Clinical Endoscopy

The Korean Society of Gastrointestinal Endoscopy (대한소화기내시경학회)
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Efficacy of an assistive guide tube for improved endoscopic access to gastrointestinal lesions: an in vivo study in a porcine model

  • Dong Seok Lee (Department of Gastroenterology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Jeong-Sik Byeon (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Sang Gyun Kim (Department of Gastroenterology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Ji Won Kim (Department of Gastroenterology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine) ;
  • Kook Lae Lee (Department of Gastroenterology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine) ;
  • Ji Bong Jeong (Department of Gastroenterology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine) ;
  • Yong Jin Jung (Department of Gastroenterology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine) ;
  • Hyoun Woo Kang (Department of Gastroenterology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine)
  • Received : 2022.06.04
  • Accepted : 2023.01.02
  • Published : 2024.01.30
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Abstract

Background/Aims: Guide tube-assisted endoscopy for procedures that require repeated endoscopic access is safer and more effective than conventional endoscopy. However, its effectiveness has not been confirmed in animal studies. We assessed the usefulness of guide tube-assisted endoscopic procedures in an in vivo porcine model. Methods: Five different guide tube-assisted endoscopic procedures were performed by experienced endoscopists on a pig weighing 32 kg. To evaluate the efficacy of these procedures, we compared the endoscopic approach time when a guide tube was used to that when it was not. Additional endoscopic procedures using a guide tube were performed, including multiple foreign body extractions, multiple polypectomies, and multiple submucosal dissections. To evaluate safety, we compared the insertion force into the proximal esophagus between the guide tube and conventional overtube methods. Results: Using the endoscopic approach with a guide tube required a shorter average approach time to reach the three target lesions than when using the endoscopic approach without a guide tube (p<0.001). Compared to the conventional overtube method, the guide tube method produced a lower average resistance during insertion into the upper esophagus (p<0.001). Conclusions: Guide tube-assisted endoscopic procedures are effective and safe for repeated endoscopic access in an in vivo porcine model.

Keywords

Acknowledgement

This work was supported by a clinical research grant-in-aid from Seoul National University Boramae Medical Center (03-2019-4) and the National Center of Efficacy Evaluation for the Development of Health Products Targeting Digestive Disorders.

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