과제정보
This study was supported by the Technology development Program (S3269035) funded by the Ministry of SMEs and Startups (MSS), Korea.
참고문헌
- Mann RE, Smart RG, Govoni R. 2003. The epidemiology of alcoholic liver disease. Alcohol Res. Health 27: 209-219.
- Zakhari S. 2006. Overview: how is alcohol metabolized by the body? Alcohol Res. Health 29: 245.
- O'shea RS, Dasarathy S, McCullough AJ. 2010. Alcoholic liver disease. Hepatology 51: 307-328.
- Handler JA, Thurman RG. 1990. Redox interactions between catalase and alcohol dehydrogenase pathways of ethanol metabolism in the perfused rat liver. J. Appl. Biol. Chem. 265: 1510-1515.
- Setshedi M, Wands JR, de la Monte SM. 2010. Acetaldehyde adducts in alcoholic liver disease. Oxid. Med. Cell. Longev. 3: 178-185.
- Rong S, Zhao Y, Bao W, Xiao X, Wang D, Nussler AK, et al. 2012. Curcumin prevents chronic alcohol-induced liver disease involving decreasing ROS generation and enhancing antioxidative capacity. Phytomedicine 19: 545-550.
- Cunningham CC, Bailey SM. 2001. Ethanol consumption and liver mitochondria function. Neurosignals 10: 271-282.
- Rasineni K, Casey CA. 2012. Molecular mechanism of alcoholic fatty liver. Indian J. Pharmacol. 44: 299-303.
- You M, Matsumoto M, Pacold CM, Cho W, Crabb DW. 2004. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 127: 1798-1808.
- Suraweera DB, Weeratunga AN, Hu RW, Pandol SJ, Hu R. 2015. Alcoholic hepatitis: the pivotal role of Kupffer cells. World J. Gastrointest. Pathophysiol. 6: 90-98.
- Ho JY, Hendi AS. 2018. Recent trends in life expectancy across high income countries: retrospective observational study. BMJ 362: k2562.
- da Silva Lucas AJ, de Oliveira LM, Da Rocha M. Prentice C. 2020. Edible insects: an alternative of nutritional, functional and bioactive compounds. Food Chem. 311: 126022.
- Mintah BK, He R, Agyekum AA, Dabbour M, Golly MK, Ma H. 2020. Edible insect protein for food applications: extraction, composition, and functional properties. J. Food Process Eng. 43: e13362.
- Yoon CH, Jeon SH, Ha YJ, Kim, SW, Bang WY, Bang KH, et al. 2020. Functional chemical components in Protaetia brevitarsis larvae: impact of supplementary feeds. Korean J. Food Sci. Anim. Resour. 40: 461.
- Ahn EM, Myung NY, Jung HA, Kim SJ. 2019. The ameliorative effect of Protaetia brevitarsis larvae in HFD-induced obese mice. Food Sci. Biotechnol. 28: 1177-1186.
- Ganguly K, Jeong MS, Dutta SD, Patel DK, Cho SJ, Lim KT. 2020. Protaetia brevitarsis seulensis derived protein isolate with enhanced osteomodulatory and antioxidative property. Molecules 25: 6056.
- Lee JE, Jo DE, Lee AJ, Park HK, Youn K, Yun EY, et al. 2014. Hepatoprotective and antineoplastic properties of Protaetia brevitarsis larvae. Entomol. Res. 44: 244-253.
- Kim TK, Yong HI, Kim YB, Jung S, Kim HW, Choi YS. 2021. Effects of organic solvent on functional properties of defatted proteins extracted from Protaetia brevitarsis larvae. Food Chem. 336: 127679.
- Dai C, Hou Y, Xu H, Huang L, Dabbour M, Mintah BK, et al. 2022. Effect of solid-state fermentation by three different Bacillus species on composition and protein structure of soybean meal. J. Sci. Food Agric. 102: 557-566.
- Mesgari-Abbasi M, Valizadeh H, Mirzakhani N, Vahdatpour T. 2022. Protective effects of di- and tri-peptides containing proline, glycine, and leucine on liver enzymology and histopathology of diabetic mice. Arch. Physiol. Biochem. 128: 59-68.
- Millward DJ. 2012. Amino acid scoring patterns for protein quality assessment. Br. J. Nutr. 108: S31-S43.
- Bostian KA, Betts GF. 1978. Rapid purification and properties of potassium-activated aldehyde dehydrogenase from Saccharomyces cerevisiae. Biochem. J. 173: 773786.
- Kwon BS, Kim JM, Park SK, Kang JY, Kang JE, Lee CJ, et al. 2019. Chronic alcohol exposure induced neuroapoptosis: diminishing effect of ethyl acetate fraction from Aralia elata. Oxid. Med. Cell. Longev. 2019: 7849876.
- Ghani MA, Barril C, Bedgood DR, Jr Prenzler PD. 2017. Measurement of antioxidant activity with the thiobarbituric acid reactive substances assay. Food Chem. 230: 195-207.
- Hissin PJ, Hilf RA. 1976. fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 74: 214-226.
- Park SK, Lee HL, Kang JY, Kim JM, Heo HJ. 2022. Peanut (Arachis hypogaea) sprout prevents high-fat diet-induced cognitive impairment by improving mitochondrial function. Sci. Rep. 12: 6213.
- Zor T, Selinger Z. 1996. Linearization of the Bradford protein assay increases its sensitivity: theoretical and experimental studies. Anal. Biochem. 236: 302-308.
- Ahmed E, Fukuma N, Hanada M, Nishida T. 2021. Insects as novel ruminant feed and a potential mitigation strategy for methane emissions. Animals 11: 2648.
- Van Huis A, Oonincx DG. 2017. The environmental sustainability of insects as food and feed. A review. Agron. Sustain. Dev. 37: 43.
- Jager R, Zaragoza J, Purpura M, Iametti S, Marengo M, Tinsley GM. et al. 2020. Probiotic administration increases amino acid absorption from plant protein: a placebo-controlled, randomized, double-blind, multicenter, crossover study. Probiotics Antimicrob. Proteins 12: 1330-1339.
- Dullius A, Fassina P, Giroldi M, Goettert MI, de Souza CFV. 2020. A biotechnological approach for the production of branched chain amino acid containing bioactive peptides to improve human health: a review. Food Res. J. 131: 109002.
- Nie C, He T, Zhang W, Zhang G, Ma X. 2018. Branched chain amino acids: beyond nutrition metabolism. Int. J. Mol. Sci. 19: 954.
- Park CE, Lee SO. 2023. Nrf2-mediated protective effect of protein hydrolysates from Protaetia brevitarsis larvae against oxidative stress-induced hepatotoxicity. Food Sci. Biotechnol. 32: 1561-1571.
- Ma Y, Meregalli M, Hodges S, Davies N, Bogdanos DP, Fargion, S, et al. 2005. Alcohol dehydrogenase: an autoantibody target in patients with alcoholic liver disease. Int. J. Immunopathol. Pharmacol. 18: 173-182.
- Lu Y, Cederbaum AI. 2018. Cytochrome P450s and alcoholic liver disease. Curr. Pharm. Des. 24: 1502-1517.
- Teschke R. 2018. Alcoholic liver disease: alcohol metabolism, cascade of molecular mechanisms, cellular targets, and clinical aspects. Biomedicines 6: 106.
- Lieber CS. 2020. Alcohol-induced hepatotoxicity, pp. 481-523. Robert GM, Steadman H (eds.), Hepatotoxicology, 1st Ed. Taylor & Francis Group, Oxfordshire, UK.
- Guo R, Ren J. 2010. Alcohol and acetaldehyde in public health: from marvel to menace. Int. J. Environ. Res. Public Health 7: 1285-1301.
- Tuma DJ. 2002. Role of malondialdehyde-acetaldehyde adducts in liver injury. Free Radic. Biol. Med. 32: 303-308.
- Peana AT, Assaretti AR, Muggironi G, Enrico P, Diana M. 2009. Reduction of ethanol-derived acetaldehyde induced motivational properties by L-cysteine. Alcohol Clin. Exp. Res. 33: 43-48.
- Bae SM, Lee SC. 2020. Effect of subcritical water extraction conditions on the activity of alcohol metabolizing enzymes, ACE inhibition, and tyrosinase inhibition in Protaetia brevitarsis larvae. Food Sci. Biotechnol. 29: 867-872.
- Murakami H, Ito M, Furukawa Y, Komai M. 2012. Leucine accelerates blood ethanol oxidation by enhancing the activity of ethanol metabolic enzymes in the livers of SHRSP rats. Amino Acids 43: 2545-2551.
- Ali LH, Rajab WJ. 2019. The effect of Lepidium Sativum seeds extract on some oxidative stress, antioxidants and histological changes in rat treated with CCl4. Pak. J. Biotechnol. 16: 145-151.
- Ighodaro OM, Akinloye OA. 2018. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid. Alexandria J. Med. 54: 287-293.
- Lee HC, Hwang SG, Kang YK, Sohn YO, Moon JY, Lim HB et al. 2001. Influence of Protaetia brevitarsis extract on liver damage induced by carbon tetrachloride and ethanol in rats. Korean J. Life Sci. 11: 405-414.
- Smirnoff N, Cumbes QJ. 1989. Hydroxyl radical scavenging activity of compatible solutes. Phytochemistry 28: 1057-1060.
- Matysik J, Alia Bhalu B, Mohanty P. 2002. Molecular mechanisms of quenching of reactive oxygen species by proline under stress in plants. Curr. Sci. 82: 525-532.
- Lee JH, Kim TK, Kang MC, Kim BK, Choi YS. 2023. Protective effects of edible insect protein extracts from Protaetia brevitarsis against H2O2-induced oxidative stress in mouse C2C12 myoblast cells. Food Biosci. 52: 102396.
- Tedesco L, Corsetti G, Ruocco C, Ragni M, Rossi F, Carruba MO. et al. 2018. Specific amino acid formula prevents alcoholic liver disease in rodents. Am. J. Physiol. Gastrointest. Liver Physiol. 314: G566-G582.
- Newsholme P, Rebelato E, Abdulkader F, Krause M, Carpinelli A, Curi, R. 2021. Reactive oxygen and nitrogen species generation, antioxidant defenses, and β-cell function: a critical role for amino acids. J. Endocrinol. 214: 11-20.
- Xiao J, Zhang R, Huang F, Liu L, Deng Y, Ma Y, et al. 2017. Lychee (Litchi chinensis Sonn.) pulp phenolic extract confers a protective activity against alcoholic liver disease in mice by alleviating mitochondrial dysfunction. J. Agric. Food Chem. 65: 5000-5009.
- Domschke S, Domschke W, Lieber CS. 1974. Hepatic redox state: attentuation of the acute effects of ethanol induced by chronic ethanol consumption. Life Sci. 15: 1327-1334.
- Zorova LD, Popkov VA, Plotnikov EY, Silachev DN, Pevzner IB. et al. 2018. Mitochondrial membrane potential. Anal. Biochem. 552: 50-59.
- Sun Q, Zhong W, Zhang W, Zhou Z. 2016. Defect of mitochondrial respiratory chain is a mechanism of ROS overproduction in a rat model of alcoholic liver disease: role of zinc deficiency. Am. J. Physiol. Gastrointest. Liver Physiol. 310: G205-G214.
- Zhang H, Liu X, Fan Y, Yu Y, Loor JJ, Elsabagh M, et al. 2021. L-Arginine alleviates hydrogen peroxide-induced oxidative damage in ovine intestinal epithelial cells by regulating apoptosis, mitochondrial function, and autophagy. J. Nutr. 151: 1038-1046.
- Xia Y, Li Q, Zhong W, Dong J, Wang Z, Wang C. 2011. L-carnitine ameliorated fatty liver in high-calorie diet/STZ-induced type 2 diabetic mice by improving mitochondrial function. Diabetol. Metab. Syndr. 3: 31.
- Malaguarnera M, Bella R, Vacante M, Giordano M, Malaguarnera G, Gargante MP. 2011. Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy. Scand. J. Gastroenterol. 46: 750-759.
- Dadsena S, King LE, Garcia-Saez AJ. 2021. Apoptosis regulation at the mitochondria membrane level. Biochim. Biophys. Acta 1863: 183716.
- Mansouri A, Gattolliat CH, Asselah T. 2018. Mitochondrial dysfunction and signaling in chronic liver diseases. Gastroenterology 155: 629-647.
- Wang C, Youle RJ. 2009. The role of mitochondria in apoptosis. Annu. Rev. Genet. 43: 95-118.
- Tu PS, Tung YT, Lee WT, Yen GC. 2017. Protective effect of camellia oil (Camellia oleifera Abel.) against ethanol-induced acute oxidative injury of the gastric mucosa in mice. J. Agric. Food Chem. 65: 4932-4941.
- Wang Q, Liu S, Zhai A, Zhang B, Tian, G. 2018. AMPK-mediated regulation of lipid metabolism by phosphorylation. Biol. Pharm. Bull. 41: 985-993.
- You M, Matsumoto M, Pacold CM, Cho WK, Crabb DW. 2004. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 127: 1798-1808.
- Bai T, Yang Y, Yao YL, Sun P, Lian LH, Wu YL, et al. 2016. Betulin alleviated ethanol-induced alcoholic liver injury via SIRT1/AMPK signaling pathway. Pharmacol. Res. 105: 1-12.
- Wada S, Yamazaki T, Kawano Y, Miura S, Ezaki O. 2008. Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice. J. Hepatol. 49: 441-450.
- You M, Fischer M, Deeg MA, Crabb DW. 2002. Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J. Biol. Chem. 277: 29342-29347.
- Lee EH, Chun SY, Yoon B, Han MH, Chung JW, Ha YS, et al. 2022. Anti-obesity and hepatoprotective effects of protein hydrolysates derived from Protaetia brevitarsis in an obese mouse model. BioMed Res. Int. 2022: 4492132.
- Hong KS, Yun SM, Cho JM, Lee DY, Ji SD, Son JG, et al. 2018. Silkworm (Bombyx mori) powder supplementation alleviates alcoholic fatty liver disease in rats. J. Funct. Foods 43: 29-36.
- Lieber CS. 2004. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol 34: 9-19.
- Szabo G. 2015. Gut-liver axis in alcoholic liver disease. Gastroenterology 148: 30-36.
- Tsutsui H, Nishiguchi S. 2014. Importance of Kupffer cells in the development of acute liver injuries in mice. Int. J. Mol. Sci. 15: 7711-7730.
- Mandrekar P, Szabo G. 2009. Signaling pathways in alcohol-induced liver inflammation. J. Hepatol. 50: 1258-1266.
- Choi YJ, Bae IY. 2023. White-spotted flower chafer (Protaetia brevitarsis) ameliorates inflammatory responses in LPS-stimulated RAW 264.7 macrophages. J. Insects Food Feed 9: 1037-1046.
- Myung NY, Ahn EM, Kim SJ. 2020. The anti-inflammatory mechanism of Protaetia brevitarsis lewis via suppression the activation of NF-κB and caspase-1 in LPS-stimulated RAW 264. 7 cells. Biomed. Sci. Lett. 26: 267-274.
- Nanji AA, Jokelainen K, Lau GK, Rahemtulla A, Tipoe GL, Polavarapu R, et al. 2001. Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration. J. Pharmacol. Exp. Ther. 299: 832-839.
- Juarez-Hernandez E, Chavez-Tapia NC, Uribe M, Barbero-Becerra VJ. 2015. Role of bioactive fatty acids in nonalcoholic fatty liver disease. Nutr. J. 15: 72.
- Warner DR, Liu H, Miller ME, Ramsden CE, Gao B, Feldstein AE, et al. 2017. Dietary linoleic acid and its oxidized metabolites exacerbate liver injury caused by ethanol via induction of hepatic proinflammatory response in mice. Am. J. Clin. Pathol. 187: 2232-2245.
- Ducheix S, Montagner A, Polizzi A, Lasserre F, Regnier M, Marmugi A, et al. 2017. Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling. PLoS One 12: e0181393.
- Ramos-Tovar E, Muriel P. 2020. Molecular mechanisms that link oxidative stress, inflammation, and fibrosis in the liver. Antioxidants 9: 1279.
- Moreira RK. 2007. Hepatic stellate cells and liver fibrosis. Arch. Pathol. Lab. Med. 131: 1728-1734.
- Okamoto K, Mimura K, Murawaki Y, Yuasa, I. 2005. Association of functional gene polymorphisms of matrix metalloproteinase (MMP)-1, MMP-3 and MMP-9 with the progression of chronic liver disease. J. Gastroenterol. Hepatol. 20: 1102-1108.
- Peng J, Li X, Feng Q, Chen L, Xu L, Hu, Y. 2013. Anti-fibrotic effect of Cordyceps sinensis polysaccharide: inhibiting HSC activation, TGF-β1/Smad signaling, MMPs and TIMPs. Exp. Biol. Med. 238: 668-677.
- Khedr NF, Khedr EG. 2017. Branched chain amino acids supplementation modulates TGF-β1/Smad signaling pathway and interleukins in CCl4-induced liver fibrosis. Fundam. Clin. Pharmacol. 31: 534-545.
- Matsui H, Ikeda K, Nakajima Y, Horikawa S, Imanishi Y, Kawada N. 2004. Sulfur-containing amino acids attenuate the development of liver fibrosis in rats through down-regulation of stellate cell activation. J. Hepatol. 40: 917-925.