대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지
DOI QR코드

DOI QR Code

코로나 관련 소화불량을 호소하는 환자의 임상적 특징 및 치료 분석 : 후향적 차트 분석

Analysis of Clinical Features and Treatment of Patients Presenting Dyspepsia Related to COVID-19: Retrospective Chart Review

  • 정나현 (경희대학교한방병원 위장소화내과) ;
  • 윤채림 (경희대학교한방병원 위장소화내과) ;
  • 최수현 (경희대학교한방병원 위장소화내과) ;
  • 정다희 (경희대학교 대학원 임상한의학과) ;
  • 심유현 (경희대학교한방병원 위장소화내과) ;
  • 정해인 (경희대학교한방병원 위장소화내과) ;
  • 하나연 (경희대학교한방병원 위장소화내과) ;
  • 김진성 (경희대학교한방병원 위장소화내과)
  • Nahyun Jeong (Division of Digestive Diseases, Dept. of Korean Internal Medicine, Kyung Hee University Korean Medicine Hospital) ;
  • Chae-Rim Yoon (Division of Digestive Diseases, Dept. of Korean Internal Medicine, Kyung Hee University Korean Medicine Hospital) ;
  • Su-Hyun Choi (Division of Digestive Diseases, Dept. of Korean Internal Medicine, Kyung Hee University Korean Medicine Hospital) ;
  • Dahee Jeong (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Yoohyun Sim (Division of Digestive Diseases, Dept. of Korean Internal Medicine, Kyung Hee University Korean Medicine Hospital) ;
  • Hae-in Jeong (Division of Digestive Diseases, Dept. of Korean Internal Medicine, Kyung Hee University Korean Medicine Hospital) ;
  • Na-Yeon Ha (Division of Digestive Diseases, Dept. of Korean Internal Medicine, Kyung Hee University Korean Medicine Hospital) ;
  • Jinsung Kim (Division of Digestive Diseases, Dept. of Korean Internal Medicine, Kyung Hee University Korean Medicine Hospital)
  • 투고 : 2024.05.28
  • 심사 : 2024.07.01
  • 발행 : 2024.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: The main purpose of this study is to investigate the clinical characteristics of patients complaining of indigestion after COVID-19 infection (CI) or COVID-19 vaccination (CV) and to confirm the effectiveness and safety of Korean medical treatment. Methods: We retrospectively collected and investigated the medical records of 39 patients admitted to the Kyung Hee University Korean Medicine Hospital with a chief complaint of dyspepsia from January 1, 2020 to February 29, 2024 who reported the onset or significant exacerbation of dyspepsia after CV or CI. Patients were divided into vaccination and infection groups, and their demographic characteristics, Ryodoraku results, presenting symptoms, traditional Korean medicine treatments, and treatment outcomes were analyzed. Results: When comparing the groups with dyspepsia after CV and after CI, it was observed that the CI group had significantly lower average body weight, and the measurements of LH6, LF1, and LF6 in the Ryodoraku test were significantly lower. Additionally, compared to the CV group, the CI group showed significantly more abdominal distension, nausea, and abdominal pain. Significant relief of upper gastrointestinal symptoms was observed in both the CV and CI groups after treatment. No adverse reactions were observed during the course of treatment. Conclusion: The CI group tended to complain more severely of various dyspeptic symptoms and had a tendency to lower body weight than the CV group, as was also reflected in the results of the Ryodoraku test. Korean medical treatment can be effective and safe in treating these patients.

키워드

참고문헌

  1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med 2020;382(8):727-33. https://doi.org/10.1056/NEJMoa2001017
  2. The end of an emergency. Nat Hum Behav 2023;7(5):657-58. https://doi.org/10.1038/s41562-023-01627-4
  3. Naming the coronavirus disease (COVID-19) and the virus that causes it. [cited 2024 May 27]; Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it.
  4. Green MS. Did the hesitancy in declaring COVID-19 a pandemic reflect a need to redefine the term? Lancet 2020;395(10229):1034-5. https://doi.org/10.1016/S0140-6736(20)30630-9
  5. Lim S, Sohn M. How to cope with emerging viral diseases: lessons from South Korea's strategy for COVID-19, and collateral damage to cardiometabolic health. Lancet Reg Health West Pac 2023;30:100581.
  6. Scholkmann F, May CA. COVID-19, post-acute COVID-19 syndrome (PACS, "long COVID") and post-COVID-19 vaccination syndrome (PCVS, "post-COVIDvac-syndrome"): Similarities and differences. Pathol Res Pract 2023;246:154497.
  7. Jeong HS, Chun BC. Signal detection of COVID-19 vaccines adverse events using spontaneous reports from South Korea. Pharmacoepidemiol Drug Saf 2023;32(9):961-8. https://doi.org/10.1002/pds.5629
  8. Chen C, Haupert SR, Zimmermann L, Shi X, Fritsche LG, Mukherjee B. Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review. J Infect Dis 2022;226(9):1593-607. https://doi.org/10.1093/infdis/jiac136
  9. Kim Y, Kim SE, Kim T, Yun KW, Lee SH, Lee E, et al. Preliminary Guidelines for the Clinical Evaluation and Management of Long COVID. Infect Chemother 2022;54(3):566-97. https://doi.org/10.3947/ic.2022.0141
  10. Kim Y, Kim SW, Chang HH, Kwon KT, Bae S, Hwang S. Significance and Associated Factors of Long-Term Sequelae in Patients after Acute COVID-19 Infection in Korea. Infect Chemother 2021;53(3):463-76. https://doi.org/10.3947/ic.2021.0022
  11. Kim Y, Bitna H, Kim SW, Chang HH, Kwon KT, Bae S, et al. Post-acute COVID-19 syndrome in patients after 12 months from COVID-19 infection in Korea. BMC Infect Dis 2022;22(1):93.
  12. Rome Foundation Research Institute and the North American Alliance for the Study of Digestive Manifestations of COVID-19. Prolonged Gastrointestinal Manifestations After Recovery From COVID-19. Clin Gastroenterol Hepatol 2024;22(5):1098-107.e3.
  13. Davis HE, McCorkell L, Vogel JM, Topol EJ. Long COVID: major findings, mechanisms and recommendations. Nat Rev Microbiol 2023;21(3):133-46. https://doi.org/10.1038/s41579-022-00846-2
  14. Lee DS, Kim JW, Lee KL, Jung YJ, Kang HW. Significance of digestive symptoms after COVID-19 vaccination: A retrospective single-center study. Am J Emerg Med 2022;58:154-8. https://doi.org/10.1016/j.ajem.2022.05.044
  15. Qian Q, Fan L, Liu W, Li J, Yue J, Wang M, et al. Direct Evidence of Active SARS-CoV-2 Replication in the Intestine. Clin Infect Dis 2021;73(3):361-6. https://doi.org/10.1093/cid/ciaa925
  16. Enaud R, Prevel R, Ciarlo E, Beaufils F, Wieers G, Guery B, et al. The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks. Front Cell Infect Microbiol 2020;10:9.
  17. Cosentino M, Marino F. Understanding the Pharmacology of COVID-19 mRNA Vaccines: Playing Dice with the Spike? Int J Mol Sci 2022;23(18):10881.
  18. Yang Z, Liu Y, Wang L, Lin S, Dai X, Yan H, et al. Traditional Chinese medicine against COVID-19: Role of the gut microbiota. Biomed Pharmacother 2022;149:112787.
  19. Yu X, Zhang S, Yan F, Su D. Comparison of clinical efficacy of Qingfei Paidu decoction combined with western medicine in 43 cases and single western medicine in 46 cases in the treatment of COVID-19. Journal of Shandong University (Health Sciences) 2020;8(12):47-53.
  20. Wang R, Peng Y, Meng H, Li X. Protective effect of polysaccharides fractions from Sijunzi decoction in reserpine-induced spleen deficiency rats. RSC advances 2016;6(65):60657-65. https://doi.org/10.1039/C6RA06361F
  21. Dhar J, Samanta J, Kochhar R. Corona Virus Disease-19 pandemic: The gastroenterologists' perspective. Indian J Gastroenterol 2020;39(3):220-31. https://doi.org/10.1007/s12664-020-01075-2
  22. Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020;579(7798):270-3. https://doi.org/10.1038/s41586-020-2012-7
  23. Futagami S, Itoh T, Sakamoto C. Systematic review with meta-analysis: post-infectious functional dyspepsia. Aliment Pharmacol Ther 2015;41(2):177-88. https://doi.org/10.1111/apt.13006
  24. Tack J, Demedts I, Dehondt G, Caenepeel P, Fischler B, Zandecki M, et al. Clinical and pathophysiological characteristics of acute-onset functional dyspepsia. Gastroenterology 2002;122(7):1738-47. https://doi.org/10.1053/gast.2002.33663
  25. Dizdar V, Gilja OH, Hausken T. Increased visceral sensitivity in Giardia-induced postinfectious irritable bowel syndrome and functional dyspepsia. Effect of the 5HT3-antagonist ondansetron. Neurogastroenterol Motil 2007;19(12):977-82. https://doi.org/10.1111/j.1365-2982.2007.00988.x
  26. Porter CK, Gormley R, Tribble DR, Cash BD, Riddle MS. The Incidence and gastrointestinal infectious risk of functional gastrointestinal disorders in a healthy US adult population. Am J Gastroenterol 2011;106(1):130-8. https://doi.org/10.1038/ajg.2010.371
  27. Committee of biofunctional medicine of whole Korean medicine university, Biofunctional medicine. Seoul: Koonja publisher; 2014, p. 132-44.
  28. Yoshio N. A Guide for Application of Ryodoraku Autonomous Nerve Regulatory Therapy. Ryodoraku Medicine and Stimulus Therapy 2018;1:1-20.
  29. Kim DW, Park JS, Kil BH, Jo HM, Jeong DH, Won JY, et al. A Case Report of Korean Medicine Treatment for a Patient with Early Dumping Syndrome with Diarrhea and Abdominal Pain after Gastrectomy. J Int Korean Med 2020;41(5):868-76. https://doi.org/10.22246/jikm.2020.41.5.868
  30. Park SE, Hong SH, Kwon OS, Seo CW, Min SS, Hong SH. Clinical Effect of Pyungjingunbitanggagam-bang on CVA Patients with Hyperlipidemia. Korean J Orient Int Med 2006;27(3):561-72.
  31. Cho JH. Review on Effects of Hyangsapyeongwi-san in Gastrointestinal Diseases. Korean J Oriental Physiology & Pathology 2010;24(1):22-5.