대한치매학회지 (Dementia and Neurocognitive Disorders)

대한치매학회 (Korean Dementia Association)
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Ventral Anterior Cingulate Atrophy as a Predisposing Factor for Transient Global Amnesia

  • Jeewon Suh (Department of Neurology, Seoul National University Bundang Hospital) ;
  • Young Ho Park (Department of Neurology, Seoul National University Bundang Hospital) ;
  • Hang-Rai Kim (Department of Neurology, Dongguk University Ilsan Hospital) ;
  • Jae-Won Jang (Department of Neurology, Kangwon National University Hospital, Kangwon National University College of Medicine) ;
  • SangHak Yi (Department of Neurology, Wonkwang University School of Medicine and Regional Cardiocerebrovascular Center) ;
  • Min Ju Kang (Department of Neurology, Veterans Health Service Medical Center) ;
  • Yun Jung Bae (Department of Radiology, Seoul National University Bundang Hospital) ;
  • Byung Se Choi (Department of Radiology, Seoul National University Bundang Hospital) ;
  • Jae Hyoung Kim (Department of Radiology, Seoul National University Bundang Hospital) ;
  • SangYun Kim (Department of Neurology, Seoul National University Bundang Hospital)
  • 투고 : 2023.12.10
  • 심사 : 2024.02.16
  • 발행 : 2024.04.30
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초록

Background and Purpose: This study aimed to evaluate the brain magnetic resonance imaging (MRI) of patients with acute transient global amnesia (TGA) using volumetric analysis to verify whether the brains of TGA patients have pre-existing structural abnormalities. Methods: We evaluated the brain MRI data from 87 TGA patients and 20 age- and sex- matched control subjects. We included brain MRIs obtained from TGA patients within 72 hours of symptom onset to verify the pre-existence of structural change. For voxel-based morphometric analyses, statistical parametric mapping was employed to analyze the structural differences between patients with TGA and control subjects. Results: TGA patients exhibited significant volume reductions in the bilateral ventral anterior cingulate cortices (corrected p<0.05). Conclusions: TGA patients might have pre-existing structural changes in bilateral ventral anterior cingulate cortices prior to TGA attacks.

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참고문헌

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