herpes Zoster Vaccine?

유전자 재조합 대상포진 백신 무엇이 다를까?

  • Seong Yeon Park (Department of Infectious Diseases, Dongguk University Ilsan Hospital, Dongguk University College of Medicine)
  • 박성연 (동국대학교 의과대학 동국대학교일산병원 감염내과)
  • Received : 2024.06.25
  • Accepted : 2024.07.29
  • Published : 2024.08.01
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Abstract

Herpes zoster (HZ) affects about one in three persons in their life time. Compared with the general population, older adults with immune senescence and individuals who are immunocompromised therapy are at increased risk for HZ, and its debilitating complications. To prevent HZ, two HZ vaccines, zoster vaccine live (ZVL) and recombinant zoster vaccine (RZV) are available. RZV is The Korean Society of Infectious Diseases revised guidelines for HZ vaccine in 2023, and recommended to vaccinate with RZV for adults ≥ aged 50 years and for severely immunocompromised adults aged ≥ 18 years. RZV is more effective for prevention of HZ than ZVL. RZV is nonreplicating and is thus safe in immunocompromised patients. RZV has clinically acceptable safety profile. This review will help clinicians update knowledge about RZV and identify eligible subjects who may benefit from HZ vaccinations.

Keywords

References

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