Clinical Nutrition Research

  • 제13권2호
  • /
  • Pages.89-95
  • /
  • 2024
  • /
  • 2287-3732(pISSN)
  • /
  • 2287-3740(eISSN)
한국임상영양학회 (The Korean Society of Clinical Nutrition)
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Effect of Thickened Beverage and Swallowing Aid Jelly Used for Dysphagic Patients on the Disintegration of Orally Administered Tablets

  • Won Hyeong Cho (Department of Food Science and Biotechnology, Dongguk University-Seoul) ;
  • Whachun Yoo (Rheosfood Inc.) ;
  • Byoungseung Yoo (Department of Food Science and Biotechnology, Dongguk University-Seoul)
  • 투고 : 2024.02.16
  • 심사 : 2024.04.19
  • 발행 : 2024.04.30
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초록

Thickened beverages or swallowing aid jelly (SAJ), commonly used as tablet-swallowing aids for dysphagic patients, may influence the disintegration of orally administered tablets. With this in mind, we evaluated the disintegration times of therapeutic tablets immersed in thickened beverages or SAJ compared to immersion in ones without them. Thickened beverages and SAJs were prepared with various beverages (water, orange juice, and milk) using food thickeners and SAJ powders marketed in Korea. The tablet disintegration times were the same in thickened beverages and SAJs, and there was no statistically significant difference associated with the thickness levels of the thickened beverages. The disintegration times of Tylenol immersed in orange juice or milk were slightly higher compared to those immersed in water. Moreover, there was no difference in disintegration time when using the thickened beverages and SAJs. The disintegration times of Aspirin were similar in all of the thickened beverages or SAJs, and there were no differences between non-immersed and immersed tablets. These results demonstrate that the disintegration of Tylenol and Aspirin is not greatly affected by immersion in any of the thickened beverages and SAJs.

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과제정보

We would like to thank Rheosfood Inc. for providing free food thickener and swallowing aid jelly powder (Visco-up®) samples.

참고문헌

  1. Tomita T, Yamaguchi A, Nishimura N, Goto H, Sumiya K, Arakawa R, Yoshida T, Tachiki H, Kohda Y, Kudo K. Effect of food thickener and jelly wafer on the pharmacokinetics of levofloxacin orally disintegrating tablets. Heliyon (Lond) 2019;5:e02764. 
  2. Lim W, Jeong Y, Yoo B. Rheological information of pudding-thick liquids prepared using commercial food thickeners marketed in Korea for dysphagic patients according to the manufacturers' guidelines. Clin Nutr Res 2022;11:1-8. 
  3. Patel S, Scott N, Patel K, Mohylyuk V, McAuley WJ, Liu F. Easy to swallow "instant" jelly formulations for sustained release gliclazide delivery. J Pharm Sci 2020;109:2474-84. 
  4. Matsuo T, Sato C, Tomita T, Sadzuka Y. Effects of thickened drinks on the disintegration of various oral tablets. Heliyon (Lond) 2020;6:e05800. 
  5. Matsuo T, Sato A, Kudo K, Sadzuka Y, Tomita T. Appropriate usage of food thickening agents to prevent non-disintegration of magnesium oxide tablets. Sci Rep 2020;10:16089. 
  6. Ebata R, Fujita Y, Nakamura A, Harada T. Effect of film coating on xanthan gum solution-induced delays in the disintegration and dissolution of tablets. Iryo Yakugaku 2019;45:182-94. 
  7. Ministry of Food and Drug Safety. The Korean pharmacopoeia. 12th ed. Cheongju: Ministry of Food and Drug Safety; 2019. 
  8. Yoon SN, Yoo B. Rheological behaviors of thickened infant formula prepared with xanthan gum-based food thickeners for dysphagic infants. Dysphagia 2017;32:454-62. 
  9. Seo CW, Yoo B. Steady and dynamic shear rheological properties of gum-based food thickeners used for diet modification of patients with dysphagia: effect of concentration. Dysphagia 2013;28:205-11. 
  10. Stern AI, Hogan DL, Kahn LH, Isenberg JI. Protective effect of acetaminophen against aspirin- and ethanol-induced damage to the human gastric mucosa. Gastroenterology 1984;86:728-33. 
  11. Desai PM, Liew CV, Heng PWS. Review of disintegrants and the disintegration phenomena. J Pharm Sci 2016;105:2545-55. 
  12. Matsuo T, Tabata Y, Sasaki H, Yoshida Y, Gotoh Y, Suzuki T, Obara M, Sadzuka Y, Tomita T. Effects of yogurt as a deglutition aid on disintegration and dissolution of oral tablets. J Texture Stud 2022;53:396-404.