Current Optics and Photonics

Optical Society of Korea (한국광학회)
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Utilizing Optical Phantoms for Biomedical-optics Technology: Recent Advances and Challenges

  • Ik Hwan Kwon (Division of Biomedical Metrology, Korea Research Institute of Standards and Science) ;
  • Hoon-Sup Kim (Division of Biomedical Metrology, Korea Research Institute of Standards and Science) ;
  • Do Yeon Kim (Division of Biomedical Metrology, Korea Research Institute of Standards and Science) ;
  • Hyun-Ji Lee (Division of Biomedical Metrology, Korea Research Institute of Standards and Science) ;
  • Sang-Won Lee (Division of Biomedical Metrology, Korea Research Institute of Standards and Science)
  • Received : 2024.06.24
  • Accepted : 2024.07.11
  • Published : 2024.08.25
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Abstract

Optical phantoms are essential in optical imaging and measurement instruments for performance evaluation, calibration, and quality control. They enable precise measurement of image resolution, accuracy, sensitivity, and contrast, which are crucial for both research and clinical diagnostics. This paper reviews the recent advancements and challenges in phantoms for optical coherence tomography, photoacoustic imaging, digital holographic microscopy, optical diffraction tomography, and oximetry tools. We explore the fundamental principles of each technology, the key factors in phantom development, and the evaluation criteria. Additionally, we discuss the application of phantoms used for enhancing optical-image quality. This investigation includes the development of realistic biological and clinical tissue-mimicking phantoms, emphasizing their role in improving the accuracy and reliability of optical imaging and measurement instruments in biomedical and clinical research.

Keywords

Acknowledgement

In part by the Korea Medical Device Development Fund grants funded by the Korean government (Ministry of Science and ICT, Ministry of Trade, Industry and Energy, Ministry of Health & Welfare, Ministry of Food and Drug Safety) (Project No. KMDF_PR_20200901_0024 and KMDF_PR_20200901_0026); In part by the National Research Council of Science & Technology (NST) grant by the Korea government (MSIT) (GTL24021-500); Development of Measurement Standards and Technology for Biomaterials and Medical Convergence funded by the Korea Research Institute of Standards and Science (Grant no. KRISS-GP2024-0007).

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