International Journal of Stem Cells

Korean Society for Stem Cell Research (한국줄기세포학회)
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Exploring the Molecular and Developmental Dynamics of Endothelial Cell Differentiation

  • Yu Jung Shin (Department of Bioengineering, University of Washington) ;
  • Jung Hyun Lee (Institute for Stem Cell and Regenerative Medicine, University of Washington)
  • Received : 2023.06.11
  • Accepted : 2023.09.05
  • Published : 2024.02.28
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Abstract

The development and differentiation of endothelial cells (ECs) are fundamental processes with significant implications for both health and disease. ECs, which are found in all organs and blood vessels, play a crucial role in facilitating nutrient and waste exchange and maintaining proper vessel function. Understanding the intricate signaling pathways involved in EC development holds great promise for enhancing vascularization, tissue engineering, and vascular regeneration. Hematopoietic stem cells originating from hemogenic ECs, give rise to diverse immune cell populations, and the interaction between ECs and immune cells is vital for maintaining vascular integrity and regulating immune responses. Dysregulation of vascular development pathways can lead to various diseases, including cancer, where tumor-specific ECs promote tumor growth through angiogenesis. Recent advancements in single-cell genomics and in vivo genetic labeling have shed light on EC development, plasticity, and heterogeneity, uncovering tissue-specific gene expression and crucial signaling pathways. This review explores the potential of ECs in various applications, presenting novel opportunities for advancing vascular medicine and treatment strategies.

Keywords

Acknowledgement

This work was supported by the Elsa U Pardee Foundation (to JHL), MCC patient gift fund (to JHL), and American Heart Association Predoctoral fellowship (AHA 23PRE1014179, to YJS).

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