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Pleiotropic Effect of Dronedarone Beyond Antiarrhythmic Agent: Reduction of Hypertrophy

  • Jung-Joon Cha (Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Korea University College of Medicine)
  • 투고 : 2024.02.14
  • 심사 : 2024.02.26
  • 발행 : 2024.04.01

초록

키워드

참고문헌

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  3. Hohnloser SH, Crijns HJ, van Eickels M, et al.; ATHENA Investigators. Effect of dronedarone on cardiovascular events in atrial fibrillation. N Engl J Med 2009;360:668-78.
  4. Rosa GM, Bianco D, Parodi A, et al. Pharmacokinetic and pharmacodynamic profile of dronedarone, a new antiarrhythmic agent for the treatment of atrial fibrillation. Expert Opin Drug Metab Toxicol 2014;10:1751-64.
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  7. Quintana-Villamandos B, Gomez de Diego JJ, Delgado-Martos MJ, et al. Dronedarone produces early regression of myocardial remodelling in structural heart disease. PLoS One 2017;12:e0188442.
  8. Chen C, Hu S, Hu HJ, et al. Dronedarone attenuates Ang II-induced myocardial hypertrophy through regulating SIRT1/FOXO3/PKIA axis. Korean Circ J 2024;54:172-86.
  9. Sotomayor-Flores C, Rivera-Mejias P, Vasquez-Trincado C, et al. Angiotensin-(1-9) prevents cardiomyocyte hypertrophy by controlling mitochondrial dynamics via miR-129-3p/PKIA pathway. Cell Death Differ 2020;27:2586-604.
  10. Pazo-Sayos L, Gonzalez MC, Quintana-Villamandos B. Inhibition of the NFATc4/ERK/AKT pathway and improvement of thiol-specific oxidative stress by dronedarone possibly secondary to the reduction of blood pressure in an animal model of ventricular hypertrophy. Front Physiol 2020;11:967.