Dementia and Neurocognitive Disorders (대한치매학회지)

Korean Dementia Association (대한치매학회)
권호 표지
DOI QR코드

DOI QR Code

Ventral Anterior Cingulate Atrophy as a Predisposing Factor for Transient Global Amnesia

  • Jeewon Suh (Department of Neurology, Seoul National University Bundang Hospital) ;
  • Young Ho Park (Department of Neurology, Seoul National University Bundang Hospital) ;
  • Hang-Rai Kim (Department of Neurology, Dongguk University Ilsan Hospital) ;
  • Jae-Won Jang (Department of Neurology, Kangwon National University Hospital, Kangwon National University College of Medicine) ;
  • SangHak Yi (Department of Neurology, Wonkwang University School of Medicine and Regional Cardiocerebrovascular Center) ;
  • Min Ju Kang (Department of Neurology, Veterans Health Service Medical Center) ;
  • Yun Jung Bae (Department of Radiology, Seoul National University Bundang Hospital) ;
  • Byung Se Choi (Department of Radiology, Seoul National University Bundang Hospital) ;
  • Jae Hyoung Kim (Department of Radiology, Seoul National University Bundang Hospital) ;
  • SangYun Kim (Department of Neurology, Seoul National University Bundang Hospital)
  • Received : 2023.12.10
  • Accepted : 2024.02.16
  • Published : 2024.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

Background and Purpose: This study aimed to evaluate the brain magnetic resonance imaging (MRI) of patients with acute transient global amnesia (TGA) using volumetric analysis to verify whether the brains of TGA patients have pre-existing structural abnormalities. Methods: We evaluated the brain MRI data from 87 TGA patients and 20 age- and sex- matched control subjects. We included brain MRIs obtained from TGA patients within 72 hours of symptom onset to verify the pre-existence of structural change. For voxel-based morphometric analyses, statistical parametric mapping was employed to analyze the structural differences between patients with TGA and control subjects. Results: TGA patients exhibited significant volume reductions in the bilateral ventral anterior cingulate cortices (corrected p<0.05). Conclusions: TGA patients might have pre-existing structural changes in bilateral ventral anterior cingulate cortices prior to TGA attacks.

Keywords

References

  1. Bartsch T, Deuschl G. Transient global amnesia: functional anatomy and clinical implications. Lancet Neurol 2010;9:205-214. https://doi.org/10.1016/S1474-4422(09)70344-8
  2. Lee HY, Kim JH, Weon YC, Lee JS, Kim SY, Youn SW, et al. Diffusion-weighted imaging in transient global amnesia exposes the CA1 region of the hippocampus. Neuroradiology 2007;49:481-487. https://doi.org/10.1007/s00234-007-0213-5
  3. Giorgio A, De Stefano N. Clinical use of brain volumetry. J Magn Reson Imaging 2013;37:1-14. https://doi.org/10.1002/jmri.23671
  4. Hodges JR, Warlow CP. Syndromes of transient amnesia: towards a classification. A study of 153 cases. J Neurol Neurosurg Psychiatry 1990;53:834-843. https://doi.org/10.1136/jnnp.53.10.834
  5. Wang MJ, Yi S, Han JY, Park SY, Jang JW, Chun IK, et al. Analysis of cerebrospinal fluid and [11C]PIB PET biomarkers for Alzheimer's disease with updated protocols. J Alzheimers Dis 2016;52:1403-1413. https://doi.org/10.3233/JAD-160143
  6. Kim J, Kwon Y, Yang Y, Jang IM, Chang Y, Park YH, et al. Clinical experience of modified diffusion-weighted imaging protocol for lesion detection in transient global amnesia: an 8-year large-scale clinical study. J Neuroimaging 2014;24:331-337. https://doi.org/10.1111/jon.12021
  7. Moon Y, Oh J, Kwon KJ, Han SH. Transient global amnesia: only in already disrupted neuronal integrity of memory network? J Neurol Sci 2016;368:187-190. https://doi.org/10.1016/j.jns.2016.05.035
  8. Park KM, Han YH, Kim TH, Mun CW, Shin KJ, Ha SY, et al. Pre-existing structural abnormalities of the limbic system in transient global amnesia. J Clin Neurosci 2015;22:843-847. https://doi.org/10.1016/j.jocn.2014.11.017
  9. Hayden BY, Platt ML. Cingulate cortex. In: Squire LR, editor. Encyclopedia of Neuroscience. Oxford: Academic Press, 2009;887-892. 
  10. Bubb EJ, Kinnavane L, Aggleton JP. Hippocampal - diencephalic - cingulate networks for memory and emotion: an anatomical guide. Brain Neurosci Adv 2017;1:2398212817723443.
  11. Vogt BA, Nimchinsky EA, Vogt LJ, Hof PR. Human cingulate cortex: surface features, flat maps, and cytoarchitecture. J Comp Neurol 1995;359:490-506. https://doi.org/10.1002/cne.903590310
  12. Vogt BA, Laureys S. Posterior cingulate, precuneal and retrosplenial cortices: cytology and components of the neural network correlates of consciousness. Prog Brain Res 2005;150:205-217. https://doi.org/10.1016/S0079-6123(05)50015-3
  13. Choo IH, Lee DY, Oh JS, Lee JS, Lee DS, Song IC, et al. Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer's disease. Neurobiol Aging 2010;31:772-779. https://doi.org/10.1016/j.neurobiolaging.2008.06.015
  14. Jones BF, Witter MP. Cingulate cortex projections to the parahippocampal region and hippocampal formation in the rat. Hippocampus 2007;17:957-976. https://doi.org/10.1002/hipo.20330
  15. Stevens FL, Hurley RA, Taber KH. Anterior cingulate cortex: unique role in cognition and emotion. J Neuropsychiatry Clin Neurosci 2011;23:121-125. https://doi.org/10.1176/jnp.23.2.jnp121
  16. Weible AP, Rowland DC, Monaghan CK, Wolfgang NT, Kentros CG. Neural correlates of long-term object memory in the mouse anterior cingulate cortex. J Neurosci 2012;32:5598-5608. https://doi.org/10.1523/JNEUROSCI.5265-11.2012
  17. Pezze MA, Marshall HJ, Fone KC, Cassaday HJ. Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay. Learn Mem 2017;24:310-317. https://doi.org/10.1101/lm.044784.116
  18. Drevets WC, Savitz J, Trimble M. The subgenual anterior cingulate cortex in mood disorders. CNS Spectr 2008;13:663-681. https://doi.org/10.1017/S1092852900013754
  19. Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 2000;4:215-222. https://doi.org/10.1016/S1364-6613(00)01483-2