Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Homocysteine levels are associated with diabetes mellitus in Chinese with H-type hypertension

  • Dejian Fu (Department of Cardiovascular, The People's Hospital of Zigui County) ;
  • Wanbao Gong (Department of Cardiovascular, Changyang Tujia Autonomous County People's Hospital) ;
  • Xiaomin Bao (Department of Cardiovascular, People's Hospital of Huantai County) ;
  • Bo Yang (Department of Cardiovascular, The People's Hospital of Wufeng Tujia Autonomous County) ;
  • Feng Wang (Clinical laboratory, The People's Hospital of Wufeng Tujia Autonomous County) ;
  • Yubing Qiao (Department of Cardiovascular, Zigui County Hospital of Traditional Chinese Medicine) ;
  • Yuanjiang Wu (Clinical laboratory, Zigui County Hospital of Traditional Chinese Medicine) ;
  • Guangzhen Chen (Department of Cardiovascular, The People's Hospital of Wufeng Tujia Autonomous County) ;
  • Weixun Sun (Clinical laboratory, Changyang Tujia Autonomous County People's Hospital) ;
  • Qiongzhi Xiao (Department of Cardiovascular, The People's Hospital of Wufeng Tujia Autonomous County) ;
  • Wenbo Zou (Department of Cardiovascular, Yidu Hospital of Traditional Chinese Medicine) ;
  • Ning Fang (Department of Cardiovascular, Changyang Tujia Autonomous County People's Hospital)
  • Received : 2022.10.13
  • Accepted : 2024.04.15
  • Published : 2024.08.01
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Abstract

BACKGROUND/OBJECTIVES: The study examined the association between homocysteine and diabetes mellitus in patients with H-type hypertension and assessed the possible effect modifiers. SUBJECTS/METHODS: This cross-sectional study included 1,255 eligible participants in the 'H-type Hypertension Management and Stroke Prevention Strategic International Science and Technology Innovation Cooperation Project' among rural Chinese people with H-type hypertension. A multivariate logistic regression model was used to evaluate the relationship between homocysteine and diabetes mellitus. RESULTS: The mean level of total homocysteine (tHcy) in the diabetes mellitus population was 19.37 μmol/L, which was significantly higher than the non-diabetic patients (18.18 μmol/L). When tHcy was analyzed as a continuous variable, the odds ratio (OR) of diabetes was 1.17 (95% confidence interval [CI], 1.01-1.35; per interquartile range). When tHcy was stratified according to the quintile, the ORs for diabetes were 2.86 (95% CI, 1.22-6.69) in the highest quintile (tHcy ≥ 20.60 μmol/L) compared to the reference group (tHcy < 12.04 μmol/L). When tHcy was grouped by 15 μmol/L and 20 μmol/L, patients with tHcy ≥ 20 μmol/L had a significantly (P = 0.037) higher risk of diabetes (OR, 2.03; 95% CI, 1.04-3.96) than in those with tHcy < 15 μmol/L. Subgroup analysis showed that the tHcy-diabetes association was unaffected by other variables. CONCLUSION: In this study of rural Chinese people with H-type hypertension, the tHcy levels showed a positive association with diabetes mellitus. This independent association is unaffected by other potential risk factors.

Keywords

Acknowledgement

We thank all the participants for their important contributions. In particular, we would like to acknowledge the lead units for this study, Peking University First Hospital and The Second Affiliated Hospital of Nanchang University.

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