DOI QR코드

DOI QR Code

What is the disease burden from childhood and adolescent obesity?: a narrative review

  • Eun Byoul Lee (Department of Pediatrics, Yongin Severance Hospital, Yonsei University College of Medicine)
  • Received : 2024.04.08
  • Accepted : 2024.06.03
  • Published : 2024.07.31

Abstract

The prevalence of childhood and adolescent obesity has increased and exacerbated during the coronavirus disease 2019 pandemic, both in Korea and globally. Childhood and adolescent obesity poses significant risks for premature morbidity and mortality. The development of serious comorbidities depends not only on the duration of obesity but also on the age of onset. Obesity in children and adolescents affects almost all organ systems, including the endocrine, cardiovascular, gastrointestinal, reproductive, nervous, and immune systems. Obesity in children and adolescents affects growth, cognitive function, and psychosocial interactions during development, in addition to aggravating known adult comorbidities such as type 2 diabetes mellitus, hypertension, dyslipidemia, nonalcoholic fatty liver disease, obstructive sleep apnea, and cancer. Childhood and adolescent obesity are highly associated with increased cardiometabolic risk factors and prevalence of metabolic syndrome. The risk of cardiovascular and metabolic diseases in later life can be considerably decreased by even a small weight loss before the onset of puberty. Childhood and adolescent obesity is a disease that requires treatment and is associated with many comorbidities and disease burdens. Therefore, early detection and therapeutic intervention are crucial.

Keywords

References

  1. Lustig RH, Collier D, Kassotis C, Roepke TA, Kim MJ, Blanc E, et al. Obesity I: overview and molecular and biochemical mechanisms. Biochem Pharmacol 2022;199:115012.
  2. Kim JH, Moon JS. Secular trends in pediatric overweight and obesity in Korea. J Obes Metab Syndr 2020;29:12-7.
  3. Park H, Choi JE, Jun S, Lee H, Kim HS, Lee HA, et al. Metabolic complications of obesity in children and adolescents. Clin Exp Pediatr 2024;67:347-55.
  4. Takaya J, Higashino H, Takaya R, Sakaguchi H, Tanoue J, Higashide T, et al. Effect of the COVID-19 pandemic lockdown on the physique of school-age children in Japan. Ann Pediatr Endocrinol Metab 2023;28:124-30.
  5. Jeong SM, Jung JH, Yang YS, Kim W, Cho IY, Lee YB, et al. 2023 Obesity Fact Sheet: prevalence of obesity and abdominal obesity in adults, adolescents, and children in Korea from 2012 to 2021. J Obes Metab Syndr 2024;33:27-35.
  6. Hong YH. Suggestions for the management of pediatric obesity in Korea. J Korean Med Assoc 2024;67:306-11.
  7. Freedman DS, Khan LK, Serdula MK, Dietz WH, Srinivasan SR, Berenson GS. The relation of childhood BMI to adult adiposity: the Bogalusa Heart Study. Pediatrics 2005;115:22-7.
  8. Simmonds M, Llewellyn A, Owen CG, Woolacott N. Predicting adult obesity from childhood obesity: a systematic review and meta-analysis. Obes Rev 2016;17:95-107.
  9. Marcus C, Danielsson P, Hagman E. Pediatric obesityLong-term consequences and effect of weight loss. J Intern Med 2022;292:870-91.
  10. Malhotra S, Sivasubramanian R, Singhal V. Adult obesity and its complications: a pediatric disease? Curr Opin Endocrinol Diabetes Obes 2021;28:46-54.
  11. Weihrauch-Bluher S, Schwarz P, Klusmann JH. Childhood obesity: increased risk for cardiometabolic disease and cancer in adulthood. Metabolism 2019;92:147-52.
  12. Horesh A, Tsur AM, Bardugo A, Twig G. Adolescent and childhood obesity and excess morbidity and mortality in young adulthood: a systematic review. Curr Obes Rep 2021;10:301-10.
  13. Galic S, Oakhill JS, Steinberg GR. Adipose tissue as an endocrine organ. Mol Cell Endocrinol 2010;316:129-39.
  14. Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB. Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Front Endocrinol (Lausanne) 2016;7:30.
  15. Zatterale F, Longo M, Naderi J, Raciti GA, Desiderio A, Miele C, et al. Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes. Front Physiol 2019;10:1607.
  16. Skinner AC, Perrin EM, Moss LA, Skelton JA. Cardiometabolic risks and severity of obesity in children and young adults. N Engl J Med 2015;373:1307-17.
  17. Kim JI, Huh JY, Sohn JH, Choe SS, Lee YS, Lim CY, et al. Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation. Mol Cell Biol 2015;35:1686-99.
  18. Yoo SE, Lee JH, Lee JW, Park HS, Lee HA, Kim HS. Increasing prevalence of fasting hyperglycemia in adolescents aged 10-18 years and its relationship with metabolic indicators: the Korea National Health and Nutrition Examination Study (KNHANES), 2007-2018. Ann Pediatr Endocrinol Metab 2022;27:60-8.
  19. Vigone MC, Capalbo D, Weber G, Salerno M. Mild hypothyroidism in childhood: who, when, and how should be treated? J Endocr Soc 2018;2:1024-39.
  20. Lundback V, Ekbom K, Hagman E, Dahlman I, Marcus C. Thyroid-stimulating hormone, degree of obesity, and metabolic risk markers in a cohort of swedish children with obesity. Horm Res Paediatr 2017;88:140-6.
  21. Rotondi M, Leporati P, La Manna A, Pirali B, Mondello T, Fonte R, et al. Raised serum TSH levels in patients with morbid obesity: is it enough to diagnose subclinical hypothyroidism? Eur J Endocrinol 2009;160:403-8.
  22. Baker JL, Olsen LW, Sorensen TI. Childhood body-mass index and the risk of coronary heart disease in adulthood. N Engl J Med 2007;357:2329-37.
  23. Wuhl E. Hypertension in childhood obesity. Acta Paediatr 2019;108:37-43.
  24. McPhee PG, Singh S, Morrison KM. Childhood obesity and cardiovascular disease risk: working toward solutions. Can J Cardiol 2020;36:1352-61.
  25. Nadeau KJ, Maahs DM, Daniels SR, Eckel RH. Childhood obesity and cardiovascular disease: links and prevention strategies. Nat Rev Cardiol 2011;8:513-25.
  26. Juonala M, Magnussen CG, Berenson GS, Venn A, Burns TL, Sabin MA, et al. Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med 2011;365:1876-85.
  27. Kim M, Kim J. Cardiometabolic risk factors and metabolic syndrome based on severity of obesity in Korean children and adolescents: data from the Korea National Health and Nutrition Examination Survey 2007-2018. Ann Pediatr Endocrinol Metab 2022;27:289-99.
  28. Kim HY, Kim JH. Temporal trends in the prevalence of metabolically healthy overweight and obesity in Korean youth: data from the Korea National Health and Nutrition Examination Survey 2011-2019. Ann Pediatr Endocrinol Metab 2022;27:134-41.
  29. Shulhai AM, Pavlyshyn H, Oleksandra S, Furdela V. The association between vitamin D deficiency and metabolic syndrome in Ukrainian adolescents with overweight and obesity. Ann Pediatr Endocrinol Metab 2022;27:113-20.
  30. Anderson EL, Howe LD, Jones HE, Higgins JP, Lawlor DA, Fraser A. The prevalence of non-alcoholic fatty liver disease in children and adolescents: a systematic review and meta-analysis. PLoS One 2015;10:e0140908.
  31. Shaunak M, Byrne CD, Davis N, Afolabi P, Faust SN, Davies JH. Non-alcoholic fatty liver disease and childhood obesity. Arch Dis Child 2021;106:3-8.
  32. Song K, Yang J, Lee HS, Kim SJ, Lee M, Suh J, et al. Changes in the prevalences of obesity, abdominal obesity, and non-alcoholic fatty liver disease among Korean children during the COVID-19 outbreak. Yonsei Med J 2023;64:269-77.
  33. Eslam M, Alkhouri N, Vajro P, Baumann U, Weiss R, Socha P, et al. Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement. Lancet Gastroenterol Hepatol 2021;6:864-73.
  34. Koebnick C, Smith N, Black MH, Porter AH, Richie BA, Hudson S, et al. Pediatric obesity and gallstone disease. J Pediatr Gastroenterol Nutr 2012;55:328-33.
  35. Shalitin S, Gat-Yablonski G. Associations of obesity with linear growth and puberty. Horm Res Paediatr 2022;95:120-36.
  36. Holmgren A, Niklasson A, Nierop AF, Gelander L, Aronson AS, Sjoberg A, et al. Pubertal height gain is inversely related to peak BMI in childhood. Pediatr Res 2017;81:448-54.
  37. Kim SJ, Kim JH, Hong YH, Chung IH, Lee EB, Kang E, et al. 2022 Clinical practice guidelines for central precocious puberty of Korean children and adolescents. Ann Pediatr Endocrinol Metab 2023;28:168-77.
  38. Burt Solorzano CM, McCartney CR. Obesity and the pubertal transition in girls and boys. Reproduction 2010;140:399-410.
  39. Lee JM, Kaciroti N, Appugliese D, Corwyn RF, Bradley RH, Lumeng JC. Body mass index and timing of pubertal initiation in boys. Arch Pediatr Adolesc Med 2010;164:139-44.
  40. Wang Y. Is obesity associated with early sexual maturation? A comparison of the association in American boys versus girls. Pediatrics 2002;110:903-10.
  41. Song Y, Kong Y, Xie X, Wang Y, Wang N. Association between precocious puberty and obesity risk in children: a systematic review and meta-analysis. Front Pediatr 2023;11:1226933.
  42. Brix N, Ernst A, Lauridsen LL, Parner ET, Arah OA, Olsen J, et al. Childhood overweight and obesity and timing of puberty in boys and girls: cohort and sibling-matched analyses. Int J Epidemiol 2020;49:834-44.
  43. Hunter E, Avenell A, Maheshwari A, Stadler G, Best D. The effectiveness of weight-loss lifestyle interventions for improving fertility in women and men with overweight or obesity and infertility: a systematic review update of evidence fromrandomized controlled trials. Obes Rev 2021;22:e13325.
  44. Lindberg L, Persson M, Danielsson P, Hagman E, Marcus C. Obesity in childhood, socioeconomic status, and completion of 12 or more school years: a prospective cohort study. BMJ Open 2021;11:e040432.
  45. Alosco ML, Spitznagel MB, Strain G, Devlin M, Cohen R, Paul R, et al. Improved memory function two years after bariatric surgery. Obesity (Silver Spring) 2014;22:32-8.
  46. Smith JD, Fu E, Kobayashi MA. Prevention and management of childhood obesity and its psychological and health comorbidities. Annu Rev Clin Psychol 2020;16:351-78.
  47. Blasco BV, Garcia-Jimenez J, Bodoano I, Gutierrez-Rojas L. Obesity and depression: its prevalence and influence as a prognostic factor: a systematic review. Psychiatry Investig 2020;17:715-24.
  48. Kang NR, Kwack YS. An update on mental health problems and cognitive behavioral therapy in pediatric obesity. Pediatr Gastroenterol Hepatol Nutr 2020;23:15-25.
  49. Mannan M, Mamun A, Doi S, Clavarino A. Prospective associations between depression and obesity for adolescent males and females: a systematic review and meta-analysis of longitudinal studies. PLoS One 2016;11:e0157240.
  50. Quek YH, Tam WW, Zhang MW, Ho RC. Exploring the association between childhood and adolescent obesity and depression: a meta-analysis. Obes Rev 2017;18:742-54.
  51. Moradi M, Mozaffari H, Askari M, Azadbakht L. Association between overweight/obesity with depression, anxiety, low self-esteem, and body dissatisfaction in children and adolescents: a systematic review and meta-analysis of observational studies. Crit Rev Food Sci Nutr 2022;62:555-70.
  52. O'Hara VM, Curran JL, Browne NT. The co-occurrence of pediatric obesity and ADHD: an understanding of shared pathophysiology and implications for collaborative management. Curr Obes Rep 2020;9:451-61.
  53. Erhart M, Herpertz-Dahlmann B, Wille N, Sawitzky-Rose B, Holling H, Ravens-Sieberer U. Examining the relationship between attention-deficit/hyperactivity disorder and overweight in children and adolescents. Eur Child Adolesc Psychiatry 2012;21:39-49.
  54. Carpaij OA, van den Berge M. The asthma-obesity relationship: underlying mechanisms and treatment implications. Curr Opin Pulm Med 2018;24:42-9.
  55. Ng NB, Lim CY, Tan SC, Foo YW, Tok CL, Lim YY, et al. Screening for obstructive sleep apnea (OSA) in children and adolescents with obesity: a scoping review of national and international pediatric obesity and pediatric OSA management guidelines. Obes Rev 2024;25:e13712.
  56. Lee JH, Cho J. Sleep and obesity. Sleep Med Clin 2022;17:111-6.
  57. Seo SH, Shim YS. Association of sleep duration with obesity and cardiometabolic risk factors in children and adolescents: a population-based study. Sci Rep 2019;9:9463.
  58. Kwon A, Choi Y, Kim S, Song K, Suh J, Chae HW, et al. Characteristic sleep patterns and associated obesity in adolescents. Life (Basel) 2022;12:1316.
  59. Choi Y, Kim S, Lee M, Lee HI, Song K, Suh J, et al. Effect of catch-up sleep on obesity in Korean adolescents: a nationwide cross-sectional study. Front Pediatr 2023;11:1213558.
  60. Fintini D, Cianfarani S, Cofini M, Andreoletti A, Ubertini GM, Cappa M, et al. The bones of children with obesity. Front Endocrinol (Lausanne) 2020;11:200.
  61. Kim SJ, Ahn J, Kim HK, Kim JH. Obese children experience more extremity fractures than nonobese children and are significantly more likely to die from traumatic injuries. Acta Paediatr 2016;105:1152-7.
  62. Pollock NK. Childhood obesity, bone development, and cardiometabolic risk factors. Mol Cell Endocrinol 2015;410:52-63.
  63. Fiamenghi VI, Mello ED. Vitamin D deficiency in children and adolescents with obesity: a meta-analysis. J Pediatr (Rio J) 2021;97:273-9.
  64. Naganuma J, Koyama S, Arisaka O, Yoshihara S. Low serum 25-hydroxyvitamin D level is associated with obesity and atherogenesis in adolescent boys. Ann Pediatr Endocrinol Metab 2022;27:30-6.
  65. Karampela I, Sakelliou A, Vallianou N, Christodoulatos GS, Magkos F, Dalamaga M. Vitamin D and obesity: current evidence and controversies. Curr Obes Rep 2021;10:162-80.
  66. Francisco V, Pino J, Campos-Cabaleiro V, Ruiz-Fernandez C, Mera A, Gonzalez-Gay MA, et al. Obesity, fat mass and immune system: role for leptin. Front Physiol 2018;9:640.
  67. de Oliveira Dos Santos AR, de Oliveira Zanuso B, Miola VF, Barbalho SM, Santos Bueno PC, Flato UA, et al. Adipokines, myokines, and hepatokines: crosstalk and metabolic repercussions. Int J Mol Sci 2021;22:2639.
  68. Blaszczak AM, Jalilvand A, Hsueh WA. Adipocytes, innate immunity and obesity: a mini-review. Front Immunol 2021;12:650768.
  69. Versini M, Jeandel PY, Rosenthal E, Shoenfeld Y. Obesity in autoimmune diseases: not a passive bystander. Autoimmun Rev 2014;13:981-1000.
  70. Knerr I, Wolf J, Reinehr T, Stachow R, Grabert M, Schober E, et al. The 'accelerator hypothesis': relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9,248 German and Austrian children with type 1 diabetes mellitus. Diabetologia 2005;48:2501-4.
  71. Choi HM, Doss HM, Kim KS. Multifaceted physiological roles of adiponectin in inflammation and diseases. Int J Mol Sci 2020;21:1219.
  72. Weihe P, Spielmann J, Kielstein H, Henning-Klusmann J, Weihrauch-Bluher S. Childhood obesity and cancer risk in adulthood. Curr Obes Rep 2020;9:204-12.
  73. Kim KN, Hwang Y, Kim KH, Lee KE, Park YJ, Kim SJ, et al. Adolescent overweight and obesity and the risk of papillary thyroid cancer in adulthood: a large-scale case-control study. Sci Rep 2020;10:5000.