Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Synbiotic of Pediococcus acidilactici and Inulin Ameliorates Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Mice

  • Mingzhu Wang (Department of Animal Science, Yanbian University) ;
  • Longzhou Zhang (Department of Animal Science, Yanbian University) ;
  • Huiyan Piao (Department of Chemistry, National Demonstration Centre for Experimental Chemistry Education, Yanbian University) ;
  • Yuanming Jin (Department of Animal Science, Yanbian University) ;
  • Chengdu Cui (Department of Animal Medicine, Yanbian University) ;
  • Xin Jin (Laboratory Animal Center?Yanbian University) ;
  • Lianhua Cui (Department of Animal Science, Yanbian University) ;
  • Chunri Yan (Department of Preventive Medicine, Medical College, Yanbian University)
  • Received : 2023.09.19
  • Accepted : 2023.12.13
  • Published : 2024.03.28
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Abstract

Colitis is a major gastrointestinal disease that threatens human health. In this study, a synbiotic composed of inulin and Pediococcus acidilactici (P. acidilactici) was investigated for its ability to alleviate dextran sulfate sodium (DSS)-induced colitis. The results revealed that the synbiotic, composed of inulin and P. acidilactici, attenuated the body weight loss and disease activity index (DAI) score in mice with DSS-mediated colitis. Determination of biochemical indicators found that the synbiotic increased anti-oxidation and alleviated inflammation in mice. Additionally, histopathological examination revealed that colonic goblet cell loss and severe mucosal damage in the model group were significantly reversed by the combination of inulin and P. acidilactici. Moreover, synbiotic treatment significantly reduced the levels of IL-1β, TNF-α, and IL-6 in the serum of mice. Thus, a synbiotic composed of inulin and P. acidilactici has preventive and therapeutic effects on DSS-induced colitis in mice.

Keywords

Acknowledgement

This work was carried out with the support of the Major Science and Technology Special Project for the Industrialization and Development of Beef Cattle in Jilin Province, China (Grant no. YDZJ202203CGZH043) and Scientific Research Project of Education Department of Jilin Province (Grant no. JJKH20230629KJ). This research also was supported by the Research Fund of Engineering Research Center of North-East Cold Region Beef Cattle Science and Technology Innovation, Ministry of Education and the "111" Project (D20034), China and Yanbian University Research Program (Grant no. ydxq202207).

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