Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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In vivo Effects of Salicornia herbacea and Calystegia soldanella Extracts for Memory Improvement

  • Jiun Sang (Department of Bio and Fermentation Convergence Technology, Kookmin University) ;
  • Seeta Poudel (Department of Bio and Fermentation Convergence Technology, Kookmin University) ;
  • Youngseok Lee (Department of Bio and Fermentation Convergence Technology, Kookmin University)
  • Received : 2023.12.29
  • Accepted : 2024.02.26
  • Published : 2024.05.28
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Abstract

The global elderly population, aged 65 and over, reached approximately 10% in 2020, and this proportion is expected to continue rising. Therefore, the prevalence of neurodegenerative diseases such as Parkinson's disease (PD), which are characterized by declining memory capabilities, is anticipated to increase. In a previous study, we successfully restored the diminished memory capabilities in a fruit fly model of PD by administering an omija extract. To identify functional ingredients that can enhance memory akin to the effects of the omija extract, we conducted screenings by administering halophyte extracts to the PD model. Halophytes are plants that thrive in high-salt environments, and given Korea's geographic proximity to the sea on three sides, it serves as an optimal hub for the utilization of these plants. Upon examining the effects of the oral administration of 12 halophyte extracts, Salicornia herbacea and Calystegia soldanella emerged as potential candidates for ameliorating memory loss in PD model flies. Moreover, our findings suggested that C. soldanella, but not S. herbacea, can mitigate oxidative stress in DJ-1β mutants.

Keywords

Acknowledgement

This work was supported by grants to Y.L. from the National Research Foundation of Korea (NRF) funded by the Korea government (MIST) (NRF-2021R1A2C1007628) and the Biomaterials Specialized Graduate Program through the Korea Environmental Industry and Technology Institute (KEITI) funded by the Ministry of Environment (MOE).

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