International Journal of Heart Failure

The Korean Society of Heart Failure (대한심부전학회)
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Vitamin D Deficiency in Patients Hospitalized for Heart Failure Living in the Tropics

  • Lucian Batista de Oliveira (Division of Endocrinology and Diabetes, Agamenon Magalhaes Hospital, University of Pernambuco (UPE), Faculty of Medical Sciences) ;
  • Mariana Andrade de Figueiredo Martins Siqueira (Division of Endocrinology and Diabetes, Agamenon Magalhaes Hospital, University of Pernambuco (UPE), Faculty of Medical Sciences) ;
  • Rafael Buarque de Macedo Gadelha (Division of Cardiology, Agamenon Magalhaes Hospital, University of Pernambuco (UPE), Faculty of Medical Sciences) ;
  • Jessica Garcia (Division of Cardiology, Agamenon Magalhaes Hospital, University of Pernambuco (UPE), Faculty of Medical Sciences) ;
  • Francisco Bandeira (Division of Endocrinology and Diabetes, Agamenon Magalhaes Hospital, University of Pernambuco (UPE), Faculty of Medical Sciences)
  • Received : 2023.04.25
  • Accepted : 2023.10.23
  • Published : 2024.04.30
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Abstract

Background and Objectives: Vitamin D, as a steroid hormone, has multiple effects on human body and its deficiency has been associated with an increased risk of heart failure (HF) and unfavorable outcomes. The present study investigated the prevalence of vitamin D deficiency (VDD) and its relationship with cardiometabolic parameters in patients hospitalized for HF living in the city of Recife (latitude 8° South). Methods: Analytical cross-sectional study, with men and women aged 40-64 years. The HF group was recruited during hospitalization due to decompensation. A matched control group was recruited from the general endocrine clinics. Vitamin D status was assessed by measuring serum 25-hydroxyvitamin D (25OHD), considering deficiency when 25OHD <20 ng/mL (<50 nmol/L). Results: A total of 243 patients were evaluated (HF group: 161, control group: 82). Lower serum 25OHD levels were observed in the HF group (25.2±9.4 vs. 30.0±7.7ng/mL; p<0.001), as well as a higher prevalence of VDD (27.3% vs. 9.8%; prevalence ratio, 2.80; 95% confidence interval, 1.38-5.67; p=0.002). In patients with HF, VDD was associated with diabetes mellitus (65.9% vs. 41.0%; p=0.005) and female sex (65.9% vs. 44.4%; p=0.015). In the subgroup with VDD, higher values of hemoglobin A1c (7.9% [6.0-8.9] vs. 6.2% [5.7-7.9]; p=0.006) and dyslipidemia were also observed. Conclusions: We found higher rates of VDD in patients hospitalized for HF and this was associated with deleterious laboratory metabolic parameters.

Keywords

Acknowledgement

The authors would like to thank the Endocrinology and Cardiology divisions of the Institution for making the research possible.

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