한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제41권3호
  • /
  • Pages.143-149
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  • 2024
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
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Investigation of Circulating Cell-Free DNA Concentration in Dogs with Pancreatitis

  • Jae-Hun Kim (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Jeonbuk National University) ;
  • Soo-Yeon Jeong (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Jeonbuk National University) ;
  • Chul Park (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Jeonbuk National University)
  • 투고 : 2024.02.29
  • 심사 : 2024.05.16
  • 발행 : 2024.06.30
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초록

Circulating cell-free DNA (cfDNA) constitutes a fragment of DNA released into the blood through cellular apoptosis or necrosis. In human medicine, cfDNA has been studied as a disease severity biomarker. Recent studies have shown that concentrations of cfDNA in dogs with immune-mediated and tumor-related diseases are increased. Pancreatitis is known to be caused by excessive release of trypsin, which leads to edema, inflammation, necrosis, and apoptosis in the pancreas. Based on the results of research showing an increase of cfDNA due to apoptosis and necrosis of cells, we hypothesized that cfDNA concentration would increase in the presence of pancreatitis. A total of 35 dogs were studied, including 21 with pancreatitis and 14 without any inflammatory diseases (normal group). The results showed that the concentration of cfDNA in dogs with pancreatitis was approximately twice that of normal dogs (median 0.0912 ng/μL. p-value 0.028). This result suggests that cfDNA can serve as a new biomarker for estimating pancreatitis severity.

키워드

과제정보

This work was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through a Companion Animal Life Cycle Industry Technology Development Program funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (322094-03).

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