Journal of Veterinary Science

The Korean Society of Veterinary Science (대한수의학회)
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Pharmacokinetics of oxytetracycline in hybrid catfish (Clarias macrocephalus x C. gariepinus) after intravascular and oral administrations

  • Amnart Poapolathep (Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University) ;
  • Kednapat Sriphairoj (Department of Agriculture and Resources, Faculty of Natural Resources and Agro-Industry, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus) ;
  • Sittichai Hatachote (Department of Agriculture and Resources, Faculty of Natural Resources and Agro-Industry, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus) ;
  • Kannika Wongpanit (Department of Agriculture and Resources, Faculty of Natural Resources and Agro-Industry, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus) ;
  • Duangkamol Saensawath (Department of Agriculture and Resources, Faculty of Natural Resources and Agro-Industry, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus) ;
  • Narumol Klangkaew (Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University) ;
  • Napasorn Phaochoosak (Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University) ;
  • Mario Giorgi (Department of Veterinary Science, University of Pisa) ;
  • Saranya Poapolathep (Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University)
  • Received : 2024.04.23
  • Accepted : 2024.07.10
  • Published : 2024.07.31
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Abstract

Importance: Over the past decade, catfish farming has increased in Southeast Asia. However, there has been no existing for pharmacokinetic data in the hybrid catfish (Clarias macrocephalus x C. gariepinus). Objective: This study was designed to evaluate the pharmacokinetic characteristics of oxytetracycline (OTC) in the hybrid catfish, following single intravascular (IV) or oral (PO) administration at a single dosage of 50 mg/kg body weight (BW). Methods: In total, 140 catfish (each about 100-120 g BW) were divided into two groups (n = 70). Blood samples (0.6-0.8 mL) were collected from ventral caudal vein at pre-assigned times up to 144 h (sparse samples design). OTC plasma concentrations were analyzed using high-performance liquid chromatography-photodiode array detector. Results: The pharmacokinetic parameter of OTC was evaluated using a non-compartment model. OTC plasma concentrations were detectable for up to 144 and 120 h after IV and PO, respectively. The elimination half-life value of OTC was long with slow clearance after IV administration in hybrid catfish. The average maximum concentration value of OTC was 2.72 ㎍/mL with a time at the maximum concentration of 8 h. The absolute PO bioavailability was low (2.47%). Conclusions and Relevance: These results showed that PO administration of OTC at a dosage of 50 mg/kg BW was unlikely to be effective for clinical use in catfish. The pharmacodynamic properties and clinical efficacy of OTC after multiple medicated feed are warranted.

Keywords

Acknowledgement

This work was funded by the Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.

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