한방비만학회지 (Journal of Korean Medicine for Obesity Research)

  • 제24권1호
  • /
  • Pages.68-75
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  • 2024
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  • 1976-9334(pISSN)
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  • 2288-1522(eISSN)
한방비만학회 (The Society of Korean Medicine for obesity Research)
권호 표지
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가미태음조위탕 2주 복용이 과체중 또는 비만 환자의 혈압, 맥박수 및 체중에 미치는 영향: 후향적 차트리뷰

The Effect of Taking Gamitaeeumjowee-tang for 2 Weeks on Blood Pressure, Pulse Rate and Body Weight in Overweight or Obese Patients: A Retrospective Chart Review

  • 박소영 (누베베비만연구소) ;
  • 박민정 (누베베비만연구소) ;
  • 김은주 (누베베비만연구소) ;
  • 김은서 (고도한의원) ;
  • 임영우 (누베베비만연구소)
  • Soyoung Park (Nubebe Obesity Research Institute) ;
  • Min-jeong Park (Nubebe Obesity Research Institute) ;
  • Eunjoo Kim (Nubebe Obesity Research Institute) ;
  • Eunseo Kim (GODO Korean Medicine Clinic) ;
  • Young-Woo Lim (Nubebe Obesity Research Institute)
  • 투고 : 2024.05.03
  • 심사 : 2024.05.29
  • 발행 : 2024.06.30
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초록

Objectives: This study was aimed to evaluate changes in blood pressure, pulse rate and body weight of overweight or obese patients after two weeks of taking Gamitaeeumjowee-tang. Methods: A retrospective chart review was conducted for patients with auscultatory blood pressure records who visited the clinic after two weeks from the first visit between July 8, 2019 and August 30, 2019. Results: A total of seventy-two patients were included. There were significant differences in systolic blood pressure (121.69±14.3 mmHg to 117.37±12.3 mmHg, P=0.002) and pulse rate (78.56±9.3 bpm to 82.99±9.0 bpm, P<0.001). There was no significant difference in diastolic blood pressure. There were significant differences in body weight (76.28±13.5 kg to 73.41±13.1 kg, P<0.001) and body mass index (28.82±4.4 kg/m2 to 27.75±4.3 kg/m2, P<0.001). Conclusions: In this study, blood pressure tended to decrease and pulse rate slightly increased after two weeks of taking Gamitaeeumjowee-tang. It is necessary to notice the possibility of pulse rate increase and the plan of action when using Gamitaeeumjowee-tang. Additional well-designed investigations are needed.

키워드

참고문헌

  1. Bray GA, Bouchard C. Handbook of obesity: epidemiology, etiology, and physiopathology. 3rd ed. CRC Press. 2014 : 8-12. 
  2. Yang YS, Han BD, Han K, Jung JH, Son JW; Taskforce Team of the Obesity Fact Sheet of the Korean Society for the Study of Obesity. Obesity fact sheet in Korea, 2021: trends in obesity prevalence and obesity-related comorbidity incidence stratified by age from 2009 to 2019. J Obes Metab Syndr. 2022 ; 31(2) : 169-77. 
  3. Kim KK, Haam JH, Kim BT, Kim EM, Park JH, Rh ee SY, et al. Evaluation and treatment of obesity and its comorbidities: 2022 update of clinical practice guidelines for obesity by the Korean society for the study of obesity. J Obes Metab Syndr. 2023 ; 32(1) : 1-24. 
  4. Jegal KH, Ko MM, Kim BY, Son MJ, Kim S. A national survey on current clinical practice pattern of Korean medicine doctors for treating obesity. PLoS One. 2022 ; 17(3) : e0266034. 
  5. Stohs SJ, Shara M, Ray SD. p-Synephrine, ephedrine, p-octopamine and m-synephrine: comparative mechanistic, physiological and pharmacological properties. Phytother Res. 2020 ; 34(8) : 1838-46. 
  6. Haller CA, Jacob P, Benowitz NL. Short-term metabolic and hemodynamic effects of ephedra and guarana combinations. Clin Pharmacol Ther. 2005 ; 77(6) : 560-71. 
  7. White LM, Gardner SF, Gurley BJ, Marx MA, Wang PL, Estes M. Pharmacokinetics and cardiovascular effects of ma-huang (Ephedra sinica) in normotensive adults. J Clin Pharmacol. 1997 ; 37(2) : 116-22. 
  8. Hsing LC, Lee TH, Son DH, Yeo JJ, Yang CS, Seo ES, et al. Adverse effects of Ma-huang according to dose: a randomized double-blind placebo-controlled pilot study. J Int Korean Med. 2006 ; 27(1) : 188-96. 
  9. Lee AR, Lee DY, Kim MJ, Lee HS, Choi KH, Kim SY, et al. Gamitaeeumjowee-tang for weight loss in diabetic patients: a retrospective chart review. J Korean Med. 2021 ; 42(1) : 46-58. 
  10. Kim MJ, Won BY, Kim HJ, Choi KH. Clinical application of Gamitaeeumjowee-tang for overweight or obese hypothyroidism patients: a retrospective chart review. J Korean Med Obes Res. 2023 ; 23(2) : 78-85. 
  11. Park MJ, Kim E, Ok JM, Ch oi KH, Lim YW. Gamitaeeumjowee-tang for weight loss in overweight and obese women with polycystic ovary syndrome: a retrospective chart review. J Korean Med Obes Res. 2022 ; 22(2) : 136-46. 
  12. Park J, Bose S, Hong SW, Lee DK, Yoo JW, Lim CY, et al. Impact of GNB3-C825T, ADRB3-Trp64Arg, UCP2-3'UTR 45 bp del/ins, and PPARγ-Pro12Ala polymorphisms on Bofutsushosan response in obese subjects: a randomized, double-blind, placebo-controlled trial. J Med Food. 2014 ; 17(5) : 558-70. 
  13. Park S, Nahmkoong W, Cheon C, Park JS, Jang BH, Shin Y, et al. Efficacy and safety of Taeeumjowi-tang in obese Korean adults: a double-blind, randomized, and placebo-controlled pilot trial. Evid Based Complement Alternat Med. 2013 ; 2013 : 498935. 
  14. Shekelle P, Hardy ML, Morton SC, Maglione M, Suttorp M, Roth E, et al. Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects. Evid Rep Technol Assess (Summ). 2003 ; (76) : 1-4. 
  15. Yoon NR, Yoo YJ, Kim MJ, Kim SY, Lim YW, Lim HH, et al. Analysis of adverse events in weight loss program in combination with 'Gamitaeeumjowee-tang' and low-calorie diet. J Korean Med Obes Res. 2018 ; 18(1) : 1-9. 
  16. Xue X, Lv X, Ma X, Zhou Y, Yu N, Yang Z. Prevention of spinal hypotension during cesarean section: a systematic review and Bayesian network meta-analysis based on ephedrine, phenylephrine, and norepinephrine. J Obstet Gynaecol Res. 2023 ; 49(7) : 1651-62. 
  17. Song MY, Kim HJ, Lee MJ. The safety guidelines for use of Ma-huang in obesity treatment. J Korean Med Obes Res. 2006 ; 6(2) : 17-27. 
  18. Kalman D, Incledon T, Gaunaurd I, Schwartz H, Krieger D. An acute clinical trial evaluating the cardiovascular effects of an herbal ephedra-caffeine weight loss product in healthy overweight adults. Int J Obes Relat Metab Disord. 2002 ; 26(10) : 1363-6. 
  19. Coffey CS, Steiner D, Baker BA, Allison DB. A randomized double-blind placebo-controlled clinical trial of a product containing ephedrine, caffeine, and other ingredients from herbal sources for treatment of overweight and obesity in the absence of lifestyle treatment. Int J Obes Relat Metab Disord. 2004 ; 28(11) : 1411-9. 
  20. Greenway FL, De Jonge L, Blanchard D, Frisard M, Smith SR. Effect of a dietary herbal supplement containing caffeine and ephedra on weight, metabolic rate, and body composition. Obes Res. 2004 ; 12(7) : 1152-7. 
  21. Hackman RM, Havel PJ, Schwartz HJ, Rutledge JC, Watnik MR, Noceti EM, et al. Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trial. Int J Obes (Lond). 2006 ; 30(10) : 1545-56. 
  22. Jo GW, Ok JM, Kim SY, Lim YW. Review on the efficacy and safety of Mahuang and ephedrine in the treatment of obesity-focused on RCT. J Korean Med. 2017 ; 38(3) : 170-84. 
  23. Yoo HJ, Yoon HY, Yee J, Gwak HS. Effects of ephedrine-containing products on weight loss and lipid profiles: a systematic review and meta-analysis of randomized controlled trials. Pharmaceuticals (Basel). 2021 ; 14(11) : 1198. 
  24. Olsson K, Salier Eriksson J, Rosdahl H, Schantz P. Are heart rate methods based on ergometer cycling and level treadmill walking interchangeable? PLoS One. 2020 ; 15(8) : e0237388. 
  25. Farinatti PT, Brandao C, Soares PP, Duarte AF. Acute effects of stretching exercise on the heart rate variability in subjects with low flexibility levels. J Strength Cond Res. 2011 ; 25(6) : 1579-85. 
  26. Noh EJ, Ch oi SJ, Kim DH, Ch oi YS, Kim DI. A preliminary study on the change of intraday heart rate variability and related factors in healthy people. J Korean Med. 2021 ; 42(2) : 50-61. 
  27. Choi CJ, Choi WS, Kim KS. The changes in heart rate variability between morning and afternoon. J Korean Acad Fam Med. 2008 ; 29(8) : 579-84. 
  28. Association of Korean Medicine Professors for Cardiovascular and Neurological Medicine. Cardiovascular and neurological medicine in Korean medicine. Seoul : Woori Medical Books. 2016 : 38-43. 
  29. Kawamura M, Adachi T, Nakajima J, Fujiwara T, Hiramori K. Factors that affect calorie-sensitive and calorie-insensitive reduction in blood pressure during short-term calorie restriction in overweight hypertensive women. Hypertension. 1996 ; 27(3 Pt 1) : 408-13.