과제정보
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2021R1A2C2007712).
참고문헌
- Han J. 2019. Chemical aspects of gut metabolism of flavonoids. Metabolites 9: 136.
- Mi HTN, Chaiyasarn S, Eser BE, Tan SRS, Burapan S, Han J. 2022. Allyl aryl ether cleavage by Blautia sp. MRG-PMF1 Co corrinoid O-demethylase. Microbiol. Spectr. 10: e0330522.
- Kim M, Marsh ENG, Kim SU, Han J. 2010. Conversion of (3S,4R)-tetrahydrodaidzein to (3S)-equol by THD reductase: proposed mechanism involving a radical intermediate. Biochemistry 49: 5582-5587.
- Akao T, Che Q, Kobashi K, Hattori M, Namba T. 1996. A purgative action of barbaloin is induced by Eubacterium sp. strain BAR, a human intestinal anaerobe, capable of transforming barbaloin to aloe-emodinanthrone. Biol. Pharm. Bull. 19: 136-138.
- Wei B, Wang YK, Qiu WH, Wang SJ, Wu YH, Xu XW, et al. 2020. Discovery and mechanism of intestinal bacteria in enzymatic cleavage of C-C glycosidic bonds. Appl. Microbiol. Biotechnol. 104: 1883-1890.
- Nakamura K, Zhu S, Komatsu K, Hattori M, Iwashima M. 2020. Deglycosylation of the isoflavone C-glucoside puerarin by a combination of two recombinant bacterial enzymes and 3-oxo-glucose. Appl. Environ. Microbiol. 86: e00607-20.
- Mori T, Kumano T, He H, Watanabe S, Senda M, Moriya T, et al. 2021. C-Glycoside metabolism in the gut and in nature: identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes. Nat. Commun. 12: 6294.
- Choi J, Kim Y, Eser BE, Han J. 2023. Theoretical study on the glycosidic C-C bond cleavage of 3''-oxo-puerarin. Sci. Rep. 13: 16282.
- Burapan S, Kim M, Han J. 2017. Curcuminoid demethylation as an alternative metabolism by human intestinal microbiota. J. Agric. Food Chem. 65: 3305-3310.
- Kim M, Kim N, Han J. 2014. Metabolism of Kaempferia parviflora polymethoxyflavones by human intestinal bacterium Bautia sp. MRG-PMF1. J. Agric. Food Chem. 62: 12377-12383.
- Kim M, Lee J, Han J. 2015. Deglycosylation of isoflavone C-glycosides by newly isolated human intestinal bacteria. J. Sci. Food Agric. 95: 1925-1931.
- Mi HTN, Chaiyasarn S, Kim H, Han J. 2023. C-Glycoside-metabolizing human gut bacterium, Dorea sp. MRG-IFC3. J. Microbiol. Biotechnol. 33: 1606-1614.
- Kumano T, Hori S, Watanabe S, Kobayashi M. 2021. FAD-dependent C-glycoside-metabolizing enzymes in microorganisms: screening, characterization, and crystal structure analysis. Proc. Natl. Acad. Sci. USA 118: e2106580118.
- Braune A, Engst W, Blaut M. 2016. Identification and functional expression of genes encoding flavonoid O- and C-glycosidases in intestinal bacteria. Environ. Microbiol. 18: 2117-2129.
- Bag S, Mondal A, Majumder A, Mondal SK, Banik A. 2022. Flavonoid mediated selective cross-talk between plants and beneficial soil microbiome. Phytochem. Rev. 21: 1739-1760.
- Bitter J, Pfeiffer M, Borg AJE, Kuhlmann K, Pavkov-Keller T, Snchez-Murcia PA, et al. 2023. Enzymatic β-elimination in natural product O- and C-glycoside deglycosylation. Nat. Commun. 14: 7123.